SKP1_CHICK
ID SKP1_CHICK Reviewed; 163 AA.
AC Q5ZKF5;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=S-phase kinase-associated protein 1;
DE AltName: Full=Cyclin-A/CDK2-associated protein p19;
DE AltName: Full=S-phase kinase-associated protein 1A;
DE AltName: Full=p19A;
DE AltName: Full=p19skp1;
GN Name=SKP1; Synonyms=SKP1A; ORFNames=RCJMB04_11c19;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=CB; TISSUE=Bursa of Fabricius;
RX PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA Hayashizaki Y., Buerstedde J.-M.;
RT "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT function analysis.";
RL Genome Biol. 6:R6.1-R6.9(2005).
CC -!- FUNCTION: Essential component of the SCF (SKP1-CUL1-F-box protein)
CC ubiquitin ligase complex, which mediates the ubiquitination of proteins
CC involved in cell cycle progression, signal transduction and
CC transcription. In the SCF complex, serves as an adapter that links the
CC F-box protein to CUL1 (By similarity). {ECO:0000250}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- SIMILARITY: Belongs to the SKP1 family. {ECO:0000305}.
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DR EMBL; AJ720129; CAG31788.1; -; mRNA.
DR RefSeq; NP_001006153.1; NM_001006153.1.
DR AlphaFoldDB; Q5ZKF5; -.
DR SMR; Q5ZKF5; -.
DR BioGRID; 677840; 1.
DR STRING; 9031.ENSGALP00000010447; -.
DR PaxDb; Q5ZKF5; -.
DR Ensembl; ENSGALT00000010461; ENSGALP00000010447; ENSGALG00000006474.
DR Ensembl; ENSGALT00000072062; ENSGALP00000048383; ENSGALG00000006474.
DR Ensembl; ENSGALT00000103985; ENSGALP00000072345; ENSGALG00000006474.
DR GeneID; 416319; -.
DR KEGG; gga:416319; -.
DR CTD; 6500; -.
DR VEuPathDB; HostDB:geneid_416319; -.
DR eggNOG; KOG1724; Eukaryota.
DR GeneTree; ENSGT00390000012652; -.
DR HOGENOM; CLU_059252_7_0_1; -.
DR InParanoid; Q5ZKF5; -.
DR OMA; PLKSADM; -.
DR OrthoDB; 1412723at2759; -.
DR PhylomeDB; Q5ZKF5; -.
DR TreeFam; TF354233; -.
DR Reactome; R-GGA-1169091; Activation of NF-kappaB in B cells.
DR Reactome; R-GGA-174113; SCF-beta-TrCP mediated degradation of Emi1.
DR Reactome; R-GGA-187577; SCF(Skp2)-mediated degradation of p27/p21.
DR Reactome; R-GGA-195253; Degradation of beta-catenin by the destruction complex.
DR Reactome; R-GGA-2565942; Regulation of PLK1 Activity at G2/M Transition.
DR Reactome; R-GGA-5684264; MAP3K8 (TPL2)-dependent MAPK1/3 activation.
DR Reactome; R-GGA-68949; Orc1 removal from chromatin.
DR Reactome; R-GGA-69231; Cyclin D associated events in G1.
DR Reactome; R-GGA-8854050; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
DR Reactome; R-GGA-8939902; Regulation of RUNX2 expression and activity.
DR Reactome; R-GGA-8951664; Neddylation.
DR Reactome; R-GGA-917937; Iron uptake and transport.
DR Reactome; R-GGA-9708530; Regulation of BACH1 activity.
DR Reactome; R-GGA-9762114; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2.
DR Reactome; R-GGA-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR UniPathway; UPA00143; -.
DR PRO; PR:Q5ZKF5; -.
DR Proteomes; UP000000539; Chromosome 13.
DR Bgee; ENSGALG00000006474; Expressed in spermatid and 13 other tissues.
DR GO; GO:0031467; C:Cul7-RING ubiquitin ligase complex; ISS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0019005; C:SCF ubiquitin ligase complex; ISS:UniProtKB.
DR GO; GO:0097602; F:cullin family protein binding; IBA:GO_Central.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR GO; GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR016897; SKP1.
DR InterPro; IPR001232; SKP1-like.
DR InterPro; IPR036296; SKP1-like_dim_sf.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR016072; Skp1_comp_dimer.
DR InterPro; IPR016073; Skp1_comp_POZ.
DR PANTHER; PTHR11165; PTHR11165; 1.
DR Pfam; PF01466; Skp1; 1.
DR Pfam; PF03931; Skp1_POZ; 1.
DR PIRSF; PIRSF028729; E3_ubiquit_lig_SCF_Skp; 1.
DR SMART; SM00512; Skp1; 1.
DR SUPFAM; SSF54695; SSF54695; 1.
DR SUPFAM; SSF81382; SSF81382; 1.
PE 2: Evidence at transcript level;
KW Reference proteome; Ubl conjugation pathway.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250"
FT CHAIN 2..163
FT /note="S-phase kinase-associated protein 1"
FT /id="PRO_0000288493"
FT REGION 63..83
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 104..163
FT /note="Interaction with the F-box domain of F-box proteins"
FT /evidence="ECO:0000250"
SQ SEQUENCE 163 AA; 18658 MW; C794D62AFB75528A CRC64;
MPSIKLQSSD GEIFEVDVEI AKQSVTIKTM LEDLGMDDEG DDDPVPLPNV NAAILKKVIQ
WCTHHKDDPP PPEDDENKEK RTDDIPVWDQ EFLKVDQGTL FELILAANYL DIKGLLDVTC
KTVANMIKGK TPEEIRKTFN IKNDFTEEEE AQVRKENQWC EEK
