SKP1_TALSN
ID SKP1_TALSN Reviewed; 160 AA.
AC B8MDP8;
DT 10-AUG-2010, integrated into UniProtKB/Swiss-Prot.
DT 03-MAR-2009, sequence version 1.
DT 25-MAY-2022, entry version 56.
DE RecName: Full=E3 ubiquitin ligase complex SCF subunit sconC;
DE AltName: Full=Sulfur controller C;
DE AltName: Full=Sulfur metabolite repression control protein C;
GN Name=sconC; Synonyms=skpA; ORFNames=TSTA_120270;
OS Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL
OS 1006) (Penicillium stipitatum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Trichocomaceae; Talaromyces;
OC Talaromyces sect. Talaromyces.
OX NCBI_TaxID=441959;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006;
RX PubMed=25676766; DOI=10.1128/genomea.01559-14;
RA Nierman W.C., Fedorova-Abrams N.D., Andrianopoulos A.;
RT "Genome sequence of the AIDS-associated pathogen Penicillium marneffei
RT (ATCC18224) and its near taxonomic relative Talaromyces stipitatus
RT (ATCC10500).";
RL Genome Announc. 3:E0155914-E0155914(2015).
CC -!- FUNCTION: Essential component of the SCF (SKP1-CUL1-F-box protein) E3
CC ubiquitin ligase complexes, which mediate the ubiquitination and
CC subsequent proteasomal degradation of target proteins. Controls sulfur
CC metabolite repression, probably by mediating the inactivation or
CC degradation of the metR transcription factor (By similarity).
CC {ECO:0000250}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- SUBUNIT: Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin
CC ligase complexes. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SKP1 family. {ECO:0000305}.
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DR EMBL; EQ962655; EED18277.1; -; Genomic_DNA.
DR EMBL; EQ962655; EED18278.1; -; Genomic_DNA.
DR RefSeq; XP_002482269.1; XM_002482224.1.
DR RefSeq; XP_002482270.1; XM_002482225.1.
DR AlphaFoldDB; B8MDP8; -.
DR SMR; B8MDP8; -.
DR STRING; 441959.B8MDP8; -.
DR EnsemblFungi; EED18277; EED18277; TSTA_120270.
DR EnsemblFungi; EED18278; EED18278; TSTA_120270.
DR GeneID; 8100011; -.
DR VEuPathDB; FungiDB:TSTA_120270; -.
DR eggNOG; KOG1724; Eukaryota.
DR HOGENOM; CLU_059252_4_0_1; -.
DR InParanoid; B8MDP8; -.
DR OMA; PLKSADM; -.
DR OrthoDB; 1412723at2759; -.
DR PhylomeDB; B8MDP8; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000001745; Unassembled WGS sequence.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR016897; SKP1.
DR InterPro; IPR001232; SKP1-like.
DR InterPro; IPR036296; SKP1-like_dim_sf.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR016072; Skp1_comp_dimer.
DR InterPro; IPR016073; Skp1_comp_POZ.
DR PANTHER; PTHR11165; PTHR11165; 1.
DR Pfam; PF01466; Skp1; 1.
DR Pfam; PF03931; Skp1_POZ; 1.
DR PIRSF; PIRSF028729; E3_ubiquit_lig_SCF_Skp; 1.
DR SMART; SM00512; Skp1; 1.
DR SUPFAM; SSF54695; SSF54695; 1.
DR SUPFAM; SSF81382; SSF81382; 1.
PE 3: Inferred from homology;
KW Reference proteome; Ubl conjugation pathway.
FT CHAIN 1..160
FT /note="E3 ubiquitin ligase complex SCF subunit sconC"
FT /id="PRO_0000397271"
FT REGION 101..160
FT /note="Interaction with the F-box domain of F-box proteins"
FT /evidence="ECO:0000250"
SQ SEQUENCE 160 AA; 18577 MW; 2CD078E72FF64B6C CRC64;
MSGQVTLQSS DQVNITVERA VAERSMLIKN LLEDLGESEE PVPIPNVNES VLKKVIEWCT
HHKNDPQTTG EEDDNRRRTT EIDEWDQKFM QVDQEMLFEI ILAANYLDIK ALLDVGCKTV
ANMIKGKSPE EIRKTFNIQN DFTPEEEDQI RRENEWAEDR
