ID   SKP1_TETTS              Reviewed;         166 AA.
AC   A0PGB3; Q23AC7;
DT   17-JUN-2020, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2007, sequence version 1.
DT   25-MAY-2022, entry version 52.
DE   RecName: Full=S-phase kinase-associated protein 1 homolog {ECO:0000305};
DE   AltName: Full=Telomerase-associated protein of 20 kDa {ECO:0000303|PubMed:17220281};
DE            Short=p20 {ECO:0000303|PubMed:17220281};
GN   Name=SKP1 {ECO:0000303|PubMed:17220281};
GN   Synonyms=TAP20 {ECO:0000303|PubMed:17220281};
GN   ORFNames=TTHERM_00426320 {ECO:0000312|EMBL:EAR93565.2};
OS   Tetrahymena thermophila (strain SB210).
OC   Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC   Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC   Tetrahymena.
OX   NCBI_TaxID=312017;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=17220281; DOI=10.1128/mcb.02105-06;
RA   Witkin K.L., Prathapam R., Collins K.;
RT   "Positive and negative regulation of Tetrahymena telomerase holoenzyme.";
RL   Mol. Cell. Biol. 27:2074-2083(2007).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SB210;
RX   PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA   Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA   Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA   Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA   Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA   Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA   Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA   Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA   Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA   Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA   Hamilton E.P., Orias E.;
RT   "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT   model eukaryote.";
RL   PLoS Biol. 4:1620-1642(2006).
CC   -!- FUNCTION: Essential component of the SCF (SKP1-CUL1-F-box protein)
CC       ubiquitin ligase complex, which mediates the ubiquitination of proteins
CC       involved in cell cycle progression, signal transduction and
CC       transcription (By similarity). In the SCF complex, serves as an adapter
CC       that links the F-box protein to CUL1 (By similarity). The functional
CC       specificity of the SCF complex depends on the F-box protein as
CC       substrate recognition component (By similarity). Its association with
CC       the holoenzyme telomerase ribonucleoprotein complex suggests that it
CC       may play a role in turnover of holoenzyme telomerase complex components
CC       (PubMed:17220281). {ECO:0000250|UniProtKB:P63208,
CC       ECO:0000269|PubMed:17220281}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC       {ECO:0000250|UniProtKB:P63208}.
CC   -!- SUBUNIT: Component of multiple SCF (SKP1-CUL1-F-box) E3 ubiquitin-
CC       protein ligase complexes formed of CUL1, SKP1, RBX1 and a variable F-
CC       box domain-containing protein as substrate-specific subunit.
CC       {ECO:0000305|PubMed:17220281}.
CC   -!- DISRUPTION PHENOTYPE: Increased telomere length.
CC       {ECO:0000269|PubMed:17220281}.
CC   -!- SIMILARITY: Belongs to the SKP1 family. {ECO:0000305}.
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DR   EMBL; AY522577; AAS97867.1; -; mRNA.
DR   EMBL; GG662724; EAR93565.2; -; Genomic_DNA.
DR   RefSeq; XP_001013810.2; XM_001013810.2.
DR   AlphaFoldDB; A0PGB3; -.
DR   SMR; A0PGB3; -.
DR   STRING; 5911.EAR93565; -.
DR   EnsemblProtists; EAR93565; EAR93565; TTHERM_00426320.
DR   GeneID; 7834346; -.
DR   KEGG; tet:TTHERM_00426320; -.
DR   eggNOG; KOG1724; Eukaryota.
DR   HOGENOM; CLU_059252_6_1_1; -.
DR   OrthoDB; 1412723at2759; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000009168; Unassembled WGS sequence.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR016897; SKP1.
DR   InterPro; IPR001232; SKP1-like.
DR   InterPro; IPR036296; SKP1-like_dim_sf.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   InterPro; IPR016072; Skp1_comp_dimer.
DR   InterPro; IPR016073; Skp1_comp_POZ.
DR   PANTHER; PTHR11165; PTHR11165; 1.
DR   Pfam; PF01466; Skp1; 1.
DR   Pfam; PF03931; Skp1_POZ; 1.
DR   PIRSF; PIRSF028729; E3_ubiquit_lig_SCF_Skp; 1.
DR   SMART; SM00512; Skp1; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
DR   SUPFAM; SSF81382; SSF81382; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Ubl conjugation pathway.
FT   CHAIN           1..166
FT                   /note="S-phase kinase-associated protein 1 homolog"
FT                   /id="PRO_0000449916"
FT   REGION          105..166
FT                   /note="Interaction with the F-box domain of F-box proteins"
FT                   /evidence="ECO:0000250|UniProtKB:Q39255"
SQ   SEQUENCE   166 AA;  18973 MW;  BA530F77E4B55102 CRC64;
     MDKGSTKVKL LSLENEIIEV DEEVAKKSQL IKNMIEDTGT EDDIPIPNVK KEILLKILEY
     CEKHKNDNPP EIEKPLTTSN LSELVDPYDA KFIDIENLEQ LFEIILAANY LDIKSLLDLA
     CAKVATLIKN KTPDEIRKTF NIPNDFTPEE EAQIREENKW AEEATS