ID   SKP1_XENLA              Reviewed;         163 AA.
AC   Q71U00;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=S-phase kinase-associated protein 1;
DE   AltName: Full=Cyclin-A/CDK2-associated protein p19;
DE   AltName: Full=S-phase kinase-associated protein 1A;
DE   AltName: Full=p19A;
DE   AltName: Full=p19skp1;
GN   Name=skp1; Synonyms=skp1a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND POSSIBLE INTERACTION WITH MTUS1; FBX28;
RP   FBXO43; FBL5 AND FBL13.
RC   TISSUE=Oocyte;
RX   PubMed=10531041; DOI=10.1016/s0960-9822(00)80006-8;
RA   Regan-Reimann J.D., Duong Q.V., Jackson P.K.;
RT   "Identification of novel F-box proteins in Xenopus laevis.";
RL   Curr. Biol. 9:R762-R763(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Lorca T., Castro A., Labbe J.-C.;
RT   "Xenopus translin is present in a Skp1 complex.";
RL   Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   INTERACTION WITH MTUS1, AND IDENTIFICATION BY MASS SPECTROMETRY.
RX   PubMed=12919681; DOI=10.1016/s1534-5807(03)00229-6;
RA   Ohi R., Coughlin M.L., Lane W.S., Mitchison T.J.;
RT   "An inner centromere protein that stimulates the microtubule depolymerizing
RT   activity of a KinI kinesin.";
RL   Dev. Cell 5:309-321(2003).
CC   -!- FUNCTION: Essential component of the SCF (SKP1-CUL1-F-box protein)
CC       ubiquitin ligase complex, which mediates the ubiquitination of proteins
CC       involved in cell cycle progression, signal transduction and
CC       transcription. In the SCF complex, serves as an adapter that links the
CC       F-box protein to CUL1 (By similarity). {ECO:0000250}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- SUBUNIT: Interacts directly with CUL1 and F-box proteins, such as BTRC
CC       and SKP2, in the SCF complex (By similarity). Interacts with mtus1. May
CC       interact with fbx28, fbxo43, fbl5 and fbl13. {ECO:0000250,
CC       ECO:0000269|PubMed:12919681}.
CC   -!- SIMILARITY: Belongs to the SKP1 family. {ECO:0000305}.
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DR   EMBL; AF176352; AAF14553.1; -; mRNA.
DR   EMBL; AF169342; AAF65619.1; -; mRNA.
DR   EMBL; BC054184; AAH54184.1; -; mRNA.
DR   RefSeq; NP_001080844.1; NM_001087375.1.
DR   RefSeq; XP_018110402.1; XM_018254913.1.
DR   RefSeq; XP_018110404.1; XM_018254915.1.
DR   AlphaFoldDB; Q71U00; -.
DR   SMR; Q71U00; -.
DR   BioGRID; 98780; 4.
DR   IntAct; Q71U00; 2.
DR   DNASU; 380538; -.
DR   GeneID; 108712619; -.
DR   GeneID; 380538; -.
DR   KEGG; xla:108712619; -.
DR   CTD; 108712619; -.
DR   CTD; 380538; -.
DR   Xenbase; XB-GENE-919643; skp1.L.
DR   Xenbase; XB-GENE-17344373; skp1.S.
DR   OrthoDB; 1412723at2759; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000186698; Chromosome 3S.
DR   Bgee; 108712619; Expressed in gastrula and 19 other tissues.
DR   GO; GO:0031467; C:Cul7-RING ubiquitin ligase complex; ISS:UniProtKB.
DR   GO; GO:0019005; C:SCF ubiquitin ligase complex; ISS:UniProtKB.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR016897; SKP1.
DR   InterPro; IPR001232; SKP1-like.
DR   InterPro; IPR036296; SKP1-like_dim_sf.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   InterPro; IPR016072; Skp1_comp_dimer.
DR   InterPro; IPR016073; Skp1_comp_POZ.
DR   PANTHER; PTHR11165; PTHR11165; 1.
DR   Pfam; PF01466; Skp1; 1.
DR   Pfam; PF03931; Skp1_POZ; 1.
DR   PIRSF; PIRSF028729; E3_ubiquit_lig_SCF_Skp; 1.
DR   SMART; SM00512; Skp1; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
DR   SUPFAM; SSF81382; SSF81382; 1.
PE   1: Evidence at protein level;
KW   Reference proteome; Ubl conjugation pathway.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..163
FT                   /note="S-phase kinase-associated protein 1"
FT                   /id="PRO_0000187254"
FT   REGION          63..83
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          104..163
FT                   /note="Interaction with the F-box domain of F-box proteins"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   163 AA;  18658 MW;  C794D62AFB75528A CRC64;
     MPSIKLQSSD GEIFEVDVEI AKQSVTIKTM LEDLGMDDEG DDDPVPLPNV NAAILKKVIQ
     WCTHHKDDPP PPEDDENKEK RTDDIPVWDQ EFLKVDQGTL FELILAANYL DIKGLLDVTC
     KTVANMIKGK TPEEIRKTFN IKNDFTEEEE AQVRKENQWC EEK