SKR1B_DANRE
ID SKR1B_DANRE Reviewed; 751 AA.
AC Q1LXZ9; A4IFZ1;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2006, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=SKI family transcriptional corepressor 1 homolog-B;
DE AltName: Full=Ladybird homeobox corepressor 1 homolog-B;
GN Name=skor1b; Synonyms=lbxcor1; ORFNames=si:dkey-246a16.3;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=WIK;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May inhibit BMP signaling. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SKI family. {ECO:0000305}.
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DR EMBL; BX247951; CAK10800.1; -; Genomic_DNA.
DR EMBL; BC134846; AAI34847.1; -; mRNA.
DR RefSeq; NP_001038598.1; NM_001045133.1.
DR RefSeq; XP_005159191.1; XM_005159134.3.
DR RefSeq; XP_005159192.1; XM_005159135.3.
DR RefSeq; XP_009291861.1; XM_009293586.2.
DR AlphaFoldDB; Q1LXZ9; -.
DR SMR; Q1LXZ9; -.
DR STRING; 7955.ENSDARP00000122471; -.
DR PaxDb; Q1LXZ9; -.
DR Ensembl; ENSDART00000138103; ENSDARP00000122471; ENSDARG00000062448.
DR GeneID; 567457; -.
DR KEGG; dre:567457; -.
DR CTD; 567457; -.
DR ZFIN; ZDB-GENE-050419-82; skor1b.
DR eggNOG; ENOG502QQC2; Eukaryota.
DR GeneTree; ENSGT00940000158440; -.
DR HOGENOM; CLU_011930_1_1_1; -.
DR InParanoid; Q1LXZ9; -.
DR OMA; TKSFNGQ; -.
DR OrthoDB; 1034068at2759; -.
DR PhylomeDB; Q1LXZ9; -.
DR TreeFam; TF324133; -.
DR PRO; PR:Q1LXZ9; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 18.
DR Bgee; ENSDARG00000062448; Expressed in brain and 7 other tissues.
DR ExpressionAtlas; Q1LXZ9; baseline.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005667; C:transcription regulator complex; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0046332; F:SMAD binding; IBA:GO_Central.
DR GO; GO:0030514; P:negative regulation of BMP signaling pathway; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 3.10.260.20; -; 1.
DR Gene3D; 3.10.390.10; -; 1.
DR InterPro; IPR014890; c-SKI_SMAD4-bd_dom.
DR InterPro; IPR009061; DNA-bd_dom_put_sf.
DR InterPro; IPR010919; SAND-like_dom_sf.
DR InterPro; IPR003380; SKI/SNO/DAC.
DR InterPro; IPR037000; Ski_DNA-bd_sf.
DR InterPro; IPR023216; Tscrpt_reg_SKI_SnoN.
DR PANTHER; PTHR10005; PTHR10005; 1.
DR Pfam; PF08782; c-SKI_SMAD_bind; 1.
DR Pfam; PF02437; Ski_Sno; 1.
DR SMART; SM01046; c-SKI_SMAD_bind; 1.
DR SUPFAM; SSF46955; SSF46955; 1.
DR SUPFAM; SSF63763; SSF63763; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Nucleus; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..751
FT /note="SKI family transcriptional corepressor 1 homolog-B"
FT /id="PRO_0000334610"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 234..267
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 386..434
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 459..569
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 600..635
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 666..704
FT /evidence="ECO:0000255"
FT COMPBIAS 240..262
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 391..411
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 412..427
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 475..489
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 498..518
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 520..561
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 603..635
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 720
FT /note="Missing (in Ref. 2; AAI34847)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 751 AA; 84682 MW; AEBBAD4ABB9FC175 CRC64;
MESIPNQLPA GRDSSCSPNS KDLQSYSGPP LKPNQVSETS LYGIPIVSLV IDGQERLCLA
QISNTLLKNY SYNEIHNRRV ALGITCVQCT PVQLEILRRA GAMPISSRRC GMITKREAER
LCKSFLGAHS PPKLPENFAF DVSHECAWGS RGNFIPARYN SSRAKCIKCS FCNMYFSPNK
FIFHSHRTPE SKYTQPDAAN FNSWRRHLKL SDKNSSDDVI HAWEDVKAMF NGGSRKRTLP
IGRSESSPSQ PPRGQTQGEP SDVPHKTLRC EDDRVNVTMP SSIRSYPVIP VPSKSFGMLQ
KIPPPLFPHP YGFPAFGLCQ KKDDGEVMGE PNKTNLSGVF WPSPKDSAYT SFPMFWPTTG
SLAMPTYHHA QPKPPSDVLC ARHNELDVSE QSDRSTSTPK DSLLDNERCS STQSTRNEED
KSGDESRSIE GIPPTSRKIS YISAFRPVVK DVESIAKLYG NRGPYSGPRS GYMSPDFLSE
SSSYRSVSPD VDSVDDPDVD VESHKAHEDE ECLQLSVDDR RSPHSLTLAQ SEGVKGQDQE
NTQMHTLNDL HSTNSSETRP SDMESHGNKH TTRFEVYARE RDEHVHQMST SYFGSATTYQ
RETSVKDVHE EEPSSTVEEM EPKNHQDENN ISEERLKEPN DVCADEEAIC KDTGNRGSLI
EKNIESMAKE ELQKQLVEQV ELRKKLEREF QNLKDSFQDQ MKRELSYREE MVQQLQIVRE
AHDALHHFSC KMLTPRHCTG TCTFKPPLLP P
