SL172_CAEEL
ID SL172_CAEEL Reviewed; 493 AA.
AC Q03567;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 2.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Uncharacterized transporter slc-17.2 {ECO:0000305};
GN ORFNames=C38C10.2 {ECO:0000312|WormBase:C38C10.2};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=7906398; DOI=10.1038/368032a0;
RA Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J.,
RA Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M.,
RA Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A.,
RA Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M.,
RA Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C.,
RA Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A.,
RA Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M.,
RA Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K.,
RA Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L.,
RA Wilkinson-Sproat J., Wohldman P.;
RT "2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
RT elegans.";
RL Nature 368:32-38(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [3]
RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-69, AND IDENTIFICATION BY MASS
RP SPECTROMETRY.
RC STRAIN=Bristol N2;
RX PubMed=17761667; DOI=10.1074/mcp.m600392-mcp200;
RA Kaji H., Kamiie J., Kawakami H., Kido K., Yamauchi Y., Shinkawa T.,
RA Taoka M., Takahashi N., Isobe T.;
RT "Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis
RT elegans and suggests an atypical translocation mechanism for integral
RT membrane proteins.";
RL Mol. Cell. Proteomics 6:2100-2109(2007).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Sodium/anion
CC cotransporter family. {ECO:0000305}.
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DR EMBL; Z19153; CAA79549.1; -; Genomic_DNA.
DR PIR; G88553; G88553.
DR PIR; S28286; S28286.
DR RefSeq; NP_499065.1; NM_066664.4.
DR AlphaFoldDB; Q03567; -.
DR SMR; Q03567; -.
DR STRING; 6239.C38C10.2; -.
DR iPTMnet; Q03567; -.
DR EPD; Q03567; -.
DR PaxDb; Q03567; -.
DR PeptideAtlas; Q03567; -.
DR EnsemblMetazoa; C38C10.2.1; C38C10.2.1; WBGene00008000.
DR GeneID; 176317; -.
DR KEGG; cel:CELE_C38C10.2; -.
DR UCSC; C38C10.2.1; c. elegans.
DR CTD; 176317; -.
DR WormBase; C38C10.2; CE08647; WBGene00008000; slc-17.2.
DR eggNOG; KOG2532; Eukaryota.
DR GeneTree; ENSGT00940000163850; -.
DR HOGENOM; CLU_001265_5_0_1; -.
DR InParanoid; Q03567; -.
DR OMA; EWQVVLW; -.
DR OrthoDB; 619250at2759; -.
DR PhylomeDB; Q03567; -.
DR Reactome; R-CEL-4085001; Sialic acid metabolism.
DR Reactome; R-CEL-428643; Organic anion transporters.
DR PRO; PR:Q03567; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00008000; Expressed in embryo and 4 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0006820; P:anion transport; IBA:GO_Central.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1250.20; -; 2.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
PE 1: Evidence at protein level;
KW Glycoprotein; Ion transport; Membrane; Reference proteome; Sodium;
KW Sodium transport; Symport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..493
FT /note="Uncharacterized transporter slc-17.2"
FT /evidence="ECO:0000305"
FT /id="PRO_0000220950"
FT TRANSMEM 10..30
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 85..105
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 112..132
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 144..164
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 175..195
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 205..225
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 311..331
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 348..368
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 375..395
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 406..426
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 441..461
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 35
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 47
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 69
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:17761667"
FT CARBOHYD 305
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 433
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 493 AA; 52737 MW; 60792715D32553DD CRC64;
MEGATTKPRL VPSTRFALSL VMFFGCLVTY MMRTNMSFAV VCMVNENKTD TGVEKVSRCG
KEMTPVESNS SVIGEFDWDK QTTGMVLSSF FYGYIGSQII GGHLASRYGG KRVVFVTILG
SALLTLLNPV AARTSEYALA ILRAAIGFLQ GATFPAMHTM WSVWGPPLEL SVLTGVTYAG
AQIGNVIVLP LSGFLCEYGF DGGWPSIFYI IGVFGVLWTA VWWYVSSDKP ATHPRITPEE
KQYIVTAVEA SMGKDTGKVP STPWIKILTS PAVWACWAGH FAGDWGAYTM LVSLPSFLKD
VLGLNLSSLG AVASIPYIAY FLAINAGGVL ADTLRSKGIL STLNTRRAAM LVALIGQGIF
LVASGYCGCG QDVLVIIFIT CGMAISGLQY AGFVVNYLEI APPFSGTVMG TGNTISALAG
IISPAVSSYL TPNGTQEEWQ MVLWLTAGIL TIGALLFSIF ASGEVQPWAK LTAEEGHEMA
PLREGEKIEL ATA
