SL173_CAEEL
ID SL173_CAEEL Reviewed; 535 AA.
AC P34272;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 29-APR-2008, sequence version 2.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Uncharacterized transporter slc-17.3 {ECO:0000305};
GN Name=slc-17.3 {ECO:0000312|WormBase:C02C2.4};
GN ORFNames=C02C2.4 {ECO:0000312|WormBase:C02C2.4};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=7906398; DOI=10.1038/368032a0;
RA Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J.,
RA Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M.,
RA Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A.,
RA Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M.,
RA Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C.,
RA Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A.,
RA Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M.,
RA Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K.,
RA Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L.,
RA Wilkinson-Sproat J., Wohldman P.;
RT "2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
RT elegans.";
RL Nature 368:32-38(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Sodium/anion
CC cotransporter family. {ECO:0000305}.
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DR EMBL; FO080276; CCD62531.1; -; Genomic_DNA.
DR PIR; S44742; S44742.
DR RefSeq; NP_498709.2; NM_066308.3.
DR AlphaFoldDB; P34272; -.
DR SMR; P34272; -.
DR PaxDb; P34272; -.
DR EnsemblMetazoa; C02C2.4.1; C02C2.4.1; WBGene00015333.
DR GeneID; 182107; -.
DR KEGG; cel:CELE_C02C2.4; -.
DR UCSC; C02C2.4; c. elegans.
DR CTD; 182107; -.
DR WormBase; C02C2.4; CE41976; WBGene00015333; slc-17.3.
DR eggNOG; KOG2532; Eukaryota.
DR HOGENOM; CLU_001265_5_0_1; -.
DR InParanoid; P34272; -.
DR OMA; FVDCSNP; -.
DR OrthoDB; 802408at2759; -.
DR PhylomeDB; P34272; -.
DR PRO; PR:P34272; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00015333; Expressed in larva and 2 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1250.20; -; 2.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
PE 3: Inferred from homology;
KW Glycoprotein; Ion transport; Membrane; Reference proteome; Sodium;
KW Sodium transport; Symport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..535
FT /note="Uncharacterized transporter slc-17.3"
FT /evidence="ECO:0000305"
FT /id="PRO_0000220942"
FT TRANSMEM 17..37
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 107..127
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 144..164
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 167..187
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 199..219
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 225..245
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 292..312
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 331..351
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 368..388
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 395..415
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 429..451
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 463..483
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 44
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 61
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 329
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 535 AA; 59250 MW; 2D9CA9D696CFA724 CRC64;
MAKKFPLFHP FSRRLHIVLL CMIGFFCTTF MRIHFALTMT CMVNSTALAV ENEIKLAGNS
NVSEISIIEE INLGSNGQCG LMDEDGQKKV VVDYGGELVW NSYEQNLIFS GTFWGSLITV
LPSMFFIERF SPRHVLQISV ALYILVTVIT PFLATHFGYF SVFLARIGMG LGEGFVFPTN
NAIIGNWFPS SEKSTALSIF TLGNQIASAA GSPMVAAVCA SDLGWPATFY FAGIFATGWS
ILWFFTASSH PAKVKMMTKK EKEYLLANVV KKVHKSEKTR SIPYSKILTS PAFLGQLQCH
FFVNLFMTLF QIYLPSYFKE VLHLGVIANG TFTAIPNIFN MIFKVVWGIG IDKLKENKIL
SNTKAVKVSH GVASFGSSFS LILLAFFVDC SNPTTGLIFF CLMYSSMGTF VSGFYTSLLS
LAPQYTATMS AISMFVAMIG RLTTPAVMSM FRKDGTAAEW QNIFIGCSLA HIFSGSIFLL
FGSGELQDWA KVEDDQEMNE KEKLKTIENG IVVVEEVDVK NEMSATLVKE DSLCL
