SL2_BITGA
ID SL2_BITGA Reviewed; 156 AA.
AC Q6T7B6;
DT 25-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 53.
DE RecName: Full=Snaclec 2;
DE AltName: Full=C-type lectin 2;
DE Flags: Precursor;
OS Bitis gabonica (Gaboon adder) (Gaboon viper).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Viperidae; Viperinae; Bitis.
OX NCBI_TaxID=8694;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 22-41.
RC TISSUE=Venom, and Venom gland;
RX PubMed=15276202; DOI=10.1016/j.gene.2004.03.024;
RA Francischetti I.M.B., My-Pham V., Harrison J., Garfield M.K.,
RA Ribeiro J.M.C.;
RT "Bitis gabonica (Gaboon viper) snake venom gland: toward a catalog for the
RT full-length transcripts (cDNA) and proteins.";
RL Gene 337:55-69(2004).
CC -!- FUNCTION: Interferes with one step of hemostasis (modulation of
CC platelet aggregation, or coagulation cascade, for example).
CC {ECO:0000250}.
CC -!- SUBUNIT: Heterodimer; disulfide-linked. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC -!- SIMILARITY: Belongs to the snaclec family. {ECO:0000305}.
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DR EMBL; AY429478; AAR06852.1; -; mRNA.
DR AlphaFoldDB; Q6T7B6; -.
DR SMR; Q6T7B6; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR Gene3D; 3.10.100.10; -; 1.
DR InterPro; IPR001304; C-type_lectin-like.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR016187; CTDL_fold.
DR Pfam; PF00059; Lectin_C; 1.
DR SMART; SM00034; CLECT; 1.
DR SUPFAM; SSF56436; SSF56436; 1.
DR PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Disulfide bond; Hemostasis impairing toxin;
KW Secreted; Signal; Toxin.
FT SIGNAL 1..21
FT /evidence="ECO:0000250"
FT CHAIN 22..156
FT /note="Snaclec 2"
FT /id="PRO_0000355249"
FT DOMAIN 32..151
FT /note="C-type lectin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT DISULFID 25..36
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT DISULFID 53..150
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT DISULFID 102
FT /note="Interchain"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT DISULFID 125..142
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
SQ SEQUENCE 156 AA; 18157 MW; 1A50D1795904C5B2 CRC64;
MGRFIFLSSG LLVVFLSLSG ADFECPSEWR PFDQHCYRAF DEPKRSADAE KFCSEQGNSG
HLVSIQSKEE ADFVAQLISD NIKSSPDYVW MGLWNQRREQ YCSRKWTDGS NVIYKNVAER
FTKNCFGLEK ETEYRTWLNI LCGDDYPFVC KFPPRC