BHLH9_MOUSE
ID BHLH9_MOUSE Reviewed; 539 AA.
AC Q6PB60; Q3U0C1; Q69ZD0;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Protein BHLHb9;
DE Short=bHLHb9;
GN Name=Bhlhb9; Synonyms=Kiaa1701;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Pancreatic islet;
RX PubMed=15368895; DOI=10.1093/dnares/11.3.205;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S.,
RA Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H.,
RA Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: IV.
RT The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 11:205-218(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-220.
RC STRAIN=C57BL/6J, and NOD; TISSUE=Spleen;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- FUNCTION: May play a role in the control of cellular aging and
CC survival. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC Note=Mainly cytoplasmic, and nuclear at lower level. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the GPRASP family. {ECO:0000305}.
CC -!- CAUTION: Despite its name, no basic helix-loop-helix (bHLH) domain is
CC detected by any prediction tool. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAD32514.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAD32514.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK173236; BAD32514.1; ALT_SEQ; mRNA.
DR EMBL; AL683822; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC059871; AAH59871.1; -; mRNA.
DR EMBL; AK143861; BAE25572.1; -; mRNA.
DR EMBL; AK157023; BAE33934.1; -; mRNA.
DR CCDS; CCDS30410.1; -.
DR RefSeq; NP_001091692.1; NM_001098222.1.
DR RefSeq; NP_937804.1; NM_198161.2.
DR RefSeq; XP_006528670.1; XM_006528607.2.
DR RefSeq; XP_006528671.1; XM_006528608.2.
DR RefSeq; XP_011246062.1; XM_011247760.1.
DR AlphaFoldDB; Q6PB60; -.
DR SMR; Q6PB60; -.
DR STRING; 10090.ENSMUSP00000068067; -.
DR iPTMnet; Q6PB60; -.
DR PhosphoSitePlus; Q6PB60; -.
DR EPD; Q6PB60; -.
DR MaxQB; Q6PB60; -.
DR PaxDb; Q6PB60; -.
DR PRIDE; Q6PB60; -.
DR ProteomicsDB; 273608; -.
DR DNASU; 70237; -.
DR Ensembl; ENSMUST00000068755; ENSMUSP00000068067; ENSMUSG00000072964.
DR Ensembl; ENSMUST00000180025; ENSMUSP00000137213; ENSMUSG00000072964.
DR GeneID; 70237; -.
DR KEGG; mmu:70237; -.
DR UCSC; uc009uhv.1; mouse.
DR CTD; 80823; -.
DR MGI; MGI:1917487; Bhlhb9.
DR VEuPathDB; HostDB:ENSMUSG00000072964; -.
DR eggNOG; ENOG502RU0K; Eukaryota.
DR GeneTree; ENSGT00940000161990; -.
DR HOGENOM; CLU_036908_0_0_1; -.
DR InParanoid; Q6PB60; -.
DR OMA; PIPEYPF; -.
DR PhylomeDB; Q6PB60; -.
DR TreeFam; TF335652; -.
DR BioGRID-ORCS; 70237; 2 hits in 73 CRISPR screens.
DR ChiTaRS; Bhlhb9; mouse.
DR PRO; PR:Q6PB60; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; Q6PB60; protein.
DR Bgee; ENSMUSG00000072964; Expressed in manus and 255 other tissues.
DR ExpressionAtlas; Q6PB60; baseline and differential.
DR Genevisible; Q6PB60; MM.
DR GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0042803; F:protein homodimerization activity; IDA:UniProtKB.
DR GO; GO:0007611; P:learning or memory; IDA:UniProtKB.
DR GO; GO:0043524; P:negative regulation of neuron apoptotic process; IDA:UniProtKB.
DR GO; GO:0061003; P:positive regulation of dendritic spine morphogenesis; IDA:UniProtKB.
DR GO; GO:0050769; P:positive regulation of neurogenesis; IDA:UniProtKB.
DR GO; GO:0051965; P:positive regulation of synapse assembly; IDA:UniProtKB.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR006911; ARM-rpt_dom.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR043374; BHLHb9/GASP-1/GASP-2.
DR PANTHER; PTHR46414; PTHR46414; 1.
DR Pfam; PF04826; Arm_2; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Nucleus; Reference proteome.
FT CHAIN 1..539
FT /note="Protein BHLHb9"
FT /id="PRO_0000334664"
FT REGION 1..112
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 134..172
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..23
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 34..52
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 64..109
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 134..150
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 152..168
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 539 AA; 59823 MW; 9484323DCF690453 CRC64;
MTGSKNKARA QAKLEKRASA QARAVAEREA ANANRGAGKS RDKGKGKAGS KSDAVAEVKA
GSKGKVVAET KEGARPESKA LVKGTSDFNH RTENKFARST RKDKPSSDNW FWAGEDSGIN
SWFWKGEELS NNSVAKCENK PSTSIQARAE EPAPRTSHKS RSGAEEEEEE NVIGNWFWEG
DDTGFDTDPK PVFKIVKPQP VDEINEKDRP KDWSEVTIWP KAPAVTPAVL GYRSQDSSEA
RSSSYIVLAS NEEETSTACT KNTRSSLQSI PEYPFGSDPC IQTLDEIRQQ IKIREENGIK
PFACPCKLEC YLDSPEFEKL VNILKSTTDP LIHKIAQIAM GIHKVHPFAQ EFINEVGVVT
LIESLLSFSS PEVSIKKAVI TLNSSGDDRY NKVEFHVKHM CKETVSFPLN SPGQQSGLKI
IGQLTTESVH HYIVVSYFSE LFHLLSQGNR KTRNLVLKVF LNMSENPKAA RDMINMKALA
ALKLIFNQKE AKANLVSAVA IFINIKEHIR KGSIVVVDHL SYNTLTAIFR EVKGIIERM
