ID   SL9A2_RABIT             Reviewed;         809 AA.
AC   P50482;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=Sodium/hydrogen exchanger 2;
DE   AltName: Full=Na(+)/H(+) exchanger 2;
DE            Short=NHE-2;
DE   AltName: Full=Solute carrier family 9 member 2;
GN   Name=SLC9A2; Synonyms=NHE2;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=New Zealand white;
RX   PubMed=7685025; DOI=10.1016/s0021-9258(19)50287-3;
RA   Tse C.-M., Levine S.A., Yun C.H., Montrose M.H., Little P.J.,
RA   Pouyssegur J., Donowitz M.;
RT   "Cloning and expression of a rabbit cDNA encoding a serum-activated
RT   ethylisopropylamiloride-resistant epithelial Na+/H+ exchanger isoform (NHE-
RT   2).";
RL   J. Biol. Chem. 268:11917-11924(1993).
CC   -!- FUNCTION: Involved in pH regulation to eliminate acids generated by
CC       active metabolism or to counter adverse environmental conditions. Major
CC       proton extruding system driven by the inward sodium ion chemical
CC       gradient. Seems to play an important role in colonic sodium absorption.
CC   -!- SUBUNIT: Interacts with CHP1 and CHP2. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- TISSUE SPECIFICITY: High levels in intestine and kidney.
CC   -!- PTM: Phosphorylated (Possible).
CC   -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 1 (CPA1)
CC       transporter (TC 2.A.36) family. {ECO:0000305}.
CC   -!- CAUTION: The number, localization and denomination of hydrophobic
CC       domains in the Na(+)/H(+) exchangers vary among authors. {ECO:0000305}.
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DR   EMBL; L13733; -; NOT_ANNOTATED_CDS; mRNA.
DR   PIR; A46747; A46747.
DR   AlphaFoldDB; P50482; -.
DR   SMR; P50482; -.
DR   STRING; 9986.ENSOCUP00000004232; -.
DR   BindingDB; P50482; -.
DR   ChEMBL; CHEMBL3770; -.
DR   PRIDE; P50482; -.
DR   eggNOG; KOG1966; Eukaryota.
DR   InParanoid; P50482; -.
DR   Proteomes; UP000001811; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015385; F:sodium:proton antiporter activity; IEA:InterPro.
DR   GO; GO:0006885; P:regulation of pH; IEA:InterPro.
DR   InterPro; IPR006153; Cation/H_exchanger.
DR   InterPro; IPR018422; Cation/H_exchanger_CPA1.
DR   InterPro; IPR004709; NaH_exchanger.
DR   InterPro; IPR001953; NHE-2/4.
DR   InterPro; IPR032103; NHE_CaM-bd.
DR   PANTHER; PTHR10110; PTHR10110; 1.
DR   Pfam; PF00999; Na_H_Exchanger; 1.
DR   Pfam; PF16644; NEXCaM_BD; 1.
DR   PRINTS; PR01084; NAHEXCHNGR.
DR   PRINTS; PR01086; NAHEXCHNGR2.
DR   TIGRFAMs; TIGR00840; b_cpa1; 1.
PE   2: Evidence at transcript level;
KW   Antiport; Glycoprotein; Ion transport; Membrane; Phosphoprotein;
KW   Reference proteome; Sodium; Sodium transport; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..809
FT                   /note="Sodium/hydrogen exchanger 2"
FT                   /id="PRO_0000052353"
FT   TOPO_DOM        1..16
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   INTRAMEM        17..37
FT                   /note="Name=A/M1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        38..79
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   INTRAMEM        80..100
FT                   /note="Name=B/M2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        101..106
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        107..127
FT                   /note="Helical; Name=C/M3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        128..138
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        139..159
FT                   /note="Helical; Name=D/M4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        160..168
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        169..189
FT                   /note="Helical; Name=E/M5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        190..208
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        209..229
FT                   /note="Helical; Name=F/M5A"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        230..236
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        237..257
FT                   /note="Helical; Name=G/M5B"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        258..277
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        278..298
FT                   /note="Helical; Name=H/M6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        299..307
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        308..328
FT                   /note="Helical; Name=I/M7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        329..360
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        361..381
FT                   /note="Helical; Name=J/M8"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        382..391
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        392..412
FT                   /note="Helical; Name=K/M9"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        413..429
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   INTRAMEM        430..450
FT                   /note="Name=L/M10"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        451..458
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        459..479
FT                   /note="Helical; Name=M/M11"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        480..809
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          648..700
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          734..809
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        676..690
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        769..809
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        350
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   809 AA;  90745 MW;  DBD00B45443D87A6 CRC64;
     MESAGTGRSL RTPPPRLLLL LLLQVAGPAG ALAETLLNAP KAMGTSSSPL SPASVVAPGT
     TAFEESRLPV FTLDYPHVQI PFEITLWILL ASLAKIGFHL YHKLPTIVPE SCLLIMVGLL
     LGGIIFGVDE KSPPAMKTDV FFLYLLPPIV LDAGYFMPTR PFFENLGTIF WYAVVGTLWN
     SIGIGVSLFG ICQIEAFGLS DITLLQNLLF GSLISAVDPV AVLAVFENIH VNEQLYILVF
     GESLLNDAVT VVLYNLFKSF CQMKTIETID VFAGIANFFV VGIGGVLIGI FLGFIAAFTT
     RFTHNIRVIE PLFVFLYSYL SYITAEMFHL SGIMAITACA MTMNKYVEEN VSQKSYTTIK
     YFMKMLSSVS ETLIFIFMGV STVGKNHEWN WAFVCFTLAF CLIWRALGVF VLTRVINWFR
     TIPLTFKDQF IIAYGGLRGA ICFALVFLLP AAVFPRKKLF ITAAIVVIFF TVFILGITIR
     PLVEFLDVKR SNKKQQAVSE EIHCRFFDHV KTGIEDVCGH WGHNFWRDKF KKFDDKYLRK
     LLIRENQPKS SIVSLYKKLE IKHAIEMAET GMISTVPSFA SLNDCREEKI RKLTPGEMDE
     IREILSRNLY QIRQRTLSYN RHNLTADTSE RQAKEILIRR RHSLRESIRK DNSLNRERRA
     STSTSRYLSL PKNTKLPEKL QKRKNISNAD GDSSDSEADA GTTVLNLQPR ARRFLPEPFS
     KKASQAYKME WKNEVDAGSG QGQPSPPAAP RSKEGGTQTP AVLRQPLLSK DQGREDSLTE
     GGRPKPPPRL VRRASEPGNR KSRLGSDKP