SL9A5_RAT
ID SL9A5_RAT Reviewed; 898 AA.
AC Q9Z0X2;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 25-MAY-2022, entry version 124.
DE RecName: Full=Sodium/hydrogen exchanger 5;
DE AltName: Full=Na(+)/H(+) exchanger 5;
DE Short=NHE-5;
DE AltName: Full=Solute carrier family 9 member 5;
GN Name=Slc9a5; Synonyms=Nhe5;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Wistar;
RX PubMed=9933642; DOI=10.1074/jbc.274.7.4383;
RA Attaphitaya S., Park K., Melvin J.E.;
RT "Molecular cloning and functional expression of a rat Na+/H+ exchanger
RT (NHE5) highly expressed in brain.";
RL J. Biol. Chem. 274:4383-4388(1999).
RN [2]
RP INTERACTION WITH CHP1 AND CHP2.
RX PubMed=12576672; DOI=10.1248/bpb.26.148;
RA Inoue H., Nakamura Y., Nagita M., Takai T., Masuda M., Nakamura N.,
RA Kanazawa H.;
RT "Calcineurin homologous protein isoform 2 (CHP2), Na+/H+ exchangers-binding
RT protein, is expressed in intestinal epithelium.";
RL Biol. Pharm. Bull. 26:148-155(2003).
CC -!- FUNCTION: Involved in pH regulation to eliminate acids generated by
CC active metabolism or to counter adverse environmental conditions. Major
CC proton extruding system driven by the inward sodium ion chemical
CC gradient. Plays an important role in signal transduction (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with ARRB2 (By similarity). Interacts with CHP1 and
CC CHP2. {ECO:0000250, ECO:0000269|PubMed:12576672}.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Highly expressed in brain.
CC -!- PTM: Phosphorylated (Possible).
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 1 (CPA1)
CC transporter (TC 2.A.36) family. {ECO:0000305}.
CC -!- CAUTION: The number, localization and denomination of hydrophobic
CC domains in the Na(+)/H(+) exchangers vary among authors. {ECO:0000305}.
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DR EMBL; AF100172; AAD16413.1; -; mRNA.
DR RefSeq; NP_620213.1; NM_138858.1.
DR AlphaFoldDB; Q9Z0X2; -.
DR SMR; Q9Z0X2; -.
DR IntAct; Q9Z0X2; 2.
DR STRING; 10116.ENSRNOP00000063061; -.
DR GlyGen; Q9Z0X2; 2 sites.
DR PhosphoSitePlus; Q9Z0X2; -.
DR PaxDb; Q9Z0X2; -.
DR GeneID; 192215; -.
DR KEGG; rno:192215; -.
DR UCSC; RGD:620473; rat.
DR CTD; 6553; -.
DR RGD; 620473; Slc9a5.
DR eggNOG; KOG1966; Eukaryota.
DR InParanoid; Q9Z0X2; -.
DR OrthoDB; 389547at2759; -.
DR Reactome; R-RNO-425986; Sodium/Proton exchangers.
DR PRO; PR:Q9Z0X2; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0015386; F:potassium:proton antiporter activity; IBA:GO_Central.
DR GO; GO:0015385; F:sodium:proton antiporter activity; IDA:RGD.
DR GO; GO:0071805; P:potassium ion transmembrane transport; IBA:GO_Central.
DR GO; GO:1902600; P:proton transmembrane transport; IDA:RGD.
DR GO; GO:0051453; P:regulation of intracellular pH; IBA:GO_Central.
DR GO; GO:0098719; P:sodium ion import across plasma membrane; IBA:GO_Central.
DR GO; GO:0006814; P:sodium ion transport; IDA:RGD.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR018422; Cation/H_exchanger_CPA1.
DR InterPro; IPR018410; Na/H_exchanger_3/5.
DR InterPro; IPR004709; NaH_exchanger.
DR PANTHER; PTHR10110; PTHR10110; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR PRINTS; PR01084; NAHEXCHNGR.
DR PRINTS; PR01087; NAHEXCHNGR3.
DR TIGRFAMs; TIGR00840; b_cpa1; 1.
PE 1: Evidence at protein level;
KW Antiport; Glycoprotein; Ion transport; Membrane; Phosphoprotein;
KW Reference proteome; Sodium; Sodium transport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..898
FT /note="Sodium/hydrogen exchanger 5"
FT /id="PRO_0000052361"
FT TRANSMEM 4..24
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 48..68
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 76..96
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 137..157
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 176..196
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 203..223
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 249..269
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 279..299
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 334..354
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 363..383
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 401..421
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 431..451
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 660..692
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 801..888
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 811..826
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 851..865
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 201
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 321
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 898 AA; 99052 MW; 0D959DD3F18831CB CRC64;
MLRVALLLLP GLPLAGVGAT EEPTQEPGPL GEPPGLALFR WQWHEVEAPY LVALWILVAS
LAKIVFHLSR KVTSLVPESC LLILLGLALG GIVLAVAKKA EYQLEPGTFF LFLLPPIVLD
SGYFMPSRLF FDNLGAILTY AVVGTLWNAF TTGVALWGLQ QAGLVAPRVQ AGLLDFLLFG
SLISAVDPVA VLAVFEEVHV NETLFIIVFG ESLLNDAVTA VLYKVCNSFV EMGSANVQAT
DYLKGVASLF VVSLGGAAVG LVFAFLLALT TRFTKRVRII EPLLVFLLAY AAYLTAEMAS
LSAILAVTMC GLGCKKYVEA NISHKSRTAV KYTMKTLASS AETVIFMLLG ISAVDSSKWA
WDSGLVLGTL FFILFFRALG VVLQTWVLNQ FRLAPLDKID QVVMSYGGLR GAVAFALVIL
LDRTKVPAKD YFVATTIVVV FFTVIVQGLT IKPLVKWLRV KRSDYHKPTL NQELHEHTFD
HILAAVEDVV GHHGYHYWRD RWEQFDKKYL SQLLMRRSAY RIRDQIWDVY YRLNIRDAIS
FVDQGGHVLS SAGLTLPSMP SRNSVAETSV TNLLRESGSG ACLDLQVIDT VRSGRDREDA
VMHHLLCGGL YKPRRRYKAS CSRHFISEDA QERQDKEVFQ QNMKRRLESF KSTKHNICFT
KSKPRPRKTG HKKKDGVANP EATNGKPPRD LGFQDTAAVI LTVESEEEEE SESSETEKED
DEGIIFVARA TSEVLQEGKV SGSLEVCPSP RIIPPSPTCA EKELPWKSGQ GDLAVYVSSE
TTKIVPVDMQ TGWNQSISSL ESLASPPCTQ PPTLTRLPPH PLVPEEPQVP LDLSSDPRSS
FAFPPSLAKA GRSRSESSAD IPQQQELQPL MGHKDHTHLS PGPANSHWCI QFNRGGRL
