ID   SL9A8_CHICK             Reviewed;         574 AA.
AC   Q5ZJ75;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Sodium/hydrogen exchanger 8;
DE   AltName: Full=Na(+)/H(+) exchanger 8;
DE            Short=NHE-8;
DE   AltName: Full=Solute carrier family 9 member 8;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Involved in pH regulation to eliminate acids generated by
CC       active metabolism or to counter adverse environmental conditions. Major
CC       proton extruding system driven by the inward sodium ion chemical
CC       gradient. Plays an important role in signal transduction (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Multi-
CC       pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 1 (CPA1)
CC       transporter (TC 2.A.36) family. {ECO:0000305}.
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DR   EMBL; AJ720559; CAG32218.1; -; mRNA.
DR   RefSeq; NP_001034364.1; NM_001039275.2.
DR   AlphaFoldDB; Q5ZJ75; -.
DR   SMR; Q5ZJ75; -.
DR   STRING; 9031.ENSGALP00000013041; -.
DR   PaxDb; Q5ZJ75; -.
DR   GeneID; 419356; -.
DR   KEGG; gga:419356; -.
DR   CTD; 23315; -.
DR   VEuPathDB; HostDB:geneid_419356; -.
DR   eggNOG; KOG1965; Eukaryota.
DR   PhylomeDB; Q5ZJ75; -.
DR   PRO; PR:Q5ZJ75; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015386; F:potassium:proton antiporter activity; IBA:GO_Central.
DR   GO; GO:0015385; F:sodium:proton antiporter activity; IBA:GO_Central.
DR   GO; GO:0071805; P:potassium ion transmembrane transport; IBA:GO_Central.
DR   GO; GO:0051453; P:regulation of intracellular pH; IBA:GO_Central.
DR   InterPro; IPR006153; Cation/H_exchanger.
DR   InterPro; IPR018422; Cation/H_exchanger_CPA1.
DR   InterPro; IPR004709; NaH_exchanger.
DR   PANTHER; PTHR10110; PTHR10110; 1.
DR   Pfam; PF00999; Na_H_Exchanger; 1.
DR   PRINTS; PR01084; NAHEXCHNGR.
DR   TIGRFAMs; TIGR00840; b_cpa1; 1.
PE   2: Evidence at transcript level;
KW   Antiport; Golgi apparatus; Ion transport; Membrane; Reference proteome;
KW   Sodium; Sodium transport; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..574
FT                   /note="Sodium/hydrogen exchanger 8"
FT                   /id="PRO_0000379804"
FT   TRANSMEM        53..73
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        77..97
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        116..136
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        149..169
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        184..204
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        254..274
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        304..324
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        347..367
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        373..393
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        410..430
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        444..464
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   574 AA;  64133 MW;  5BAA349BA43DFC4A CRC64;
     MAEFANASHE VINVTLGTTL AATTKLVMPT PAKPILPVQT GVQAQQEEQS SGMTIFFSLL
     VLAICIILVH LLIKYRLHFL PESVAVVSLG IIMGAFIKII EAQKLANWKE EEMFRPNMFF
     LLLLPPIIFE SGYSLHKGNF FQNIGSITLF SVFGTAISAF IVGGGIYFLG QADVIYKLNM
     TDSFAFGSLI SAVDPVATIA IFNALNVDPV LNMLVFGESI LNDAVSIVLT NTAEGLTREN
     MSDVSGWQTF LQALGYFLKM FFGSAALGTL TGLISALVLK HIDLRKTPSL EFGMMIIFAY
     LPYGLAEGIS LSGIMAILFS GIVMSHYTHH NLSPVTQILM QQTLRTVAFM CETCVFAFLG
     LSIFSFPHKF EMSFVIWCIV LVLFGRAVNI FPLSYLLNFF RDHKITPKMM FIMWFSGLRG
     AIPYALSLHL GLEPIEKRQL IGTTTIIIVL FTVLLLGGGT MPLIRLIGIE DSKARKRNKK
     DVNLSKTEKM GNTIESEHLS ELTEGEYEAQ YIKRQDLKGF MWLDAKYLNP FFTRRLTQED
     LHHGRIQMKT LTNKWYEEVR QGPSGSEDDE QELL