ID   SL9A8_MACFA             Reviewed;         542 AA.
AC   Q4R8V4;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=Sodium/hydrogen exchanger 8;
DE   AltName: Full=Na(+)/H(+) exchanger 8;
DE            Short=NHE-8;
DE   AltName: Full=Solute carrier family 9 member 8;
GN   Name=SLC9A8; Synonyms=NHE8; ORFNames=QtsA-11355;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in pH regulation to eliminate acids generated by
CC       active metabolism or to counter adverse environmental conditions. Major
CC       proton extruding system driven by the inward sodium ion chemical
CC       gradient. Plays an important role in signal transduction (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Multi-
CC       pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 1 (CPA1)
CC       transporter (TC 2.A.36) family. {ECO:0000305}.
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DR   EMBL; AB168343; BAE00467.1; -; mRNA.
DR   RefSeq; NP_001270304.1; NM_001283375.1.
DR   AlphaFoldDB; Q4R8V4; -.
DR   SMR; Q4R8V4; -.
DR   Ensembl; ENSMFAT00000023434; ENSMFAP00000004768; ENSMFAG00000002040.
DR   GeneID; 101865258; -.
DR   CTD; 23315; -.
DR   GeneTree; ENSGT00940000157210; -.
DR   OrthoDB; 546232at2759; -.
DR   Proteomes; UP000233100; Chromosome 10.
DR   Bgee; ENSMFAG00000002040; Expressed in liver and 13 other tissues.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015385; F:sodium:proton antiporter activity; IEA:InterPro.
DR   GO; GO:0006885; P:regulation of pH; IEA:InterPro.
DR   InterPro; IPR006153; Cation/H_exchanger.
DR   InterPro; IPR018422; Cation/H_exchanger_CPA1.
DR   InterPro; IPR004709; NaH_exchanger.
DR   PANTHER; PTHR10110; PTHR10110; 2.
DR   Pfam; PF00999; Na_H_Exchanger; 1.
DR   PRINTS; PR01084; NAHEXCHNGR.
PE   2: Evidence at transcript level;
KW   Antiport; Golgi apparatus; Ion transport; Membrane; Phosphoprotein;
KW   Reference proteome; Sodium; Sodium transport; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..542
FT                   /note="Sodium/hydrogen exchanger 8"
FT                   /id="PRO_0000379802"
FT   TRANSMEM        60..80
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        84..104
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        123..143
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        156..176
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        191..211
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        264..284
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        299..319
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        340..360
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        378..398
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        412..432
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         471
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8R4D1"
FT   MOD_RES         532
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y2E8"
FT   MOD_RES         534
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y2E8"
SQ   SEQUENCE   542 AA;  61118 MW;  F313D66D042F1A50 CRC64;
     MGEKMAEEER FPNTTHEGFN VTLHTTLVVT TKLVLPTPGK PILPVQTGEQ AQQEEQSSGM
     TIFFSLLVLA ICIILVHLLI RYRLHFLPES VAVVSLGILM GAVIKIIEFK KLANWKEEEM
     FRPNMFFLLL LPPIIFESGY SLHKGNFFQN IGSITLFAVF GTAISAFVVG GGIYFLGQAD
     VISKLNMTDS FAFGSLISAV DPVATIAIFN ALHVDPVLNM LVFGESILND AVSIVLTNTA
     EGLTRKNMSD VSGWQTFLQA LDYFLKMFFG SAALGTLTGL ISALVLKHID LRKTPSLEFG
     MMIIFAYLPY GLAEGISLSE TCVFAFLGLS IFSFPHKFEI SFVIWCIVLV LFGRAVNIFP
     LSYLLNFFRD HKITPKMMFI MWFSGLRGAI PYALSLHLDL EPMEKRQLIG TTTIVIVLFT
     ILLLGGSTMP LIRLMDIEDA KARRRNKKDV NLSKTEKMGN TVESEHLSEL TEEEYEAHYI
     RRQDLKGFMW LDAKYLNPFF TRRLTQEDLH HGRIQMKTLT NKWYEEVRQG PSGSEDDEQE
     LL