SL9A8_RAT
ID SL9A8_RAT Reviewed; 575 AA.
AC Q4L208;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 02-AUG-2005, sequence version 1.
DT 25-MAY-2022, entry version 93.
DE RecName: Full=Sodium/hydrogen exchanger 8;
DE AltName: Full=Na(+)/H(+) exchanger 8;
DE Short=NHE-8;
DE AltName: Full=Solute carrier family 9 member 8;
GN Name=Slc9a8; Synonyms=Nhe8;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=15731506; DOI=10.1152/ajpgi.00552.2004;
RA Xu H., Chen R., Ghishan F.K.;
RT "Subcloning, localization, and expression of the rat intestinal sodium-
RT hydrogen exchanger isoform 8.";
RL Am. J. Physiol. 289:G36-G41(2005).
CC -!- FUNCTION: Involved in pH regulation to eliminate acids generated by
CC active metabolism or to counter adverse environmental conditions. Major
CC proton extruding system driven by the inward sodium ion chemical
CC gradient. Plays an important role in signal transduction (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Multi-
CC pass membrane protein {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Intestine. Shows an apical localization in
CC intestinal epithelial cells. {ECO:0000269|PubMed:15731506}.
CC -!- DEVELOPMENTAL STAGE: Expression is higher in 2 and 3 week old rats and
CC lower in adults. {ECO:0000269|PubMed:15731506}.
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 1 (CPA1)
CC transporter (TC 2.A.36) family. {ECO:0000305}.
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DR EMBL; AY496958; AAS75864.1; -; mRNA.
DR RefSeq; NP_001020452.1; NM_001025281.1.
DR AlphaFoldDB; Q4L208; -.
DR SMR; Q4L208; -.
DR STRING; 10116.ENSRNOP00000012175; -.
DR iPTMnet; Q4L208; -.
DR PhosphoSitePlus; Q4L208; -.
DR PaxDb; Q4L208; -.
DR GeneID; 311651; -.
DR KEGG; rno:311651; -.
DR CTD; 23315; -.
DR RGD; 1308193; Slc9a8.
DR eggNOG; KOG1965; Eukaryota.
DR InParanoid; Q4L208; -.
DR OrthoDB; 546232at2759; -.
DR PhylomeDB; Q4L208; -.
DR Reactome; R-RNO-425986; Sodium/Proton exchangers.
DR PRO; PR:Q4L208; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015386; F:potassium:proton antiporter activity; IBA:GO_Central.
DR GO; GO:0015385; F:sodium:proton antiporter activity; IBA:GO_Central.
DR GO; GO:0071805; P:potassium ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0051453; P:regulation of intracellular pH; IBA:GO_Central.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR018422; Cation/H_exchanger_CPA1.
DR InterPro; IPR004709; NaH_exchanger.
DR PANTHER; PTHR10110; PTHR10110; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR PRINTS; PR01084; NAHEXCHNGR.
DR TIGRFAMs; TIGR00840; b_cpa1; 1.
PE 2: Evidence at transcript level;
KW Antiport; Golgi apparatus; Ion transport; Membrane; Phosphoprotein;
KW Reference proteome; Sodium; Sodium transport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..575
FT /note="Sodium/hydrogen exchanger 8"
FT /id="PRO_0000379803"
FT TRANSMEM 54..74
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 78..98
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 117..137
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 150..170
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 185..205
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 255..275
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 305..325
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 348..368
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 373..393
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 411..431
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 445..465
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOD_RES 504
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q8R4D1"
FT MOD_RES 565
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9Y2E8"
FT MOD_RES 567
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9Y2E8"
SQ SEQUENCE 575 AA; 64609 MW; 57E85DEFB7122C2A CRC64;
MAEEFSNTTH ESFNFTLHTT LGVTTKLVLP TPAEPILPVQ TGEQAQQEEQ SSGMTIFFSL
LVLAICIILV HLLIRYRLHF LPESVAVVSL GILMGAVIKV IEFKKLANWK EEEMFRPNMF
FLLLLPPIIF ESGYSLHKGN FFQNIGSITL FAVFGTAISA FVVGGGIYFL GQADVISKLN
MTDSFAFGSL ISAVDPVATI AIFNALHVDP VLNMLVFGES ILNDAVSIVL TNTAEGLTRK
HMSDVSGWQT FSQALGYFLK MFFGSAALGT LTGLISALVL KHIDLRKTPS LEFGMMIIFA
YLPYGLAEGI SLSGIMAILF SGIVMSHYTH HNLSPVTQIL MQQTLRTVAF LCETCVFAFL
GLSIFSFPHK FEISFVIWCI VLVLFGRAVN IFPLSYLLNF FRDHKITPKM MFIMWFSGLR
GAIPYALSLH LGLEPMEKRQ LIGTTTIIIV LFTILLLGGS TMPLIRLVDI EDARARRRSK
KDVNLSKTEK MGNAIESEHL SELTEEEYEA HYIRQQDLKG FMWLDAKYLN PFFTRRLTQE
DLHHGRIQMK SLTNKWYEEV RQGPSGSEDD EQELF
