SL9B1_MACFA
ID SL9B1_MACFA Reviewed; 511 AA.
AC Q4R7S2; Q95JS4;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 2.
DT 03-AUG-2022, entry version 59.
DE RecName: Full=Sodium/hydrogen exchanger 9B1;
DE AltName: Full=Na(+)/H(+) exchanger-like domain-containing protein 1;
DE Short=NHE domain-containing protein 1;
DE AltName: Full=Sodium/hydrogen exchanger-like domain-containing protein 1;
DE AltName: Full=Solute carrier family 9 subfamily B member 1;
GN Name=SLC9B1; Synonyms=NHA1, NHEDC1; ORFNames=QtsA-13925, QtsA-14489;
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=12498619; DOI=10.1186/1471-2164-3-36;
RA Osada N., Hida M., Kusuda J., Tanuma R., Hirata M., Suto Y., Hirai M.,
RA Terao K., Sugano S., Hashimoto K.;
RT "Cynomolgus monkey testicular cDNAs for discovery of novel human genes in
RT the human genome sequence.";
RL BMC Genomics 3:36-36(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RG International consortium for macaque cDNA sequencing and analysis;
RT "DNA sequences of macaque genes expressed in brain or testis and its
RT evolutionary implications.";
RL Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Sperm-specific Na(+)/H(+) exchanger involved in intracellular
CC pH regulation of spermatozoa. Involved in sperm motility and fertility.
CC {ECO:0000250|UniProtKB:Q8C0X2}.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium, flagellum membrane
CC {ECO:0000250|UniProtKB:Q8C0X2}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 1 (CPA1)
CC transporter (TC 2.A.36) family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAE00850.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AB070105; BAB63050.1; -; mRNA.
DR EMBL; AB168740; BAE00850.1; ALT_INIT; mRNA.
DR RefSeq; NP_001306523.1; NM_001319594.1.
DR AlphaFoldDB; Q4R7S2; -.
DR SMR; Q4R7S2; -.
DR STRING; 9541.XP_005555617.1; -.
DR GeneID; 102142364; -.
DR CTD; 150159; -.
DR eggNOG; KOG3826; Eukaryota.
DR Proteomes; UP000233100; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0097228; C:sperm principal piece; ISS:UniProtKB.
DR GO; GO:0015299; F:solute:proton antiporter activity; IEA:InterPro.
DR GO; GO:0030317; P:flagellated sperm motility; ISS:UniProtKB.
DR GO; GO:0051453; P:regulation of intracellular pH; ISS:UniProtKB.
DR GO; GO:0007338; P:single fertilization; IEA:UniProtKB-KW.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1530.20; -; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR InterPro; IPR030187; SLC9B1.
DR PANTHER; PTHR31102:SF5; PTHR31102:SF5; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
PE 2: Evidence at transcript level;
KW Antiport; Cell membrane; Cell projection; Cilium; Fertilization; Flagellum;
KW Ion transport; Membrane; Reference proteome; Sodium; Sodium transport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..511
FT /note="Sodium/hydrogen exchanger 9B1"
FT /id="PRO_0000314008"
FT TRANSMEM 67..87
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 95..115
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 116..136
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 152..172
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 187..207
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 215..235
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 260..280
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 284..304
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 337..357
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 368..388
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 398..418
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 431..451
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 472..492
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 16..36
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 53
FT /note="K -> R (in Ref. 1; BAB63050)"
FT /evidence="ECO:0000305"
FT CONFLICT 103
FT /note="C -> Y (in Ref. 1; BAB63050)"
FT /evidence="ECO:0000305"
FT CONFLICT 286
FT /note="S -> P (in Ref. 1; BAB63050)"
FT /evidence="ECO:0000305"
FT CONFLICT 318
FT /note="E -> K (in Ref. 1; BAB63050)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 511 AA; 55445 MW; 92DE33C212AB4C22 CRC64;
MHTTESKDEH LEDENFQTST TPQSLIDPNS TAHEETKTVI SDTEEIKPQT KKKTYISCPL
RGALNRIITN GVILFVIWCT TWSVLGSEAL PGGNLFGLLI IFCSAIIGGK ILQLIRIPLV
PPLPPLLGML LAGFTIRNVP FISKHVHVHN TWSSILRSTA LTVILIRAGL GLDPQALRHL
KVVCFRLAVG PCLMEASAAA VFSHFIMKFP WEWAFLLGFV LGAVSPAIVV PSMMVLQENG
YGVEEGIPSL LMAASSMDDV LAITGFNTCL SIVFSSGGIV NNAIASIKSV SISLLAGIVL
GFFVRYFPSE DQKKLALERG FLILTMCVSA VLGSQRIGLH GTGGLFTLVL SFIAGTKWSQ
EKMKVQKIIT NVWDIFQPLL FGLVGAEVSV SLLESNTIGI FVATLSLALC VRILVTYILM
CFAGFSFKEK IFIALAWMPK ATVQAVLGPL VLETARVSAP HLEPYSKDVM TVAFLAILIT
APNGALLMGI LGPKLLRRHY DPSKIKLQLS T
