SL9B2_XENTR
ID SL9B2_XENTR Reviewed; 539 AA.
AC A4IHB9;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2007, sequence version 1.
DT 03-AUG-2022, entry version 72.
DE RecName: Full=Sodium/hydrogen exchanger 9B2;
DE AltName: Full=Na(+)/H(+) exchanger NHA2;
DE AltName: Full=Na(+)/H(+) exchanger-like domain-containing protein 2;
DE Short=NHE domain-containing protein 2;
DE AltName: Full=Sodium/hydrogen exchanger-like domain-containing protein 2;
DE AltName: Full=Solute carrier family 9 subfamily B member 2;
GN Name=slc9b2; Synonyms=nha2, nhedc2;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Na(+)/H(+) antiporter that extrudes Na(+) or Li(+) in
CC exchange for external protons across the membrane. Contributes to the
CC regulation of intracellular pH, sodium homeostasis, and cell volume (By
CC similarity). {ECO:0000250|UniProtKB:Q5BKR2}.
CC -!- SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:Q86UD5}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q5BKR2};
CC Multi-pass membrane protein {ECO:0000255}. Mitochondrion membrane
CC {ECO:0000250|UniProtKB:Q5BKR2}; Multi-pass membrane protein
CC {ECO:0000255}. Endosome membrane {ECO:0000250|UniProtKB:Q5BKR2}; Multi-
CC pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory
CC vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:Q5BKR2};
CC Multi-pass membrane protein {ECO:0000250|UniProtKB:Q5BKR2}.
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 1 (CPA1)
CC transporter (TC 2.A.36) family. {ECO:0000305}.
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DR EMBL; BC135456; AAI35457.1; -; mRNA.
DR RefSeq; NP_001093729.1; NM_001100259.1.
DR AlphaFoldDB; A4IHB9; -.
DR SMR; A4IHB9; -.
DR STRING; 8364.ENSXETP00000022480; -.
DR GeneID; 100101762; -.
DR KEGG; xtr:100101762; -.
DR CTD; 133308; -.
DR Xenbase; XB-GENE-478907; slc9b2.
DR eggNOG; KOG3826; Eukaryota.
DR InParanoid; A4IHB9; -.
DR OrthoDB; 833306at2759; -.
DR Reactome; R-XTR-2672351; Stimuli-sensing channels.
DR Proteomes; UP000008143; Chromosome 1.
DR Proteomes; UP000790000; Unplaced.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015385; F:sodium:proton antiporter activity; IEA:InterPro.
DR GO; GO:0030317; P:flagellated sperm motility; IEA:InterPro.
DR Gene3D; 1.20.1530.20; -; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR InterPro; IPR037072; SLC9B2.
DR PANTHER; PTHR31102:SF14; PTHR31102:SF14; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
PE 2: Evidence at transcript level;
KW Antiport; Cell membrane; Cytoplasmic vesicle; Endosome;
KW Hydrogen ion transport; Ion transport; Membrane; Mitochondrion;
KW Reference proteome; Sodium; Sodium transport; Synapse; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..539
FT /note="Sodium/hydrogen exchanger 9B2"
FT /id="PRO_0000331273"
FT TRANSMEM 92..112
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 123..143
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 144..164
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 180..200
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 233..253
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 274..294
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 315..335
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 349..369
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 373..393
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 396..416
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 433..453
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 498..518
FT /note="Helical"
FT /evidence="ECO:0000255"
FT SITE 286
FT /note="Important for cation transport"
FT /evidence="ECO:0000250"
FT SITE 287
FT /note="Important for cation transport"
FT /evidence="ECO:0000250"
SQ SEQUENCE 539 AA; 57148 MW; 53E7582EA2CA634C CRC64;
MEDSLFSVDK AGPGKDASAA SADCNHMVAE DGIITEQHKE IPLVALKVPD GHAPIDECEL
LNSDDQLPKG SQNQTNICMR IRAFACPPQG CFSLAITNVT MVILIWAVVW SITGPECLPG
GNLFGILALL FSAALGGKLI SLIKIPSLPP LPPLLGMLLA GFLIRNIPVI TDQVQIHHKW
SAALRNIALA IILVRAGLGL DPKALRKLKA VCLRLSFGPC VVESCTAAVV SHFIMGFPLT
WGFMLGFVLG AVSPAVVVPS MLILQKEGFG VDKGIPTLLM AAGSFDDVLA ITGFNTCLGM
AFSSGSTLNT IVRGVLEVVV GIAAGLLFGF FLHYFPSKDQ ENLKGKRSYL ILALSVFAVF
GSLYFGFPGS GGLCTLVMAF LAGIGWSTDK TVVEDIIAVS WDIFQPLLFG LIGAEISVAS
LKPETVGLCT ATLIIALIIR ICISFLMVCF SGFSLKEKIF ISLAWMPKAT VQAAIGSVAL
DTARTLENKQ FEDYGMDVLT VAFLGILVTA PIGALVIGLT GPKMLEKSES RTVTEEGSV
