ID   SLAA_ACIAM              Reviewed;        1016 AA.
AC   B1GT61;
DT   23-MAY-2018, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2008, sequence version 1.
DT   25-MAY-2022, entry version 11.
DE   RecName: Full=S-layer protein A {ECO:0000303|PubMed:19522740};
DE   AltName: Full=Surface layer large protein {ECO:0000305};
DE   Flags: Precursor;
GN   Name=slaA {ECO:0000303|PubMed:19522740};
OS   Acidianus ambivalens (Desulfurolobus ambivalens).
OC   Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC   Acidianus.
OX   NCBI_TaxID=2283;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 31-39, FUNCTION,
RP   SUBUNIT, SUBCELLULAR LOCATION, AND INDUCTION.
RC   STRAIN=Lei 10 / DSM 3772 / JCM 9191;
RX   PubMed=19522740; DOI=10.1111/j.1365-2958.2009.06746.x;
RA   Veith A., Klingl A., Zolghadr B., Lauber K., Mentele R., Lottspeich F.,
RA   Rachel R., Albers S.V., Kletzin A.;
RT   "Acidianus, Sulfolobus and Metallosphaera surface layers: structure,
RT   composition and gene expression.";
RL   Mol. Microbiol. 73:58-72(2009).
CC   -!- FUNCTION: S-layer large protein. May form the highly ordered outer
CC       sheath. {ECO:0000269|PubMed:19522740}.
CC   -!- SUBUNIT: The mushroom-shaped unit cells of the Sulfolobales' S-layers
CC       may consist of three SlaB subunits and six SlaA subunits.
CC       {ECO:0000305|PubMed:19522740}.
CC   -!- SUBCELLULAR LOCATION: Secreted, cell wall, S-layer
CC       {ECO:0000269|PubMed:19522740}.
CC   -!- INDUCTION: Constitutively expressed. The level of slaA transcription is
CC       much higher than slaB. {ECO:0000269|PubMed:19522740}.
CC   -!- SIMILARITY: Belongs to the Sulfolobales SlaA family. {ECO:0000305}.
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DR   EMBL; AM690769; CAM84437.1; -; Genomic_DNA.
DR   AlphaFoldDB; B1GT61; -.
DR   SMR; B1GT61; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0030115; C:S-layer; IEA:UniProtKB-SubCell.
PE   1: Evidence at protein level;
KW   Cell wall; Direct protein sequencing; S-layer; Secreted; Signal.
FT   SIGNAL          1..30
FT                   /evidence="ECO:0000269|PubMed:19522740"
FT   CHAIN           31..1016
FT                   /note="S-layer protein A"
FT                   /id="PRO_0000444049"
SQ   SEQUENCE   1016 AA;  112334 MW;  BEABFD41A52D0D5C CRC64;
     MDLSTKKVIS AGLVFIYALS LAMLVPMFLA SNQGVISAVI NPATGGNCLP GRYSGIVQAS
     GVTLPAVNLS YVAPFTSALP LLVYSQSIFN GTLYYYNSTG SYELMKKYGI SITPVHQIVN
     VTSRFFARTT EGVIPNTLPP YTSGNCYLFN TTPPTPFYYS YRTLAMVNSY FPNTQYINTS
     SEISDLYFNV SYLPYNTTLT LSIYATPALQ GIEGIIRFNF SVKLCANSTI YPYAEYTLHA
     YFYFNNSFIC ELENIKTSIP GVASATSPTT IHFTSTAVNY ILLVDLGLWS NVSTVYVTGV
     EGATYPSDTV ATTINNGSFH PVIIPPAICI QYKTFYSNQI NPELPNTSGP DSIPYMIANV
     TIYSPDDMLN WTYAQKYVGC IAAEYANPKW NPYCKINEAW YNNYGHGGNG LTVTLMVGNN
     KVLSINYPYL ALCHVSYTDG FHNFVYKFSI EFLLSSVDNI TYMLTTVAPN STGLGGDMLY
     VLIKPCQLKD ATILLTYNDS DYAVQHYFGP VDREIAVVCN NIKVYTPLLY MPKCVPISTP
     FFYGQVIDYD YGYNYALVGY VNTYYFNATS HQYYKVGQYV DVQHVSGDSE LVLGVCPGYK
     CASLSIYYPN TPPYYPASHE AKVGKIMGIC IEFANGTMER IYLSPSNITA LLTTNVMKQM
     APMPPFWNYS FEISITGLES ILHITPNQAL TVLNNSYIIV CYYDIASNST VHNMTKLVST
     PVTVAISPPS QAFYYAPATP FDDIVHPGCQ IFYFVNVNAT YPITVTLTDK SLGELSPTTI
     VTTTVTCIYV ILYNGTMLHY NSAVFPITLT ETAPSSGVFT ATLYVEVTNS KGTPVTAYPL
     NYSYIAIYNP ATKMQIIVGK LSNIMPLVPS KYFKVGVVVD GLSANSTFTL TEIPNVIYNV
     SPIIYNYIDG ELSVTVAANI PGYYYSGYLV LTIYNCTAKP CHPIYTYEIY FNFSATSPHF
     VAAYDLLFLE PILNGHTYYI TITAIVVPLT YEPFTTIGFE GKVFSGAYFF SAPAGS