ID   SLAA_METS5              Reviewed;        1360 AA.
AC   A4YHQ8;
DT   23-MAY-2018, integrated into UniProtKB/Swiss-Prot.
DT   29-MAY-2007, sequence version 1.
DT   25-MAY-2022, entry version 53.
DE   RecName: Full=S-layer protein A {ECO:0000303|PubMed:19522740};
DE   AltName: Full=Surface layer large protein {ECO:0000305};
DE   Flags: Precursor;
GN   Name=slaA {ECO:0000303|PubMed:19522740};
GN   OrderedLocusNames=Msed_1806 {ECO:0000312|EMBL:ABP95960.1};
OS   Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509
OS   / TH2).
OC   Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC   Metallosphaera.
OX   NCBI_TaxID=399549;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2;
RX   PubMed=18083856; DOI=10.1128/aem.02019-07;
RA   Auernik K.S., Maezato Y., Blum P.H., Kelly R.M.;
RT   "The genome sequence of the metal-mobilizing, extremely thermoacidophilic
RT   archaeon Metallosphaera sedula provides insights into bioleaching-
RT   associated metabolism.";
RL   Appl. Environ. Microbiol. 74:682-692(2008).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY, FUNCTION, SUBUNIT, AND SUBCELLULAR
RP   LOCATION.
RX   PubMed=19522740; DOI=10.1111/j.1365-2958.2009.06746.x;
RA   Veith A., Klingl A., Zolghadr B., Lauber K., Mentele R., Lottspeich F.,
RA   Rachel R., Albers S.V., Kletzin A.;
RT   "Acidianus, Sulfolobus and Metallosphaera surface layers: structure,
RT   composition and gene expression.";
RL   Mol. Microbiol. 73:58-72(2009).
CC   -!- FUNCTION: S-layer large protein. May form the highly ordered outer
CC       sheath. {ECO:0000269|PubMed:19522740}.
CC   -!- SUBUNIT: The mushroom-shaped unit cells of the Sulfolobales' S-layers
CC       may consist of three SlaB subunits and six SlaA subunits.
CC       {ECO:0000305|PubMed:19522740}.
CC   -!- SUBCELLULAR LOCATION: Secreted, cell wall, S-layer
CC       {ECO:0000269|PubMed:19522740}.
CC   -!- SIMILARITY: Belongs to the Sulfolobales SlaA family. {ECO:0000305}.
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DR   EMBL; CP000682; ABP95960.1; -; Genomic_DNA.
DR   RefSeq; WP_012021747.1; NC_009440.1.
DR   AlphaFoldDB; A4YHQ8; -.
DR   STRING; 399549.Msed_1806; -.
DR   EnsemblBacteria; ABP95960; ABP95960; Msed_1806.
DR   GeneID; 5105369; -.
DR   KEGG; mse:Msed_1806; -.
DR   eggNOG; arCOG08800; Archaea.
DR   HOGENOM; CLU_257028_0_0_2; -.
DR   OMA; FWFFITM; -.
DR   Proteomes; UP000000242; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0030115; C:S-layer; IEA:UniProtKB-SubCell.
PE   1: Evidence at protein level;
KW   Cell wall; Reference proteome; S-layer; Secreted; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..1360
FT                   /note="S-layer protein A"
FT                   /id="PRO_0000444050"
SQ   SEQUENCE   1360 AA;  143557 MW;  D8907A8808A3ECF4 CRC64;
     MNKSAIRYLS LLLVFLMGGS FLAGITTFGQ TSSTAGGVTI SVSNEWVGND TVVLVAIYNP
     NVPQSAQGAK YVAGNVTISA GGVTVPLISN DTSNASVVYY LNNGQHYFWF FITMTPVPTT
     SASSLSMTET LTINSTSTNV QLTNPYLSFT TPVGNVQTDG KAGVFQLTLP SSFPNQLIGE
     YGQTVYGGHK VNITDLYFFS GDKTITISYS TGASVTINNY LADSSNYAAT LQTTESTVPL
     NSTWQVYFVD NIMQANPLVG GNGGFMITAN GTQVSPVIQN VSYLAVKNGV YVNTTVFANN
     PVPNAQAMFG YGNVYYGNFT MYTSSIVTNK TYATLLSGNN YTPANVSFSQ YKMLITSGLF
     TTNTPITIYL SDWIGNNASV SIKGTIKETT LQSITLSVQK GENLTVNDFN NISNYSVRRN
     IMVYVALQNI TGSTYKTAMV SLPETYAGSG VFSLPTVLRI GSSPSITYST SQVTITLPPY
     DFSNTSLLIT ATNDIGASYY YLGSNTVKNI STPGTISVGT PTLVPIPNVV SVANVTPVIE
     LAYTEPNLAF GTATTLTVSG TSVKYNGVQV ATDSVTAVLP NGTVISGNLN GLSITSLTSA
     NGNGTFFIVV PSTVIKTFLG THTYIPSGTE LTFKIYDEFA AQTLSVTYKF TTVAPVIAIK
     TPTSTSFSSA ETAYLPPLPY NVVPEKHYIS VNVTDTLYAQ SVPSSALQTT LKIIVENPAG
     QKVGNVVTTV VSETAANSGL FTGKIYYTVY ENSSGYWLNI NGQNITNLKN VVNGGLIVFE
     YTSPSSQSTV NATALLEPSP FTLSVSQTSA NPGQHVNVSV NSPGLVESSN MKFTGSLIIY
     AQFAEWNGPG SQPTIAVSPI TLKEVSAGSP VFGGTIVLGN SSVVSSGNLT SLITTPGYTV
     APGSVVLVNA NATIGPTSTS SSITPYYQQQ SISINVVDIN VSILNPSPAS PFAKLEIELQ
     SPLFNLLTHP AAGNYTSAGT SAGILEGILS TITTQQSQQL VTSTQLVTSP KTSFYYNNTI
     WVIETPMTLW SGTPGSYGIP IEVNLTDLLT VTHNVYAIHV VEVPNVTTGT VSLVSAYAVP
     SVSSNVAQLQ INGLVPPVIS VFFNGNNITQ SASAAIPFPN TTAGELVNVT VYAPDAVNNL
     NVPGSGTTFN VTIVNTANGE TTTLTLTQMT KIIGGVAVPT PYYTGLLKVV EPTVYTPGTP
     GVISASSGVV NKVLVNMNLV EGQYYNTQGL LQQLRMKASS YFYVGVIKLS VLVSHFTILS
     NGTPVTGMQV GKSYSLLFNV TNNGNVNETI YGTLEVLLNG TPVQPEIVAQ ITLAPGQSTQ
     IGTLFTPTMP GSYTITFIPF QNNLLSIPYN QGLTEVVTAS