ID   SLAA_SACS2              Reviewed;        1231 AA.
AC   Q980C7; Q2M1E7;
DT   23-MAY-2018, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2001, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=S-layer protein A {ECO:0000303|PubMed:19522740};
DE   AltName: Full=Surface layer large protein {ECO:0000305};
DE   Flags: Precursor;
GN   Name=slaA {ECO:0000303|PubMed:19522740};
GN   Synonyms=slp1 {ECO:0000312|EMBL:CAJ31324.1};
GN   OrderedLocusNames=SSO0389 {ECO:0000312|EMBL:AAK40716.1};
OS   Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
OS   (Sulfolobus solfataricus).
OC   Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC   Saccharolobus.
OX   NCBI_TaxID=273057;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 35092 / DSM 1617 / JCM 11322 / P2;
RX   PubMed=16391651; DOI=10.1139/w05-093;
RA   Claus H., Akca E., Debaerdemaeker T., Evrard C., Declercq J.P.,
RA   Harris J.R., Schlott B., Konig H.;
RT   "Molecular organization of selected prokaryotic S-layer proteins.";
RL   Can. J. Microbiol. 51:731-743(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35092 / DSM 1617 / JCM 11322 / P2;
RX   PubMed=11427726; DOI=10.1073/pnas.141222098;
RA   She Q., Singh R.K., Confalonieri F., Zivanovic Y., Allard G., Awayez M.J.,
RA   Chan-Weiher C.C.-Y., Clausen I.G., Curtis B.A., De Moors A., Erauso G.,
RA   Fletcher C., Gordon P.M.K., Heikamp-de Jong I., Jeffries A.C., Kozera C.J.,
RA   Medina N., Peng X., Thi-Ngoc H.P., Redder P., Schenk M.E., Theriault C.,
RA   Tolstrup N., Charlebois R.L., Doolittle W.F., Duguet M., Gaasterland T.,
RA   Garrett R.A., Ragan M.A., Sensen C.W., Van der Oost J.;
RT   "The complete genome of the crenarchaeon Sulfolobus solfataricus P2.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:7835-7840(2001).
RN   [3]
RP   PROTEIN SEQUENCE OF 36-41, FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, AND
RP   INDUCTION.
RC   STRAIN=ATCC 35092 / DSM 1617 / JCM 11322 / P2;
RX   PubMed=19522740; DOI=10.1111/j.1365-2958.2009.06746.x;
RA   Veith A., Klingl A., Zolghadr B., Lauber K., Mentele R., Lottspeich F.,
RA   Rachel R., Albers S.V., Kletzin A.;
RT   "Acidianus, Sulfolobus and Metallosphaera surface layers: structure,
RT   composition and gene expression.";
RL   Mol. Microbiol. 73:58-72(2009).
CC   -!- FUNCTION: S-layer large protein. May form the highly ordered outer
CC       sheath. {ECO:0000269|PubMed:19522740}.
CC   -!- SUBUNIT: The mushroom-shaped unit cells of the Sulfolobales' S-layers
CC       may consist of three SlaB subunits and six SlaA subunits.
CC       {ECO:0000305|PubMed:19522740}.
CC   -!- SUBCELLULAR LOCATION: Secreted, cell wall, S-layer
CC       {ECO:0000269|PubMed:19522740}.
CC   -!- INDUCTION: Constitutively expressed. {ECO:0000269|PubMed:19522740}.
CC   -!- SIMILARITY: Belongs to the Sulfolobales SlaA family. {ECO:0000305}.
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DR   EMBL; BN000829; CAJ31324.1; -; Genomic_DNA.
DR   EMBL; AE006641; AAK40716.1; -; Genomic_DNA.
DR   PIR; E90182; E90182.
DR   RefSeq; WP_010922960.1; NC_002754.1.
DR   AlphaFoldDB; Q980C7; -.
DR   IntAct; Q980C7; 1.
DR   MINT; Q980C7; -.
DR   STRING; 273057.SSO0389; -.
DR   EnsemblBacteria; AAK40716; AAK40716; SSO0389.
DR   GeneID; 27426684; -.
DR   KEGG; sso:SSO0389; -.
DR   PATRIC; fig|273057.12.peg.383; -.
DR   eggNOG; arCOG06039; Archaea.
DR   HOGENOM; CLU_264979_0_0_2; -.
DR   OMA; VEWILTA; -.
DR   Proteomes; UP000001974; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0030115; C:S-layer; IEA:UniProtKB-SubCell.
PE   1: Evidence at protein level;
KW   Cell wall; Direct protein sequencing; Reference proteome; S-layer;
KW   Secreted; Signal.
FT   SIGNAL          1..35
FT                   /evidence="ECO:0000269|PubMed:19522740"
FT   CHAIN           36..1231
FT                   /note="S-layer protein A"
FT                   /id="PRO_0000444052"
SQ   SEQUENCE   1231 AA;  131868 MW;  B85623012F8BCAEE CRC64;
     MNKTLGLILT SVFLLSTLGI ITGFVIPTQA ANSNDAAIYT IPSVTSVSNT SNIVINLFFN
     ATSNSTVGAQ ASAFNYGLAI NYTLDAITFT VVLPSGTSYP LIKLNAKNFA NYGYYDLAHN
     SIVLLLNTTA SSTAKELAYS YEQSIGVTPS ASYKIYNYTN KTVNVNQYMN ELPLSMLIYM
     ATNGKYNNLA SLPVGTKLEF TYAGVTYIIA VSPTVKLVGE LLNPLYTANS KMLPGTNYAV
     GRSNITVAVY DNLITTTTSP FNFTLTYSSL APALIYWFVI ANTTYTNNGA STPTASFQAP
     PFKQYFPSNS TILYSAAPTK SSILMFNGQM NVTAHENVTL TLQTGTNIYT SPNFNVTPPG
     NYTFSGKLGV GFNGFIYQNG SATLTATIFN GTINFFFSST GQKAAFTFFL VPIVPINLGD
     NNGATVIYNG VSLNTGFPQV VVMFNITGNF TKSGSNYLLY GSVYEAELKP LGSTQLQKLA
     GATDSTQFVG NLISSASSPL VSYFNYGEST TTITGTSLSF TVLMPLKFIV ERLGYIYLVT
     FHIWGPSATV TVTGVDYHGT QIALGSFRAY VALPSFYTLP KTPLVGLTCD NMYTLAQVSD
     AGSVLETSTA NSNANNATVI GPYDLMSNAG LHVAIYNGSK LVKSGNLGLL PNATTAPITT
     TITLNGQTVA LTYSSAPTAI YPVDFKFEPG FSYSVTTNVI YNTSIPTYVV TVYMPLKYIL
     QTKIVMWYVS PDYAAYFYYS STGQYQTSNV TLTFANVTPE LVMPQVFPVG KLYMPFGIND
     PYYVFYSSIS IGPQSGVIEA VENGFNVGNI TSITVELNGM NESIVLSPLN VSKLLISSNL
     GEVSQCSPLF TTTLFNISAL ASLLGLPNAA ALNGSYLYVT YHDIISGAYV TNRTLLVVGQ
     FYVMPPTTPG SVEWILTAKY INATTGIPVE ISYAVVQQPS AKVVDINAAN ASITQIQVTG
     VKIVSKYATV TVMYNPSNAS TIVYMNGMFV ASYGGNLISS LSETSTFGVY YGAVVNLYVA
     TGTLSSPNGT MYVVLGSHKV AVGTANLYTY AGYHFGPYTA LPLVSNVTFT VQDPVTHATL
     TGQTTLGAFN NTPIRLAPLG VSIPQTAQYK VFYYYSTPLV LSPTSQYIVL SVTSVISYPY
     PFYIETVSFL GYNVTTGTPV PGTPAFQTVY SPSLGPGVVL QVPVQSYQFI SLSTPSEPHT
     VVMFAVPFAG GPAISLYPTF LVYANVTAIS S