SLAA_SULAC
ID SLAA_SULAC Reviewed; 1424 AA.
AC Q4J6E5; Q2M1E8;
DT 23-MAY-2018, integrated into UniProtKB/Swiss-Prot.
DT 02-AUG-2005, sequence version 1.
DT 25-MAY-2022, entry version 55.
DE RecName: Full=S-layer protein A {ECO:0000305};
DE AltName: Full=Surface layer large protein {ECO:0000305};
DE Flags: Precursor;
GN Name=slaA {ECO:0000303|PubMed:20936123};
GN Synonyms=slp1 {ECO:0000312|EMBL:CAJ30479.1};
GN OrderedLocusNames=Saci_2355 {ECO:0000312|EMBL:AAY81636.1};
OS Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC
OS 15157 / NCIMB 11770).
OC Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC Sulfolobus.
OX NCBI_TaxID=330779;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770;
RX PubMed=16391651; DOI=10.1139/w05-093;
RA Claus H., Akca E., Debaerdemaeker T., Evrard C., Declercq J.P.,
RA Harris J.R., Schlott B., Konig H.;
RT "Molecular organization of selected prokaryotic S-layer proteins.";
RL Can. J. Microbiol. 51:731-743(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770;
RX PubMed=15995215; DOI=10.1128/jb.187.14.4992-4999.2005;
RA Chen L., Bruegger K., Skovgaard M., Redder P., She Q., Torarinsson E.,
RA Greve B., Awayez M., Zibat A., Klenk H.-P., Garrett R.A.;
RT "The genome of Sulfolobus acidocaldarius, a model organism of the
RT Crenarchaeota.";
RL J. Bacteriol. 187:4992-4999(2005).
RN [3]
RP SUBCELLULAR LOCATION, AND GLYCOSYLATION AT ASN-1042; ASN-1093; ASN-1134;
RP ASN-1197; ASN-1217; ASN-1252; ASN-1276; ASN-1304 AND ASN-1419.
RC STRAIN=ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770;
RX PubMed=20936123; DOI=10.1155/2010/754101;
RA Peyfoon E., Meyer B., Hitchen P.G., Panico M., Morris H.R., Haslam S.M.,
RA Albers S.V., Dell A.;
RT "The S-layer glycoprotein of the crenarchaeote Sulfolobus acidocaldarius is
RT glycosylated at multiple sites with chitobiose-linked N-glycans.";
RL Archaea 2010:754101-754101(2010).
CC -!- FUNCTION: S-layer large protein. May form the highly ordered outer
CC sheath. {ECO:0000250|UniProtKB:Q980C7}.
CC -!- SUBUNIT: The mushroom-shaped unit cells of the Sulfolobales' S-layers
CC may consist of three SlaB subunits and six SlaA subunits.
CC {ECO:0000250|UniProtKB:Q980C7}.
CC -!- SUBCELLULAR LOCATION: Secreted, cell wall, S-layer
CC {ECO:0000269|PubMed:20936123}.
CC -!- PTM: Glycosylated. C-terminal glycosylation sites are modified with a
CC heterogeneous family of glycans, with the largest having a composition
CC Glc(1)Man(2)GlcNAc(2) plus 6-sulfoquinovose (QuiS).
CC {ECO:0000269|PubMed:20936123}.
CC -!- SIMILARITY: Belongs to the Sulfolobales SlaA family. {ECO:0000305}.
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DR EMBL; CP000077; AAY81636.1; -; Genomic_DNA.
DR EMBL; BN000824; CAJ30479.1; -; Genomic_DNA.
DR RefSeq; WP_011279138.1; NC_007181.1.
DR AlphaFoldDB; Q4J6E5; -.
DR iPTMnet; Q4J6E5; -.
DR EnsemblBacteria; AAY81636; AAY81636; Saci_2355.
DR GeneID; 3472789; -.
DR KEGG; sai:Saci_2355; -.
DR PATRIC; fig|330779.12.peg.2362; -.
DR eggNOG; arCOG06039; Archaea.
DR HOGENOM; CLU_264979_0_0_2; -.
DR OMA; TFQLNYS; -.
DR Proteomes; UP000001018; Chromosome.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0030115; C:S-layer; IEA:UniProtKB-SubCell.
PE 1: Evidence at protein level;
KW Cell wall; Glycoprotein; Reference proteome; S-layer; Secreted; Signal.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..1424
FT /note="S-layer protein A"
FT /id="PRO_0000444051"
FT CARBOHYD 60
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 70
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 276
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 295
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 342
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 358
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 377
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 468
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 517
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 545
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 559
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 581
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 633
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 714
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 875
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 914
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 955
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 989
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 1018
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 1042
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498,
FT ECO:0000269|PubMed:20936123"
FT CARBOHYD 1093
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498,
FT ECO:0000269|PubMed:20936123"
FT CARBOHYD 1134
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498,
FT ECO:0000269|PubMed:20936123"
FT CARBOHYD 1197
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498,
FT ECO:0000269|PubMed:20936123"
FT CARBOHYD 1217
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498,
FT ECO:0000269|PubMed:20936123"
FT CARBOHYD 1252
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498,
FT ECO:0000269|PubMed:20936123"
FT CARBOHYD 1276
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:20936123"
FT CARBOHYD 1304
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498,
FT ECO:0000269|PubMed:20936123"
FT CARBOHYD 1419
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498,
FT ECO:0000269|PubMed:20936123"
SQ SEQUENCE 1424 AA; 151040 MW; ED42E8245C112BDF CRC64;
MNKLVGLLVS SLFLASILIG IAPAITTTAL TPPVSAGGIQ AYLLTGSGAP ASGLVLFVVN
VSNIQVSSSN VTNVISTVVS NIQINAKTEN AQTGATTGSV TVRFPTSGYN AYYDSVDKVV
FVVVSFLYPY TTTSVNIPLS YLSKYLPGLL TAQPYDETGA QVTSVSSTPF GSLIDTSTGQ
QILGTNPVLT SYNSYTTQAN TNMQEGVVSG TLTSFTLGGQ SFSGSTVPVI LYAPFIFSNS
PYQAGLYNPM QVNGNLGSLS SEAYYHPVIW GRALINTTLI DTYASGSVPF TFQLNYSVPG
PLTINMAQLA WIASINNLPT SFTYLSYKFS NGYESFLGII SNSTQLTAGA LTINPSGNFT
INGKKFYVYL LVVGSTNSTT PVEYVTKLVV EYPSSTNFLP QGVTVTTSSN KYTLPVYEIG
GPAGTTITLT GNWYSTPYTV QITVGSTPTL TNYVSQILLK AVAYEGINVS TTQSPYYSTA
ILSTPPSEIS ITGSSTITAQ GKLTATSASA TVNLLTNATL TYENIPLTQY SFNGIIVTPG
YAAINGTTAM AYVIGALYNK TSDYVLSFAG SQEPMQVMNN NLTEVTTLAP FGLTLLAPSV
PATETGTSPL QLEFFTVPST SYIALVDFGL WGNLTSVTVS AYDTVNNKLS VNLGYFYGIV
IPPSISTAPY NYQNFICPNN YVTVTIYDPD AVLDPYPSGS FTTSSLPLKY GNMNITGAVI
FPGSSVYNPS GVFGYSNFNK GAAVTTFTYT AQSGPFSPVA LTGNTNYLSQ YADNNPTDNY
YFIQTVNGMP VLMGGLSIVA SPVSASLPSS TSSPGFMYLL PSAAQVPSPL PGMATPNYNL
NIYITYKIDG ATVGNNMING LYVASQNTLI YVVPNGSFVG SNIKLTYTTT DYAVLHYFYS
TGQYKVFKTV SVPNVTANLY FPSSTTPLYQ LSVPLYLSEP YYGSPLPTYI GLGTNGTSLW
NSPNYVLFGV SAVQQYLGFI KSISVTLSNG TTVVIPLTTS NMQTLFPQLV GQELQACNGT
FQFGISITGL EKLLNLNVQQ LNNSILSVTY HDYVTGETLT ATTKLVALST LSLVAKGAGV
VEFLLTAYPY TGNITFAPPW FIAENVVKQP FMTYSDLQFA KTNPSAILSL STVNITVVGL
GGKASVYYNS TSGQTVITNI YGQTVATLSG NVLPTLTELA AGNGTFTGSL QFTIVPNNTV
VQIPSSLTKT SFAVYTNGSL AIVLNGKAYS LGPAGLFLLP FVTYTGSAIG ANATAIITVS
DGVGTSTTQV PITAENFTPI RLAPFQVPAQ VPLPNAPKLK YEYNGSIVIT PQQQVLKIYV
TSILPYPQEF QIQAFVYEAS QFNVHTGSPT AAPVYFSYSA VRAYPALGIG TSVPNLLVYV
QLQGISNLPA GKYVIVLSAV PFAGGPVLSE YPAQLIFTNV TLTQ
