SLAF9_HUMAN
ID SLAF9_HUMAN Reviewed; 289 AA.
AC Q96A28; Q5JRQ9; Q5JRR0; Q6UWG1;
DT 11-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT 02-NOV-2010, sequence version 2.
DT 03-AUG-2022, entry version 155.
DE RecName: Full=SLAM family member 9;
DE AltName: Full=CD2 family member 10;
DE Short=CD2F-10;
DE AltName: Full=CD84 homolog 1;
DE Short=CD84-H1;
DE Flags: Precursor;
GN Name=SLAMF9; Synonyms=CD2F10; ORFNames=UNQ1938/PRO4421;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, AND
RP VARIANT LEU-127.
RX PubMed=11300479;
RA Zhang W., Wan T., Li N., Yuan Z., He L., Zhu X., Yu M., Cao X.;
RT "Genetic approach to insight into the immunobiology of human dendritic
RT cells and identification of CD84-H1, a novel CD84 homologue.";
RL Clin. Cancer Res. Suppl. 7:822-829(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, AND VARIANT
RP LEU-127.
RX PubMed=11685473; DOI=10.1007/s002510100364;
RA Fennelly J.A., Tiwari B., Davis S.J., Evans E.J.;
RT "CD2F-10: a new member of the CD2 subset of the immunoglobulin
RT superfamily.";
RL Immunogenetics 53:599-602(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANT LEU-127.
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT LEU-127.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May play a role in the immune response.
CC {ECO:0000269|PubMed:11300479}.
CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q96A28-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96A28-2; Sequence=VSP_015819, VSP_015820;
CC -!- TISSUE SPECIFICITY: Expression is predominantly restricted in
CC hematopoietic tissues. Expressed in heart, spleen, liver, intestine,
CC muscle and testis. Expressed in immune cells, including monocytes,
CC dendritic, B- and T-cells. No expression was seen in peripheral blood
CC leukocytes. Expressed in the leukocyte cell line THP-1.
CC {ECO:0000269|PubMed:11300479, ECO:0000269|PubMed:11685473}.
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DR EMBL; AF275725; AAK69052.1; -; mRNA.
DR EMBL; AY034613; AAK61389.1; -; mRNA.
DR EMBL; AY358801; AAQ89161.1; -; mRNA.
DR EMBL; AL513485; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC074754; AAH74754.1; -; mRNA.
DR CCDS; CCDS1191.1; -. [Q96A28-1]
DR CCDS; CCDS53392.1; -. [Q96A28-2]
DR RefSeq; NP_001139644.1; NM_001146172.1. [Q96A28-2]
DR RefSeq; NP_001139645.1; NM_001146173.1.
DR RefSeq; NP_254273.2; NM_033438.3. [Q96A28-1]
DR AlphaFoldDB; Q96A28; -.
DR SMR; Q96A28; -.
DR BioGRID; 124637; 132.
DR STRING; 9606.ENSP00000357072; -.
DR GlyGen; Q96A28; 2 sites.
DR BioMuta; SLAMF9; -.
DR DMDM; 311033512; -.
DR PaxDb; Q96A28; -.
DR PeptideAtlas; Q96A28; -.
DR PRIDE; Q96A28; -.
DR Antibodypedia; 47060; 140 antibodies from 25 providers.
DR DNASU; 89886; -.
DR Ensembl; ENST00000368092.7; ENSP00000357071.3; ENSG00000162723.10. [Q96A28-2]
DR Ensembl; ENST00000368093.4; ENSP00000357072.3; ENSG00000162723.10. [Q96A28-1]
DR GeneID; 89886; -.
DR KEGG; hsa:89886; -.
DR MANE-Select; ENST00000368093.4; ENSP00000357072.3; NM_033438.4; NP_254273.2.
DR UCSC; uc001fus.3; human. [Q96A28-1]
DR CTD; 89886; -.
DR DisGeNET; 89886; -.
DR GeneCards; SLAMF9; -.
DR HGNC; HGNC:18430; SLAMF9.
DR HPA; ENSG00000162723; Not detected.
DR MIM; 608589; gene.
DR neXtProt; NX_Q96A28; -.
DR OpenTargets; ENSG00000162723; -.
DR PharmGKB; PA134993219; -.
DR VEuPathDB; HostDB:ENSG00000162723; -.
DR eggNOG; ENOG502SB7W; Eukaryota.
DR GeneTree; ENSGT01030000234540; -.
DR HOGENOM; CLU_069386_3_1_1; -.
DR InParanoid; Q96A28; -.
DR OMA; YNLHVYR; -.
DR OrthoDB; 990343at2759; -.
DR PhylomeDB; Q96A28; -.
DR TreeFam; TF334964; -.
DR PathwayCommons; Q96A28; -.
DR BioGRID-ORCS; 89886; 10 hits in 1063 CRISPR screens.
DR ChiTaRS; SLAMF9; human.
DR GenomeRNAi; 89886; -.
DR Pharos; Q96A28; Tbio.
DR PRO; PR:Q96A28; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q96A28; protein.
DR Bgee; ENSG00000162723; Expressed in amniotic fluid and 95 other tissues.
DR Genevisible; Q96A28; HS.
DR GO; GO:0009986; C:cell surface; IDA:MGI.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0042110; P:T cell activation; IBA:GO_Central.
DR Gene3D; 2.60.40.10; -; 2.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR SUPFAM; SSF48726; SSF48726; 2.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Disulfide bond; Glycoprotein; Immunoglobulin domain;
KW Membrane; Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..289
FT /note="SLAM family member 9"
FT /id="PRO_0000042233"
FT TOPO_DOM 19..236
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 237..257
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 258..289
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 27..114
FT /note="Ig-like V-type"
FT DOMAIN 136..210
FT /note="Ig-like C2-type"
FT CARBOHYD 99
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 208
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 156..200
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT VAR_SEQ 131
FT /note="R -> H (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12975309"
FT /id="VSP_015819"
FT VAR_SEQ 132..222
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12975309"
FT /id="VSP_015820"
FT VARIANT 86
FT /note="V -> M (in dbSNP:rs34540580)"
FT /id="VAR_032812"
FT VARIANT 127
FT /note="I -> L (in dbSNP:rs2789417)"
FT /evidence="ECO:0000269|PubMed:11300479,
FT ECO:0000269|PubMed:11685473, ECO:0000269|PubMed:12975309,
FT ECO:0000269|PubMed:15489334"
FT /id="VAR_023580"
FT VARIANT 164
FT /note="D -> H (in dbSNP:rs35438196)"
FT /id="VAR_032813"
FT VARIANT 181
FT /note="E -> K (in dbSNP:rs34884993)"
FT /id="VAR_032814"
SQ SEQUENCE 289 AA; 32436 MW; 2BA22CBAC2E7F275 CRC64;
MCAFPWLLLL LLLQEGSQRR LWRWCGSEEV VAVLQESISL PLEIPPDEEV ENIIWSSHKS
LATVVPGKEG HPATIMVTNP HYQGQVSFLD PSYSLHISNL SWEDSGLYQA QVNLRTSQIS
TMQQYNICVY RWLSEPQITV NFESSGEGAC SMSLVCSVEK AGMDMTYSWL SRGDSTYTFH
EGPVLSTSWR PGDSALSYTC RANNPISNVS SCPIPDGPFY ADPNYASEKP STAFCLLAKG
LLIFLLLVIL AMGLWVIRVQ KRHKMPRMKK LMRNRMKLRK EAKPGSSPA
