SLAF9_MOUSE
ID SLAF9_MOUSE Reviewed; 285 AA.
AC Q9D780; Q8BTK0; Q8VE93;
DT 11-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 2.
DT 25-MAY-2022, entry version 129.
DE RecName: Full=SLAM family member 9;
DE Flags: Precursor;
GN Name=Slamf9;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=B-cell, and Tongue;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May play a role in the immune response. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
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DR EMBL; AK009505; BAB26328.1; -; mRNA.
DR EMBL; AK090041; BAC41061.1; -; mRNA.
DR EMBL; BC019477; AAH19477.1; -; mRNA.
DR CCDS; CCDS15514.1; -.
DR RefSeq; NP_083888.3; NM_029612.4.
DR RefSeq; XP_017168527.1; XM_017313038.1.
DR AlphaFoldDB; Q9D780; -.
DR SMR; Q9D780; -.
DR STRING; 10090.ENSMUSP00000027830; -.
DR GlyGen; Q9D780; 6 sites.
DR PaxDb; Q9D780; -.
DR PRIDE; Q9D780; -.
DR ProteomicsDB; 261416; -.
DR ABCD; Q9D780; 22 sequenced antibodies.
DR DNASU; 98365; -.
DR GeneID; 98365; -.
DR KEGG; mmu:98365; -.
DR UCSC; uc007dql.2; mouse.
DR CTD; 89886; -.
DR MGI; MGI:1923692; Slamf9.
DR eggNOG; ENOG502SB7W; Eukaryota.
DR InParanoid; Q9D780; -.
DR OrthoDB; 990343at2759; -.
DR PhylomeDB; Q9D780; -.
DR TreeFam; TF334964; -.
DR BioGRID-ORCS; 98365; 1 hit in 73 CRISPR screens.
DR PRO; PR:Q9D780; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q9D780; protein.
DR GO; GO:0009986; C:cell surface; IDA:MGI.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0042742; P:defense response to bacterium; IMP:MGI.
DR GO; GO:0002410; P:plasmacytoid dendritic cell chemotaxis; IMP:MGI.
DR GO; GO:0002273; P:plasmacytoid dendritic cell differentiation; IMP:MGI.
DR GO; GO:0042110; P:T cell activation; IBA:GO_Central.
DR Gene3D; 2.60.40.10; -; 2.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013106; Ig_V-set.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 1.
DR SUPFAM; SSF48726; SSF48726; 2.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane;
KW Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..17
FT /evidence="ECO:0000255"
FT CHAIN 18..285
FT /note="SLAM family member 9"
FT /id="PRO_0000042234"
FT TOPO_DOM 18..232
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 233..253
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 254..285
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 25..126
FT /note="Ig-like V-type"
FT DOMAIN 134..213
FT /note="Ig-like C2-type"
FT CARBOHYD 37
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 97
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 141
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 149
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 175
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 206
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 154..198
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT CONFLICT 29
FT /note="I -> V (in Ref. 1; BAB26328)"
FT /evidence="ECO:0000305"
FT CONFLICT 74
FT /note="M -> T (in Ref. 2; AAH19477)"
FT /evidence="ECO:0000305"
FT CONFLICT 204
FT /note="V -> I (in Ref. 1; BAB26328)"
FT /evidence="ECO:0000305"
FT CONFLICT 210
FT /note="R -> H (in Ref. 1; BAC41061)"
FT /evidence="ECO:0000305"
FT CONFLICT 224
FT /note="P -> L (in Ref. 1; BAB26328)"
FT /evidence="ECO:0000305"
FT CONFLICT 263
FT /note="R -> W (in Ref. 1; BAC41061)"
FT /evidence="ECO:0000305"
FT CONFLICT 280
FT /note="S -> P (in Ref. 2; AAH19477)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 285 AA; 31749 MW; 27075E1AFFF06163 CRC64;
MGALLWSLLL LLQEAKGFSG DDEDPEEVIG VLQESINLSL EIPSNEEIKH IDWLFQNNIA
IVKPGKKGQP AVIMAVDPRY RGRVSISESS YSLHISNLTW EDSGLYNAQV NLKTSESHIT
KSYHLRVYRR LSKPHITVNS NISEEGVCNI SLTCSIERAG MDVTYIWLSS QDSTNTSHEG
SVLSTSWRPG DKAPSYTCRV SNPVSNISSR RISVGSFCAD PGYPEKPSML CLLVKSLFLL
LLLAILTVGL CLFRAQKSYE TPRVRKLKRN RIKLRKKGKS GPTPV
