SLAH4_ARATH
ID SLAH4_ARATH Reviewed; 365 AA.
AC A8MRV9;
DT 08-FEB-2011, integrated into UniProtKB/Swiss-Prot.
DT 04-DEC-2007, sequence version 1.
DT 03-AUG-2022, entry version 79.
DE RecName: Full=S-type anion channel SLAH4;
DE AltName: Full=SLAC1-homolog protein 4;
GN Name=SLAH4; OrderedLocusNames=At1g62262; ORFNames=F19K23;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Alexandrov N.N., Brover V.V., Troukhan M.E., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=18305482; DOI=10.1038/nature06720;
RA Negi J., Matsuda O., Nagasawa T., Oba Y., Takahashi H., Kawai-Yamada M.,
RA Uchimiya H., Hashimoto M., Iba K.;
RT "CO2 regulator SLAC1 and its homologues are essential for anion homeostasis
RT in plant cells.";
RL Nature 452:483-486(2008).
CC -!- FUNCTION: Slow, weak voltage-dependent S-type anion efflux channel
CC involved in maintenance of anion homeostasis. {ECO:0000250}.
CC -!- SUBUNIT: Homotrimer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SLAC1 S-type anion channel family.
CC {ECO:0000305}.
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DR EMBL; AC000375; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CP002684; AEE33943.1; -; Genomic_DNA.
DR EMBL; DQ108890; -; NOT_ANNOTATED_CDS; mRNA.
DR RefSeq; NP_001077757.1; NM_001084288.2.
DR AlphaFoldDB; A8MRV9; -.
DR SMR; A8MRV9; -.
DR STRING; 3702.AT1G62262.1; -.
DR iPTMnet; A8MRV9; -.
DR PaxDb; A8MRV9; -.
DR PRIDE; A8MRV9; -.
DR EnsemblPlants; AT1G62262.1; AT1G62262.1; AT1G62262.
DR GeneID; 5007829; -.
DR Gramene; AT1G62262.1; AT1G62262.1; AT1G62262.
DR KEGG; ath:AT1G62262; -.
DR Araport; AT1G62262; -.
DR TAIR; locus:4010713576; AT1G62262.
DR eggNOG; ENOG502QSGW; Eukaryota.
DR HOGENOM; CLU_044414_2_0_1; -.
DR InParanoid; A8MRV9; -.
DR OMA; HIMIDNT; -.
DR OrthoDB; 947189at2759; -.
DR PhylomeDB; A8MRV9; -.
DR PRO; PR:A8MRV9; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; A8MRV9; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008308; F:voltage-gated anion channel activity; IEA:InterPro.
DR GO; GO:0006873; P:cellular ion homeostasis; ISS:TAIR.
DR Gene3D; 1.50.10.150; -; 1.
DR InterPro; IPR030183; SLAC/SLAH.
DR InterPro; IPR004695; SLAC1/Mae1/Ssu1/TehA.
DR InterPro; IPR038665; Voltage-dep_anion_channel_sf.
DR PANTHER; PTHR31269; PTHR31269; 1.
DR Pfam; PF03595; SLAC1; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Ion transport; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..365
FT /note="S-type anion channel SLAH4"
FT /id="PRO_0000404263"
FT TOPO_DOM 1..25
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 26..46
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..73
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 74..94
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 95..106
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 107..127
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 128..131
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 132..152
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 153..168
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 169..189
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 190..199
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 200..220
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 221..235
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 236..256
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 257
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 258..278
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 279..291
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 292..312
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 313..321
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 322..342
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 343..365
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT CONFLICT 129
FT /note="S -> A (in Ref. 3; DQ108890)"
FT /evidence="ECO:0000305"
FT CONFLICT 258
FT /note="F -> C (in Ref. 3; DQ108890)"
FT /evidence="ECO:0000305"
FT CONFLICT 336..337
FT /note="IS -> LG (in Ref. 3; DQ108890)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 365 AA; 41583 MW; FC0DD205AEE56D40 CRC64;
MEIPSQEIHI MIDNTISRRK ERKTNLADAE PIVLMSVLSS LHAGYFRISL SLCSQALLWK
IMVHLHSELP SMAYYLLWYL ALATQVSLCF LYAFKCIFLF DMVKEEFSHY IGVNYLYAPS
ISCLLLLQSA PMIEPHSVLY QTLFWIFAVP VLTLDTKLYG QWFTTEKRFL SIMANPASQV
SVIANLVAAR GAAEMGWKEC ALCLFSLGMV HYLVIFVTLY QRLPGGNNFP TTLRPVFFLF
FAAPATASLA WNSICGNFDT IAKMLFFLSL FIFISLVCRP NLLKKSIKRF NVAWWAYSFP
ITFLALNSVQ YAQEVKDHVA SVLMFIFSSM SVLIFISVML LTAANSKRLL RRDHVLWSST
GPKDK
