SLAI1_HUMAN
ID SLAI1_HUMAN Reviewed; 568 AA.
AC Q8ND83; A8K0Z9; B7Z209; Q5T6P4; Q5T6P7; Q8ND10; Q96NV0;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-FEB-2008, sequence version 3.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=SLAIN motif-containing protein 1;
GN Name=SLAIN1; Synonyms=C13orf32;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3 AND 4).
RC TISSUE=Amygdala, and Brain cortex;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 210-568 (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057823; DOI=10.1038/nature02379;
RA Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L.,
RA Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S.,
RA Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P.,
RA Ambrose K.D., Andrews D.T., Ashwell R.I.S., Babbage A.K., Bagguley C.L.,
RA Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P.,
RA Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P.,
RA Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C.,
RA Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P.,
RA Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L.,
RA Frankish A.G., Frankland J., French L., Garner P., Garnett J.,
RA Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M.,
RA Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D.,
RA Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D.,
RA Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S.,
RA Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S.,
RA Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R.,
RA Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W.,
RA Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P.,
RA Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L.,
RA Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R.,
RA Rogers J., Ross M.T.;
RT "The DNA sequence and analysis of human chromosome 13.";
RL Nature 428:522-528(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 211-568 (ISOFORM 1).
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION, AND TISSUE SPECIFICITY.
RX PubMed=16546155; DOI=10.1016/j.ydbio.2006.01.023;
RA Hirst C.E., Ng E.S., Azzola L., Voss A.K., Thomas T., Stanley E.G.,
RA Elefanty A.G.;
RT "Transcriptional profiling of mouse and human ES cells identifies SLAIN1, a
RT novel stem cell gene.";
RL Dev. Biol. 293:90-103(2006).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-243, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
RN [7]
RP FUNCTION, INTERACTION WITH MAPRE1; MAPRE2; MAPRE3 AND CKAP5, SUBCELLULAR
RP LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=21646404; DOI=10.1083/jcb.201012179;
RA van der Vaart B., Manatschal C., Grigoriev I., Olieric V., Gouveia S.M.,
RA Bjelic S., Demmers J., Vorobjev I., Hoogenraad C.C., Steinmetz M.O.,
RA Akhmanova A.;
RT "SLAIN2 links microtubule plus end-tracking proteins and controls
RT microtubule growth in interphase.";
RL J. Cell Biol. 193:1083-1099(2011).
RN [8]
RP INTERACTION WITH ZDHHC17.
RX PubMed=28882895; DOI=10.1074/jbc.m117.799650;
RA Lemonidis K., MacLeod R., Baillie G.S., Chamberlain L.H.;
RT "Peptide array based screening reveals a large number of proteins
RT interacting with the ankyrin repeat domain of the zDHHC17 S-
RT acyltransferase.";
RL J. Biol. Chem. 292:17190-17202(2017).
CC -!- FUNCTION: Microtubule plus-end tracking protein that might be involved
CC in the regulation of cytoplasmic microtubule dynamics, microtubule
CC organization and microtubule elongation. {ECO:0000269|PubMed:21646404}.
CC -!- SUBUNIT: Interacts with MAPRE1, MAPRE2, MAPRE3 and CKAP5
CC (PubMed:21646404). Interacts with ZDHHC17 (via ANK repeats)
CC (PubMed:28882895). {ECO:0000269|PubMed:21646404,
CC ECO:0000269|PubMed:28882895}.
CC -!- INTERACTION:
CC Q8ND83; Q12774: ARHGEF5; NbExp=3; IntAct=EBI-10269374, EBI-602199;
CC Q8ND83; Q9H6L4: ARMC7; NbExp=3; IntAct=EBI-10269374, EBI-742909;
CC Q8ND83; Q9NX04: C1orf109; NbExp=3; IntAct=EBI-10269374, EBI-8643161;
CC Q8ND83; Q9H257-2: CARD9; NbExp=3; IntAct=EBI-10269374, EBI-11530605;
CC Q8ND83; P10606: COX5B; NbExp=3; IntAct=EBI-10269374, EBI-1053725;
CC Q8ND83; Q9BSW2: CRACR2A; NbExp=3; IntAct=EBI-10269374, EBI-739773;
CC Q8ND83; P26196: DDX6; NbExp=3; IntAct=EBI-10269374, EBI-351257;
CC Q8ND83; Q5JVL4: EFHC1; NbExp=3; IntAct=EBI-10269374, EBI-743105;
CC Q8ND83; Q96B26: EXOSC8; NbExp=3; IntAct=EBI-10269374, EBI-371922;
CC Q8ND83; Q7L5A3: FAM214B; NbExp=3; IntAct=EBI-10269374, EBI-745689;
CC Q8ND83; Q14192: FHL2; NbExp=3; IntAct=EBI-10269374, EBI-701903;
CC Q8ND83; Q13643: FHL3; NbExp=6; IntAct=EBI-10269374, EBI-741101;
CC Q8ND83; O43559: FRS3; NbExp=3; IntAct=EBI-10269374, EBI-725515;
CC Q8ND83; Q92805: GOLGA1; NbExp=3; IntAct=EBI-10269374, EBI-6164177;
CC Q8ND83; P52597: HNRNPF; NbExp=3; IntAct=EBI-10269374, EBI-352986;
CC Q8ND83; Q9NSC5: HOMER3; NbExp=3; IntAct=EBI-10269374, EBI-748420;
CC Q8ND83; P31273: HOXC8; NbExp=3; IntAct=EBI-10269374, EBI-1752118;
CC Q8ND83; O75031: HSF2BP; NbExp=3; IntAct=EBI-10269374, EBI-7116203;
CC Q8ND83; Q7L273: KCTD9; NbExp=3; IntAct=EBI-10269374, EBI-4397613;
CC Q8ND83; Q9HAQ2: KIF9; NbExp=3; IntAct=EBI-10269374, EBI-8472129;
CC Q8ND83; Q8TAP4-4: LMO3; NbExp=3; IntAct=EBI-10269374, EBI-11742507;
CC Q8ND83; Q96HA8: NTAQ1; NbExp=3; IntAct=EBI-10269374, EBI-741158;
CC Q8ND83; Q9UBU9: NXF1; NbExp=3; IntAct=EBI-10269374, EBI-398874;
CC Q8ND83; Q9HBE1-4: PATZ1; NbExp=3; IntAct=EBI-10269374, EBI-11022007;
CC Q8ND83; P55771: PAX9; NbExp=3; IntAct=EBI-10269374, EBI-12111000;
CC Q8ND83; Q9NR12: PDLIM7; NbExp=3; IntAct=EBI-10269374, EBI-350517;
CC Q8ND83; Q99471: PFDN5; NbExp=3; IntAct=EBI-10269374, EBI-357275;
CC Q8ND83; Q7Z5V6-2: PPP1R32; NbExp=3; IntAct=EBI-10269374, EBI-12000762;
CC Q8ND83; Q8WWY3: PRPF31; NbExp=3; IntAct=EBI-10269374, EBI-1567797;
CC Q8ND83; P25788: PSMA3; NbExp=3; IntAct=EBI-10269374, EBI-348380;
CC Q8ND83; O75679: RFPL3; NbExp=5; IntAct=EBI-10269374, EBI-10188956;
CC Q8ND83; Q9NU19: TBC1D22B; NbExp=3; IntAct=EBI-10269374, EBI-8787464;
CC Q8ND83; Q7Z6R9: TFAP2D; NbExp=3; IntAct=EBI-10269374, EBI-11952651;
CC Q8ND83; Q96PN8: TSSK3; NbExp=3; IntAct=EBI-10269374, EBI-3918381;
CC Q8ND83; P36508: ZNF76; NbExp=3; IntAct=EBI-10269374, EBI-7254550;
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000269|PubMed:21646404}. Note=Colocalizes with microtubules.
CC Detected at the plus end of growing microtubules.
CC {ECO:0000269|PubMed:21646404}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q8ND83-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8ND83-2; Sequence=VSP_030832;
CC Name=3;
CC IsoId=Q8ND83-3; Sequence=VSP_030832, VSP_043256, VSP_043257;
CC Name=4;
CC IsoId=Q8ND83-4; Sequence=VSP_054118;
CC -!- TISSUE SPECIFICITY: Expressed in embryonic stem cells
CC (PubMed:16546155). Expressed in brain (PubMed:21646404).
CC {ECO:0000269|PubMed:16546155, ECO:0000269|PubMed:21646404}.
CC -!- SIMILARITY: Belongs to the SLAIN motif-containing family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI11498.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=CAD39000.2; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK054608; BAB70772.1; -; mRNA.
DR EMBL; AK289600; BAF82289.1; -; mRNA.
DR EMBL; AK289714; BAF82403.1; -; mRNA.
DR EMBL; AK294201; BAH11695.1; -; mRNA.
DR EMBL; AL834203; CAD38891.1; -; mRNA.
DR EMBL; AL834332; CAD39000.2; ALT_INIT; mRNA.
DR EMBL; AL354831; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC111497; AAI11498.1; ALT_INIT; mRNA.
DR CCDS; CCDS31995.2; -. [Q8ND83-4]
DR CCDS; CCDS55901.1; -. [Q8ND83-3]
DR CCDS; CCDS9460.1; -. [Q8ND83-2]
DR RefSeq; NP_001035243.2; NM_001040153.3. [Q8ND83-4]
DR RefSeq; NP_001229798.1; NM_001242869.1. [Q8ND83-3]
DR RefSeq; NP_001229799.1; NM_001242870.1. [Q8ND83-3]
DR RefSeq; NP_653196.1; NM_144595.3. [Q8ND83-2]
DR RefSeq; XP_011533232.1; XM_011534930.1.
DR AlphaFoldDB; Q8ND83; -.
DR SMR; Q8ND83; -.
DR BioGRID; 125759; 90.
DR IntAct; Q8ND83; 46.
DR STRING; 9606.ENSP00000400921; -.
DR GlyGen; Q8ND83; 2 sites, 1 O-linked glycan (2 sites).
DR iPTMnet; Q8ND83; -.
DR MetOSite; Q8ND83; -.
DR PhosphoSitePlus; Q8ND83; -.
DR BioMuta; SLAIN1; -.
DR DMDM; 166977707; -.
DR EPD; Q8ND83; -.
DR MassIVE; Q8ND83; -.
DR MaxQB; Q8ND83; -.
DR PaxDb; Q8ND83; -.
DR PeptideAtlas; Q8ND83; -.
DR PRIDE; Q8ND83; -.
DR ProteomicsDB; 72988; -. [Q8ND83-1]
DR ProteomicsDB; 72989; -. [Q8ND83-2]
DR ProteomicsDB; 72990; -. [Q8ND83-3]
DR ProteomicsDB; 72991; -. [Q8ND83-4]
DR TopDownProteomics; Q8ND83-1; -. [Q8ND83-1]
DR Antibodypedia; 24633; 158 antibodies from 27 providers.
DR DNASU; 122060; -.
DR Ensembl; ENST00000314070.9; ENSP00000314443.5; ENSG00000139737.22. [Q8ND83-3]
DR Ensembl; ENST00000358679.3; ENSP00000351507.2; ENSG00000139737.22. [Q8ND83-2]
DR Ensembl; ENST00000466548.5; ENSP00000419730.1; ENSG00000139737.22. [Q8ND83-1]
DR Ensembl; ENST00000488699.5; ENSP00000418707.1; ENSG00000139737.22. [Q8ND83-4]
DR GeneID; 122060; -.
DR KEGG; hsa:122060; -.
DR UCSC; uc001vkm.3; human. [Q8ND83-1]
DR CTD; 122060; -.
DR DisGeNET; 122060; -.
DR GeneCards; SLAIN1; -.
DR HGNC; HGNC:26387; SLAIN1.
DR HPA; ENSG00000139737; Tissue enriched (brain).
DR MIM; 610491; gene.
DR neXtProt; NX_Q8ND83; -.
DR OpenTargets; ENSG00000139737; -.
DR PharmGKB; PA162403440; -.
DR VEuPathDB; HostDB:ENSG00000139737; -.
DR eggNOG; ENOG502QVWF; Eukaryota.
DR GeneTree; ENSGT00390000017860; -.
DR HOGENOM; CLU_027278_1_0_1; -.
DR InParanoid; Q8ND83; -.
DR PhylomeDB; Q8ND83; -.
DR TreeFam; TF331616; -.
DR PathwayCommons; Q8ND83; -.
DR SignaLink; Q8ND83; -.
DR BioGRID-ORCS; 122060; 9 hits in 1069 CRISPR screens.
DR ChiTaRS; SLAIN1; human.
DR GenomeRNAi; 122060; -.
DR Pharos; Q8ND83; Tdark.
DR PRO; PR:Q8ND83; -.
DR Proteomes; UP000005640; Chromosome 13.
DR RNAct; Q8ND83; protein.
DR Bgee; ENSG00000139737; Expressed in C1 segment of cervical spinal cord and 144 other tissues.
DR ExpressionAtlas; Q8ND83; baseline and differential.
DR Genevisible; Q8ND83; HS.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0031122; P:cytoplasmic microtubule organization; IBA:GO_Central.
DR GO; GO:0007020; P:microtubule nucleation; IBA:GO_Central.
DR GO; GO:0031116; P:positive regulation of microtubule polymerization; IBA:GO_Central.
DR InterPro; IPR026179; Slain.
DR PANTHER; PTHR22406; PTHR22406; 2.
DR Pfam; PF15301; SLAIN; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Cytoplasm; Cytoskeleton; Methylation;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..568
FT /note="SLAIN motif-containing protein 1"
FT /id="PRO_0000316962"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 59..92
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 139..162
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 235..256
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 291..403
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 21..56
FT /evidence="ECO:0000255"
FT COMPBIAS 59..79
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 236..256
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 291..318
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 347..400
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 243
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19690332"
FT MOD_RES 471
FT /note="Asymmetric dimethylarginine"
FT /evidence="ECO:0000250|UniProtKB:Q68FF7"
FT MOD_RES 543
FT /note="Asymmetric dimethylarginine"
FT /evidence="ECO:0000250|UniProtKB:Q68FF7"
FT VAR_SEQ 1..263
FT /note="Missing (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:17974005"
FT /id="VSP_030832"
FT VAR_SEQ 1..187
FT /note="MMAEQVKCASAGVSSGAGSGPVVNAELEVKKLQELVRKLEKQNEQLRSRAAS
FT AAAAPHLLLLPPPPPAAPPPAGLQPLGPRSPPAATATAAASGGLGPAFPGTFCLPSPAP
FT SLLCSLAQPPEAPFVYFKPAAGFFGAGGGGPEPGGAGTPPGAAAAPPSPPPTLLDEVEL
FT LDLESVAAWRDEDDYTW -> MVGVGLCLRLLLFFRFKRTLDRICVLFLLGWHRKPRSD
FT GSLFIER (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_054118"
FT VAR_SEQ 284..397
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:17974005"
FT /id="VSP_043256"
FT VAR_SEQ 398
FT /note="D -> N (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:17974005"
FT /id="VSP_043257"
FT CONFLICT 399
FT /note="K -> R (in Ref. 1; BAF82403)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 568 AA; 60595 MW; 206E9C7C92265321 CRC64;
MMAEQVKCAS AGVSSGAGSG PVVNAELEVK KLQELVRKLE KQNEQLRSRA ASAAAAPHLL
LLPPPPPAAP PPAGLQPLGP RSPPAATATA AASGGLGPAF PGTFCLPSPA PSLLCSLAQP
PEAPFVYFKP AAGFFGAGGG GPEPGGAGTP PGAAAAPPSP PPTLLDEVEL LDLESVAAWR
DEDDYTWLYI GSSKTFTSSE KSLTPLQWCR HVLDNPTPEM EAARRSLCFR LEQGYTSRGS
PLSPQSSIDS ELSTSELEDD SISMGYKLQD LTDVQIMARL QEESLRQDYA STSASVSRHS
SSVSLSSGKK GTCSDQEYDQ YSLEDEEEFD HLPPPQPRLP RCSPFQRGIP HSQTFSSIRE
CRRSPSSQYF PSNNYQQQQY YSPQAQTPDQ QPNRTNGDKL RRSMPNLARM PSTTAISSNI
SSPVTVRNSQ SFDSSLHGAG NGISRIQSCI PSPGQLQHRV HSVGHFPVSI RQPLKATAYV
SPTVQGSSNM PLSNGLQLYS NTGIPTPNKA AASGIMGRSA LPRPSLAING SNLPRSKIAQ
PVRSFLQPPK PLSSLSTLRD GNWRDGCY
