ID   SLAI1_XENTR             Reviewed;         545 AA.
AC   A8E4V2;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 2.
DT   03-AUG-2022, entry version 51.
DE   RecName: Full=SLAIN motif-containing protein 1;
GN   Name=slain1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Microtubule plus-end tracking protein that might be involved
CC       in the regulation of cytoplasmic microtubule dynamics, microtubule
CC       organization and microtubule elongation.
CC       {ECO:0000250|UniProtKB:Q68FF7}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC       {ECO:0000250|UniProtKB:Q68FF7}. Note=Colocalizes with microtubules.
CC       Detected at the plus end of growing microtubules.
CC       {ECO:0000250|UniProtKB:Q68FF7}.
CC   -!- SIMILARITY: Belongs to the SLAIN motif-containing family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAI53340.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC153339; AAI53340.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001106409.2; NM_001112938.1.
DR   AlphaFoldDB; A8E4V2; -.
DR   SMR; A8E4V2; -.
DR   STRING; 8364.ENSXETP00000033732; -.
DR   DNASU; 100127571; -.
DR   Ensembl; ENSXETT00000033732; ENSXETP00000033732; ENSXETG00000015457.
DR   GeneID; 100127571; -.
DR   KEGG; xtr:100127571; -.
DR   CTD; 122060; -.
DR   Xenbase; XB-GENE-5793178; slain1.
DR   eggNOG; ENOG502QVWF; Eukaryota.
DR   InParanoid; A8E4V2; -.
DR   OrthoDB; 658136at2759; -.
DR   Proteomes; UP000008143; Chromosome 2.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000015457; Expressed in brain and 2 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0031122; P:cytoplasmic microtubule organization; IBA:GO_Central.
DR   GO; GO:0007020; P:microtubule nucleation; IBA:GO_Central.
DR   GO; GO:0031116; P:positive regulation of microtubule polymerization; IBA:GO_Central.
DR   InterPro; IPR026179; Slain.
DR   PANTHER; PTHR22406; PTHR22406; 2.
DR   Pfam; PF15301; SLAIN; 2.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Cytoskeleton; Reference proteome.
FT   CHAIN           1..545
FT                   /note="SLAIN motif-containing protein 1"
FT                   /id="PRO_0000316964"
FT   REGION          268..342
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          461..526
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          14..53
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        268..292
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        324..342
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        461..493
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        501..526
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   545 AA;  59175 MW;  E99C20659BAA415B CRC64;
     MAEVKCSSST GSPTTNGLVA NAELEVKKLQ ELVRKLEKQN EQLRNRASAV SNCTPSPHLL
     LQHPPSVVHQ SGTCILSSPV LTRPAGLCLP SPVPTLLCTS AVAGSLFSPE SMGCFSTNKR
     LHLSCINAAE GPQNDCPVPG STLLDEVQVL DLEDGYCSGD EDTWLYVSPT KDQRTFDSSV
     SPLQWCRQVL DHPSPEIEAA KRSLCFRLEQ GYTVKTSHLS PQSSVDSELS TSELEDDSIS
     MGYKLQDLTD VQIMARLQEE SLRQDFATTS TCSSVSRPRS SFSLYSGKKL SCSSDQDSDR
     YSVEEDDEDF DHLPPPQPRL SRCSPLQRGL SHSQTFSSIR DCRKSPSSQF LNGYQQYNYS
     SQPQTTEQSQ SRTNADKLRR SMPNLARMPS TNNNPVVSMT TVRNSQSFDS NLHGAANGVS
     RMQSSIPSPG QLQQRVHSVG HFPVSVRPPL KATAYVSPTV QGGSGIPSST SLQSLSSSGI
     PMPNKTTSAA TIGRSALPRP ALSTANGSSI PRSKIAQPQR SFLQPPKTLA SLSTLRDGNW
     RDGCY