ID   SLAM1_HAEIN             Reviewed;         481 AA.
AC   P44087;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   07-OCT-2020, sequence version 2.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Surface lipoprotein assembly modifier 1;
DE            Short=Slam;
DE   Flags: Precursor;
GN   OrderedLocusNames=HI_0974;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- FUNCTION: Required for correct export to the cell surface of some cell
CC       outer membrane lipoproteins. {ECO:0000250|UniProtKB:Q4QLR4}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane
CC       {ECO:0000250|UniProtKB:Q4QLR4}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- DOMAIN: Consists of a soluble N-terminal domain and C-terminal probable
CC       beta-barrel in the outer membrane with 14 predicted beta-strands.
CC       {ECO:0000250|UniProtKB:Q9K165}.
CC   -!- SIMILARITY: Belongs to the Slam family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAC22642.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
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DR   EMBL; L42023; AAC22642.1; ALT_SEQ; Genomic_DNA.
DR   PIR; F64017; F64017.
DR   AlphaFoldDB; P44087; -.
DR   STRING; 71421.HI_0974; -.
DR   PRIDE; P44087; -.
DR   EnsemblBacteria; AAC22642; AAC22642; HI_0974.
DR   KEGG; hin:HI_0974; -.
DR   eggNOG; COG4783; Bacteria.
DR   HOGENOM; CLU_034927_1_0_6; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR007655; Slam.
DR   Pfam; PF04575; SlipAM; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Membrane; Reference proteome; Signal; Transmembrane;
KW   Transmembrane beta strand.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..481
FT                   /note="Surface lipoprotein assembly modifier 1"
FT                   /id="PRO_0000077985"
FT   TRANSMEM        194..204
FT                   /note="Beta stranded"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        233..243
FT                   /note="Beta stranded"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        248..258
FT                   /note="Beta stranded"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        271..281
FT                   /note="Beta stranded"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        285..295
FT                   /note="Beta stranded"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        315..325
FT                   /note="Beta stranded"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        329..338
FT                   /note="Beta stranded"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        353..363
FT                   /note="Beta stranded"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        368..377
FT                   /note="Beta stranded"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        390..400
FT                   /note="Beta stranded"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        405..414
FT                   /note="Beta stranded"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        432..441
FT                   /note="Beta stranded"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        448..458
FT                   /note="Beta stranded"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        471..481
FT                   /note="Beta stranded"
FT                   /evidence="ECO:0000255"
FT   REGION          25..192
FT                   /note="N-terminal domain"
FT                   /evidence="ECO:0000250|UniProtKB:Q9K165"
FT   REGION          193..481
FT                   /note="C-terminal probable beta barrel"
FT                   /evidence="ECO:0000250|UniProtKB:Q9K165"
SQ   SEQUENCE   481 AA;  55562 MW;  EABF93B6D9617196 CRC64;
     MSIQTKFILF LSSSLFLTPY SVATEKSPQP HDGRLDEQLH LAKPNLPQKT PALLTNNNPS
     KLSITKEELA KHPDLIIRGL IPAVLQNNGE AVQLLLPLYQ PLPKKDPFLL EWAEAIDLRE
     KGYFSDSVKA YRHLFSQKTD LLPLRYQLAQ ALFLNNDNEA AKDQFQKLRA EQVSSDSVKI
     IEQYLSALNQ RDQWKIQGGF SFLNESNINN APKAGTKIGN WTAWEKESAR GFSYFGNAEK
     KWSLPHNHFT KLSLEGSGKY YWDNKKYNEF NARAGVGLGY QTARFELSLM PFTEKRWYAG
     GSSGGNAMKQ YSKNSGARLD LSNWLNEKWQ ISTALEYGEQ RYETRKHLNG NNYLASATLL
     YLAKSGQYWF GGADYNRENT RDLDNAYQRK NVRLGWGQEW KAGISTRLIL NYARRAYKEK
     DLIGIRQKNK EYASVLTIWH RNFHIWGITP KLSWSYQKVT SNHPFYEYDK NRIYVEISKT
     F