ID   SLAM2_HAEIN             Reviewed;         481 AA.
AC   P44089; P44090;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   07-OCT-2020, sequence version 2.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=Surface lipoprotein assembly modifier 2;
DE            Short=Slam;
DE   Flags: Precursor;
GN   OrderedLocusNames=HI_0996, HI_0997;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- FUNCTION: Required for correct export to the cell surface of some cell
CC       outer membrane lipoproteins. {ECO:0000250|UniProtKB:Q4QLR4}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane
CC       {ECO:0000250|UniProtKB:Q4QLR4}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- DOMAIN: Consists of a soluble N-terminal domain and C-terminal probable
CC       beta-barrel in the outer membrane with 14 predicted beta-strands.
CC       {ECO:0000250|UniProtKB:Q9K165}.
CC   -!- SIMILARITY: Belongs to the Slam family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAC22658.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
CC       Sequence=AAC22659.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; L42023; AAC22658.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; L42023; AAC22659.1; ALT_INIT; Genomic_DNA.
DR   PIR; H64017; H64017.
DR   AlphaFoldDB; P44089; -.
DR   SMR; P44089; -.
DR   STRING; 71421.HI_0996; -.
DR   EnsemblBacteria; AAC22658; AAC22658; HI_0996.
DR   EnsemblBacteria; AAC22659; AAC22659; HI_0997.
DR   KEGG; hin:HI_0996; -.
DR   KEGG; hin:HI_0997; -.
DR   eggNOG; COG4783; Bacteria.
DR   HOGENOM; CLU_1774801_0_0_6; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR007655; Slam.
DR   Pfam; PF04575; SlipAM; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Membrane; Reference proteome; Signal; Transmembrane;
KW   Transmembrane beta strand.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..481
FT                   /note="Surface lipoprotein assembly modifier 2"
FT                   /id="PRO_0000077989"
FT   TRANSMEM        194..204
FT                   /note="Beta stranded"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        223..243
FT                   /note="Beta stranded"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        248..257
FT                   /note="Beta stranded"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        271..281
FT                   /note="Beta stranded"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        285..295
FT                   /note="Beta stranded"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        315..325
FT                   /note="Beta stranded"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        329..339
FT                   /note="Beta stranded"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        353..363
FT                   /note="Beta stranded"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        368..377
FT                   /note="Beta stranded"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        390..399
FT                   /note="Beta stranded"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        404..414
FT                   /note="Beta stranded"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        432..441
FT                   /note="Beta stranded"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        448..458
FT                   /note="Beta stranded"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        471..481
FT                   /note="Beta stranded"
FT                   /evidence="ECO:0000255"
FT   REGION          24..192
FT                   /note="N-terminal domain"
FT                   /evidence="ECO:0000250|UniProtKB:Q9K165"
FT   REGION          193..481
FT                   /note="C-terminal probable beta barrel"
FT                   /evidence="ECO:0000250|UniProtKB:Q9K165"
SQ   SEQUENCE   481 AA;  56139 MW;  E8E1096D7FAB8628 CRC64;
     MKNGVKQLFL LSLIGLSLTN VAWAEVARPK NDTLTNTIQS AELKTSSFSS MPKKEIPNRH
     IISLSKSQLA HHPRLVLRGL IPALYQNNTQ AVQLLLPLYK QFPQQDNFLL TWAKAIEARE
     QGDLTQSIAY YRELFARDAS LLPLRYQLAQ ALFFNYENEA AKIQFEKLRT EVDDEKFLGV
     IDQYLLTLNQ RNQWIWQVGL NFLNDDNLNN APKSGTKIGS WTAWEKESGQ GVGYSLSVEK
     KWPWADHFFS KTMFNGNGKY YWDNKKYNEA TVRIGGGLGY QTASVEVSLF PFQEKRWYAG
     GSSGTNTMKQ YADKLGIRLE NVDWLSKTWQ ISTALEYGES RYKIRKHLDG NYYFVSSTLF
     YLPKSTQFWF VGMDFHRENT QALDNAYQQK TLRLGWGQDW FYGISSRLTF SYANRVYREK
     DLIGIQQKNR EYTTTITLWH RNIHFMGLTP KLSWDYQKST SNHAFYRYDK NRIYLEIGKI
     F