ID   SLAM_MORCA              Reviewed;         503 AA.
AC   P0DTW8;
DT   07-OCT-2020, integrated into UniProtKB/Swiss-Prot.
DT   07-OCT-2020, sequence version 1.
DT   25-MAY-2022, entry version 6.
DE   RecName: Full=Surface lipoprotein assembly modifier {ECO:0000303|PubMed:28620585};
DE            Short=Slam {ECO:0000303|PubMed:28620585};
DE   Flags: Precursor;
GN   ORFNames=EA1_03410;
OS   Moraxella catarrhalis (Branhamella catarrhalis).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Moraxellales; Moraxellaceae;
OC   Moraxella.
OX   NCBI_TaxID=480;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O53E;
RX   PubMed=21269504; DOI=10.1186/1471-2164-12-70;
RA   Davie J.J., Earl J., de Vries S.P., Ahmed A., Hu F.Z., Bootsma H.J.,
RA   Stol K., Hermans P.W., Wadowsky R.M., Ehrlich G.D., Hays J.P.,
RA   Campagnari A.A.;
RT   "Comparative analysis and supragenome modeling of twelve Moraxella
RT   catarrhalis clinical isolates.";
RL   BMC Genomics 12:70-70(2011).
RN   [2]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RC   STRAIN=O53E;
RX   PubMed=28620585; DOI=10.3389/fcimb.2017.00207;
RA   Hooda Y., Lai C.C.L., Moraes T.F.;
RT   "Identification of a Large Family of Slam-Dependent Surface Lipoproteins in
RT   Gram-Negative Bacteria.";
RL   Front. Cell. Infect. Microbiol. 7:207-207(2017).
CC   -!- FUNCTION: Required for correct export to the cell surface of some cell
CC       outer membrane lipoproteins (tested with TpbP) upon heterologous
CC       expression in E.coli and probably also in Moraxella.
CC       {ECO:0000269|PubMed:28620585}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane
CC       {ECO:0000305|PubMed:28620585}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- DOMAIN: Consists of a soluble N-terminal domain and C-terminal probable
CC       beta-barrel in the outer membrane with 14 predicted beta-strands.
CC       {ECO:0000250|UniProtKB:Q9K165}.
CC   -!- SIMILARITY: Belongs to the Slam family. {ECO:0000305}.
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DR   EMBL; AERL01000018; EGE27320.1; -; Genomic_DNA.
DR   RefSeq; WP_003667641.1; NZ_RCKS01000001.1.
DR   AlphaFoldDB; P0DTW8; -.
DR   SMR; P0DTW8; -.
DR   KEGG; mcs:DR90_1244; -.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.40.10; -; 1.
DR   InterPro; IPR007655; Slam.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   Pfam; PF04575; SlipAM; 1.
DR   SUPFAM; SSF48452; SSF48452; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Membrane; Signal; TPR repeat; Transmembrane;
KW   Transmembrane beta strand.
FT   SIGNAL          1..34
FT                   /evidence="ECO:0000255"
FT   CHAIN           35..503
FT                   /note="Surface lipoprotein assembly modifier"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000450808"
FT   TRANSMEM        222..232
FT                   /note="Beta stranded"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        259..270
FT                   /note="Beta stranded"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        275..285
FT                   /note="Beta stranded"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        299..308
FT                   /note="Beta stranded"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        313..322
FT                   /note="Beta stranded"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        334..343
FT                   /note="Beta stranded"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        348..358
FT                   /note="Beta stranded"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        372..382
FT                   /note="Beta stranded"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        387..396
FT                   /note="Beta stranded"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        410..419
FT                   /note="Beta stranded"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        424..434
FT                   /note="Beta stranded"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        454..463
FT                   /note="Beta stranded"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        470..479
FT                   /note="Beta stranded"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        493..503
FT                   /note="Beta stranded"
FT                   /evidence="ECO:0000255"
FT   REPEAT          136..169
FT                   /note="TPR"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00339"
FT   REGION          38..220
FT                   /note="N-terminal domain"
FT                   /evidence="ECO:0000250|UniProtKB:Q9K165"
FT   REGION          221..503
FT                   /note="C-terminal probable beta barrel"
FT                   /evidence="ECO:0000250|UniProtKB:Q9K165"
SQ   SEQUENCE   503 AA;  57211 MW;  F8F042FD8C212A77 CRC64;
     MTITPVYTTF TPTKTPIKFF MAGLTFLIAH ISHADDGRTD NQEPINQEIA TLEPIINHAQ
     PELLSHDALT PKIEPILAQT PNPAEDTLIA DEALLLDNPD LLNHALNSAV MTNHMAGVHA
     LLPIYQKLPK DHQNGILLGY ANALAALDKG NAKKAIDELR RIIAIMPEYN VVRFHLARAL
     FMDKQNEAAL DQFNKLHADN LPEEVRQVVG QYRQALKQRD SWTWQVGMNL AKEDNINQTP
     KNTTQGQWTF DKPIDAITLS YQLGADKKWS LPKGAYVGAN AQIYGKHHQN HKKYNDHWGR
     LGANLGFADA KKDLSIETYG EKRFYGHERY TDTIGIRMSV DYRINPKFQS LNAIDISRLT
     NHRTPRADSN NTLYSTSLIY YPNATRYYLL GADFYDEKVP QDPSDSYQRR GIRTAWGQEW
     AGGLSSRAQI SINKRHYQGA NLTSGGQIRH DKQMQASLSL WHRDIHKWGI TPRLTISTNI
     NKSNDIKANY HKNQMFVEFS RIF