ID   SLAP1_THET8             Reviewed;         928 AA.
AC   Q5SH37;
DT   29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=S-layer protein;
DE   AltName: Full=P100 protein;
DE   AltName: Full=Surface layer protein;
DE   Flags: Precursor;
GN   Name=slpA; OrderedLocusNames=TTHA1893;
OS   Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8).
OC   Bacteria; Deinococcus-Thermus; Deinococci; Thermales; Thermaceae; Thermus.
OX   NCBI_TaxID=300852;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 27634 / DSM 579 / HB8;
RA   Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T.,
RA   Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.;
RT   "Complete genome sequence of Thermus thermophilus HB8.";
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: The S-layer is a paracrystalline mono-layered assembly of
CC       proteins which coat the surface of bacteria. {ECO:0000250}.
CC   -!- SUBUNIT: Forms trimers in the presence of calcium. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted, cell wall, S-layer {ECO:0000250}.
CC       Note=This bacterium is covered by a S-layer with hexagonal symmetry.
CC       {ECO:0000250}.
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DR   EMBL; AP008226; BAD71716.1; -; Genomic_DNA.
DR   RefSeq; WP_011228992.1; NC_006461.1.
DR   RefSeq; YP_145159.1; NC_006461.1.
DR   AlphaFoldDB; Q5SH37; -.
DR   SMR; Q5SH37; -.
DR   STRING; 300852.55773275; -.
DR   EnsemblBacteria; BAD71716; BAD71716; BAD71716.
DR   GeneID; 3168016; -.
DR   KEGG; ttj:TTHA1893; -.
DR   PATRIC; fig|300852.9.peg.1860; -.
DR   eggNOG; COG0497; Bacteria.
DR   HOGENOM; CLU_310736_0_0_0; -.
DR   OMA; ELKAQPM; -.
DR   Proteomes; UP000000532; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0030115; C:S-layer; IEA:UniProtKB-SubCell.
DR   InterPro; IPR001119; SLH_dom.
DR   Pfam; PF00395; SLH; 1.
DR   PROSITE; PS51272; SLH; 1.
PE   3: Inferred from homology;
KW   Cell wall; Reference proteome; S-layer; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..928
FT                   /note="S-layer protein"
FT                   /id="PRO_0000032640"
FT   DOMAIN          24..84
FT                   /note="SLH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00777"
SQ   SEQUENCE   928 AA;  98037 MW;  9AE3D8978A4A4F76 CRC64;
     MKKRLVTLLA GLLTVLSMGF GLAQFSDVPA GHWAKEAVEA LAAKGIILGF PDGTFRGNEN
     LTRYQAALLI YRLLQQIEEE LKTQGTSPTM EALAPEDLEA LKNAVQELAA ELASLGVRVS
     ALEDSAATKE DIARLEAMIA ELKAQPMPEP GMDQAALKDL MDRVEAASIA ADTALAQAQQ
     LAERLDALAQ DVEGVKGDLA GLRSQVEANA DAIQALNELA VLLNQDVLSL QDRVTALEKM
     VSGGQELPDL EQFATKEDVA AVQEFAAALR SDLVGLSDKV SKLEEQVAEL NKVRYSISGS
     LSATYGTVVT DTGTNFDIDR LFPGNAFSTG TYGSFSSSVQ AGDSNQGNIS GGSASLTFGV
     KVAQPGTSGV NVSEASATLQ VPAAFGTAYT SAPTIRLNAA SVKGNVDGQA FSVVYSRAVS
     SFKFNDYLFA NDNDSEPANP RQGMVATFSA TKFPLAPEVT VVAGVAGPDA TKDTAPALNG
     NYFGIRTAVK PFSALNLALN YATNLGNRSA IGVDGGLELG PAKLSGLWVS SQTPGSPFAD
     FFDNTLSDWA YYAQAEAKLG PLSLSANYHA VDPQYADGQA GMSENEDTTY YGGEKAGAPY
     GADTRGLGVS ASVGFGPVTL KGYAESEGDY NLAPGSVNDA WGVAATLGSF RGFSLTGFYN
     AAYTGGNGYF SLTTAVDAIA PGVTYYYTIE NQKYSSSWGV RVAHDGKAED ALIPTLNLTA
     QYATYYVSGH TDIQVYADLA KPFKLAILSL SPGFRYHSFA GAGSAPTYTT LKGGVQVSTD
     PLLFGLSLDG AVSYRRTQYT NNPSNVTTYE LYYRAGVKLQ DFLAPKLNFS VAYAHYEGDQ
     LAGTGLPVVG SGNQAFNFAR DRVYRSPDPI AAPWLATPGT QAGKLDGFYI EAKYYDLTVA
     YGEFVLDDLN GTNPNFGRGF KISYTVKF