ID   SLAP2_THET8             Reviewed;         917 AA.
AC   P35830; Q6LCW2;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=S-layer protein;
DE   AltName: Full=P100 protein;
DE   AltName: Full=Surface layer protein;
DE   Flags: Precursor;
GN   Name=slpA; Synonyms=slb;
OS   Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8).
OC   Bacteria; Deinococcus-Thermus; Deinococci; Thermales; Thermaceae; Thermus.
OX   NCBI_TaxID=300852;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1429468; DOI=10.1128/jb.174.22.7458-7462.1992;
RA   Faraldo M.M., de Pedro M.A., Berenguer J.;
RT   "Sequence of the S-layer gene of Thermus thermophilus HB8 and functionality
RT   of its promoter in Escherichia coli.";
RL   J. Bacteriol. 174:7458-7462(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-11.
RX   PubMed=7476196; DOI=10.1111/j.1365-2958.1995.mmi_17010001.x;
RA   Fernandez-Herrero L.A., Badet-Denisot M.-A., Badet B., Berenguer J.;
RT   "glmS of Thermus thermophilus HB8: an essential gene for cell-wall
RT   synthesis identified immediately upstream of the S-layer gene.";
RL   Mol. Microbiol. 17:1-12(1995).
CC   -!- FUNCTION: The S-layer is a paracrystalline mono-layered assembly of
CC       proteins which coat the surface of bacteria.
CC   -!- SUBUNIT: Forms trimers in the presence of calcium.
CC   -!- SUBCELLULAR LOCATION: Secreted, cell wall, S-layer. Note=This bacterium
CC       is covered by a S-layer with hexagonal symmetry.
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DR   EMBL; X57333; CAA40609.1; -; Genomic_DNA.
DR   EMBL; U17352; AAA86987.1; -; Genomic_DNA.
DR   PIR; S26365; S26365.
DR   AlphaFoldDB; P35830; -.
DR   SMR; P35830; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0030115; C:S-layer; IEA:UniProtKB-SubCell.
DR   InterPro; IPR001119; SLH_dom.
DR   Pfam; PF00395; SLH; 1.
DR   PROSITE; PS51272; SLH; 1.
PE   3: Inferred from homology;
KW   Cell wall; S-layer; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..917
FT                   /note="S-layer protein"
FT                   /id="PRO_0000032641"
FT   DOMAIN          24..84
FT                   /note="SLH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00777"
SQ   SEQUENCE   917 AA;  96133 MW;  16175929CF4CB78F CRC64;
     MKKRLVTLLA GLLTVLSMGF GLAQFSDVPA GHWAKEAVEA LAAKGIILGF PDGTFRGNEN
     LTRYQAALLI YRLLQQIEEE LKTQGTSPTM EALAPEDLEA MIAELKAQPM PEPGMDQAAL
     KDLMDRVEAA SIAADTALAQ AQQLAERLDA LAQDVEGVKG DLAGLRSQVE ANADAIQALN
     ELAVLLNQDV LSLQDRVTAL EKMVSGGQEL PDLEQFATKE DVAAVQEFAA ALRSDLVGLS
     EKVSKLEGTV GDLSGKVATL QRNAFTISGS LSLNYSVYRA WGPDASAAGP GTANTFDIDR
     LFSSKFSTGD GNGNGSVGDE ADLGKNTEGV TNATLSVSFS TGKLDAASDP GKLNSYPGLV
     QFSLRAKLTN PGKYDPSTGA PTYPINLTLD EFSSTLAVAK DQTLSFSFGR SVRSKFTEYV
     FDNDYNSRGH GFVATYKPGL LGATLTGVYG SKGANNGDFT YFRGARLALS PVEGIALGGS
     FVQEGLDANQ GTTSASFPAP TTVYGVDASV KLGPVGLAGE YFNSDAAPNA NGYYVKADVA
     LGSISVAGNY RNIGAGVTGA NMLSGDATST LDQGGWGGVD SSGNVINGAP FRSNRQGFGV
     SASAGLGPIT VKGYYDSSTV LANETITNSY GAFNYSANNQ LVAYGGQADL AFGGFTLSGF
     YRIAQLNGST TRYILTEKPA EAVYASEYGA KLAHDGASKD ALVPKLNFTA AYTQKYDNAT
     SGFTTQDIAV YGSYELALGP LTLKPMGRYH TQDAAAASTS SDYTTVKYGV AASIALDLPF
     KPSLSGEYYA RSTQVTSANS GSSATGTISE SKYAVGLKLG EFLFKNSSVE AKYASYTGSG
     LNAPILLGVA DAASSTTSDY LYNNAVSSVG SNRGSVTGWY FTWTYWDLTF AYVEADVNNN
     GNQTHGQAFK ISYTVKF