ID   BHSA_ECO57              Reviewed;          85 AA.
AC   P0AB42; P75953;
DT   11-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Multiple stress resistance protein BhsA;
DE   AltName: Full=Copper-induced outer membrane component;
DE   Flags: Precursor;
GN   Name=bhsA; Synonyms=comC; OrderedLocusNames=Z1751, ECs1490;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA   Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA   Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA   Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA   Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA   Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA   Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA   Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT   genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: Reduces the permeability of the outer membrane to copper. May
CC       be involved in the regulation of biofilm formation (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the BhsA/McbA family. {ECO:0000305}.
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DR   EMBL; AE005174; AAG55858.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB34913.1; -; Genomic_DNA.
DR   PIR; B90815; B90815.
DR   PIR; F85674; F85674.
DR   RefSeq; NP_309517.1; NC_002695.1.
DR   RefSeq; WP_000800153.1; NZ_SWKA01000005.1.
DR   AlphaFoldDB; P0AB42; -.
DR   SMR; P0AB42; -.
DR   STRING; 155864.EDL933_1690; -.
DR   EnsemblBacteria; AAG55858; AAG55858; Z1751.
DR   EnsemblBacteria; BAB34913; BAB34913; ECs_1490.
DR   GeneID; 66670622; -.
DR   GeneID; 912348; -.
DR   KEGG; ece:Z1751; -.
DR   KEGG; ecs:ECs_1490; -.
DR   PATRIC; fig|386585.9.peg.1591; -.
DR   eggNOG; ENOG5032ZBU; Bacteria.
DR   HOGENOM; CLU_158602_2_3_6; -.
DR   OMA; IQYPQGQ; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.30.1660.10; -; 1.
DR   InterPro; IPR025543; Dodecin-like.
DR   InterPro; IPR036275; YdgH-like_sf.
DR   InterPro; IPR010854; YdgH/BhsA/McbA-like_dom.
DR   Pfam; PF07338; DUF1471; 1.
DR   SUPFAM; SSF159871; SSF159871; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Copper; Membrane; Reference proteome; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..85
FT                   /note="Multiple stress resistance protein BhsA"
FT                   /id="PRO_0000042572"
SQ   SEQUENCE   85 AA;  8815 MW;  BB5122FE73E72181 CRC64;
     MKNVKTLIAA AILSSMSFAS FAAVEVQSTP EGQQKVGTIS ANAGTNLGSL EEQLAQKADE
     MGAKSFRITS VTGPNTLHGT AVIYK