ID   SLAP_LACHE              Reviewed;         439 AA.
AC   P38059;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 2.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=S-layer protein;
DE   AltName: Full=Surface layer protein;
DE   Flags: Precursor;
GN   Name=slpH;
OS   Lactobacillus helveticus (Lactobacillus suntoryeus).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lactobacillus.
OX   NCBI_TaxID=1587;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=CNRZ 1269, and CNRZ 892;
RA   Callegari M.L., Cocconcelli P.S., Morelli L.;
RL   Submitted (NOV-1995) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   PROTEIN SEQUENCE OF 31-53.
RC   STRAIN=ATCC 12046 / BCRC 12259 / JCM 1554 / NCIMB 8733 / H-80;
RA   Lortal S., van Heijenoort J., Gruber K., Sleytr U.B.;
RT   "S-layer of Lactobacillus helveticus ATCC 12046: isolation, chemical
RT   characterization and re-formation after extraction with lithium chloride.";
RL   J. Gen. Microbiol. 138:611-618(1992).
CC   -!- FUNCTION: The S-layer is a paracrystalline mono-layered assembly of
CC       proteins which coat the surface of bacteria.
CC   -!- SUBCELLULAR LOCATION: Secreted, cell wall, S-layer. Note=This bacterium
CC       is covered by a S-layer with hexagonal symmetry.
CC   -!- PTM: Glycosylated.
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DR   EMBL; X91199; CAA62606.1; -; Genomic_DNA.
DR   EMBL; X92752; CAA63409.1; -; Genomic_DNA.
DR   RefSeq; WP_023192974.1; NZ_JRQG01000020.1.
DR   AlphaFoldDB; P38059; -.
DR   ABCD; P38059; 1 sequenced antibody.
DR   GeneID; 66451426; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0009274; C:peptidoglycan-based cell wall; IEA:InterPro.
DR   GO; GO:0030115; C:S-layer; IEA:UniProtKB-SubCell.
DR   GO; GO:0005199; F:structural constituent of cell wall; IEA:InterPro.
DR   InterPro; IPR004903; S-layer_prot.
DR   InterPro; IPR024968; SlpA_dom.
DR   Pfam; PF03217; SlpA; 2.
DR   PIRSF; PIRSF037863; SLAP; 1.
DR   PRINTS; PR01729; SURFACELAYER.
PE   1: Evidence at protein level;
KW   Cell wall; Direct protein sequencing; Glycoprotein; S-layer; Secreted;
KW   Signal.
FT   SIGNAL          1..30
FT                   /evidence="ECO:0000269|Ref.2"
FT   CHAIN           31..439
FT                   /note="S-layer protein"
FT                   /id="PRO_0000032638"
FT   VARIANT         242
FT                   /note="Q -> P (in strain: CNRZ 1269)"
SQ   SEQUENCE   439 AA;  46688 MW;  54D7DD98B8113AB2 CRC64;
     MKKNLRIVSA AAAALLAVAP IAATAMPVNA ATTINADSAI NANTNAKYDV DVTPSISAIA
     AVAKSDTMPA IPGSLTGSIS ASYNGKSYTA NLPKDSGNAT ITDSNNNTVK PAELEADKAY
     TVTVPDVSFN FGSENAGKEI TIGSANPNVT FTEKTGDQPA STVKVTLDQD GVAKLSSVQI
     KNVYAIDTTY NSNVNFYDVT TGATVTTGAV SIDADNQGQL NITSVVAAIN SKYFAAQYDK
     KQLTNVTFDT ETAVKDALKA QKIEVSSVGY FKAPHTFTVN VKATSNKNGK SATLPVTVTV
     PNVADPVVPS QSKTIMHNAY FYDKDAKRVG TDKVTRYNTV TVAMNTTKLA NGISYYEVIE
     NGKATGKYIN ADNIDGTKRT LKHNAYVYKT SKKRANKVVL KKGTEVTTYG GSYKFKNGQR
     YYKIGANTEK TYVKVANFE