ID   SLAP_NIACI              Reviewed;        1616 AA.
AC   P35824;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=S-layer-related protein;
DE   Flags: Precursor;
GN   Name=butB;
OS   Niallia circulans (Bacillus circulans).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Niallia.
OX   NCBI_TaxID=1397;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=BCRC 11491 / NRRL B-3312;
RX   PubMed=7522196; DOI=10.1016/0378-1119(94)90032-9;
RA   Aubert-Pivert E., Davies J.;
RT   "Biosynthesis of butirosin in Bacillus circulans NRRL B3312: identification
RT   by sequence analysis and insertional mutagenesis of the butB gene involved
RT   in antibiotic production.";
RL   Gene 147:1-11(1994).
CC   -!- FUNCTION: The S-layer is a paracrystalline mono-layered assembly of
CC       proteins which coats the surface of bacteria. May play a role in the
CC       export of butirosin from the organism.
CC   -!- SUBCELLULAR LOCATION: Secreted, cell wall, S-layer. Note=This bacterium
CC       is covered by a S-layer with hexagonal symmetry.
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DR   EMBL; L20421; AAA62588.1; -; Genomic_DNA.
DR   PIR; T17884; T17884.
DR   AlphaFoldDB; P35824; -.
DR   PRIDE; P35824; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0030115; C:S-layer; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.60.40.10; -; 3.
DR   InterPro; IPR003343; Big_2.
DR   InterPro; IPR003790; GHL10.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR008964; Invasin/intimin_cell_adhesion.
DR   InterPro; IPR001119; SLH_dom.
DR   Pfam; PF02368; Big_2; 1.
DR   Pfam; PF02638; GHL10; 1.
DR   Pfam; PF00395; SLH; 1.
DR   SMART; SM00635; BID_2; 1.
DR   SUPFAM; SSF49373; SSF49373; 1.
DR   SUPFAM; SSF51445; SSF51445; 1.
DR   PROSITE; PS51272; SLH; 1.
PE   3: Inferred from homology;
KW   Cell wall; S-layer; Secreted; Signal.
FT   SIGNAL          1..30
FT                   /evidence="ECO:0000255"
FT   CHAIN           31..1616
FT                   /note="S-layer-related protein"
FT                   /id="PRO_0000032629"
FT   DOMAIN          1115..1185
FT                   /note="BIG2"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          1438..1502
FT                   /note="SLH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00777"
FT   REGION          1191..1244
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1372..1455
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1523..1554
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1585..1616
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1191..1217
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1228..1244
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1372..1387
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1532..1554
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1597..1616
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1616 AA;  172875 MW;  1F03FF7A4F113AA7 CRC64;
     MKSLLRKWNG MMIIALVISL LTPAWGKASA QSLGQESGGV QPQSAGVTDD VYVLSRDGTF
     RLPVGHINVN VDAPPQKTNY VALFTSGAQV TNSQETDKVF VKKTNTAIAV DKHDQVIRVI
     GPTAVPPTGS TWEENQNLPI PEGGYVLLAN DSSWGTSVTR KPLFEHYKTG DTVSLHKGGQ
     VVHAGDFLNP DPGLNLVTAS GTTVTSPDFT VSGQVVRYGS GQGISLTVNG TEAALKADGA
     FQSAVRLTAG TNAISVKLLK DGREIVSSTV TVTYNDAQQP ADLIEVEAAP IDITISIEGP
     AHAIGYVDQD IAGIDDTVAL FTNDWGPQIT VPQFNVAVQV DAGSKVTKVV NPSIDGKTPA
     WTGPTDLEIP SGGYVLVAQD TSYAGKNIKK YLATYFKVGD AIKLRKNGFA VPVKDLMGTG
     GPIARVTLDN YAMYTETKPS TELSGTITNM DDPSKIALTV NGTPLPFGPD GKFKTSYTLA
     EGINYLDLVV TKEGKEQDSK DLVVYSRPGF STGKKVILWV DQAANARKFQ TGDNVANFLR
     TAKENGVTSV VFDVKGVEGY VSYKKSTLTG RPYVSAIKAP EKAGSNPDLD LLQEFIRYSR
     ELGLDIHVSF NIFAEGSIAS NEFALLDSHL DWEERVYNAA DNGQIKRLRE SAKQGAVAFV
     NPSNDEVRDF QLKTIEEVLQ NYDVDGVVLD RARYDNESAD FSDLTKAKFE SFLGARGKQL
     QNWPDDVFTY AGNVRKDGPL IRDWWEFRSK TIKSFTSEVR QLTDRVKAEK GKKIEVSAYV
     GSWFESYYLN GVHWGSTEFR YDERLRMKDK SVYTPGYYES GYVKNLDFIM IGAYQTTAPE
     IEHYITLGNI VTNGEVPLYA GIALTNVQEP ALQRDVFQAG LVNTHGLMLF DASQVNWPVA
     GAALRNLVYV RDYQLGISLP DSPDSFLEGS YYNTNLIENN IGVLTDTFGY STGNSRFGVE
     AVVDSSGKVT SVPNKTQAMT WNWGKPDETN SVIPKGGFVV STLDASGIRT KRQLVANAYE
     TGDSVRAAAL SGFLAYEGLR TSADSVTFRG KVDVLGPGKA SVTVNGQEAA LREDGTFQAD
     TVIRPGANPV VIIVRVDGFK TNEKTVTIIG DEAAVKALKL DRGTYSMNKG ESLRLAVTAE
     YSSSSTDVTG QAAYASLDPA VVSVDATGRI TALREGSGTV QATYEGHTAT ARVSVTSGST
     GGGSDTGSGT GSGSGGGSAG GGGTAPSGPE RTSVTETKDS DGRNLTLVSA DAGVMEAEIA
     ALQGKAAPVL SYEIPGEEPA GIVSLPGTAL AKRFAGSPGA ILSVSSHLGA IELPAGLLEA
     DLPAVGSFDL LVQIGRTAAD ETADLRPGGE RRHAGTRHAG CFPCFAENRR RNKRNRRLRK
     LRPKNRKLAG SGRPLTAPRR WSWTRPPECS ASCPPASNRP GARRRPLSAT EAGGPTRWSP
     PRSASPTLHP TGRARMSSCW PRSIVDGMGA GGFSPDEALT RAQFAALLTR ALALDPAPAA
     ADFTDIPGDA WYAGAVARRS GPARGRFRNR GVPTRRGADT RTDERDAHAR REAGRYPDGG
     ELRCRCAGAL RGPGRNLRLG GRCRFAGGGS RPAGRTRGRT LRARPARLPV RKARPC