ID   BHSA_ECOL6              Reviewed;          85 AA.
AC   P0AB41; P75953;
DT   11-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Multiple stress resistance protein BhsA;
DE   AltName: Full=Copper-induced outer membrane component;
DE   Flags: Precursor;
GN   Name=bhsA; Synonyms=comC; OrderedLocusNames=c1386;
OS   Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=199310;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CFT073 / ATCC 700928 / UPEC;
RX   PubMed=12471157; DOI=10.1073/pnas.252529799;
RA   Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D.,
RA   Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F.,
RA   Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T.,
RA   Donnenberg M.S., Blattner F.R.;
RT   "Extensive mosaic structure revealed by the complete genome sequence of
RT   uropathogenic Escherichia coli.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
CC   -!- FUNCTION: Reduces the permeability of the outer membrane to copper. May
CC       be involved in the regulation of biofilm formation (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the BhsA/McbA family. {ECO:0000305}.
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DR   EMBL; AE014075; AAN79856.1; -; Genomic_DNA.
DR   RefSeq; WP_000800153.1; NC_004431.1.
DR   AlphaFoldDB; P0AB41; -.
DR   SMR; P0AB41; -.
DR   STRING; 199310.c1386; -.
DR   EnsemblBacteria; AAN79856; AAN79856; c1386.
DR   GeneID; 66670622; -.
DR   KEGG; ecc:c1386; -.
DR   eggNOG; ENOG5032ZBU; Bacteria.
DR   HOGENOM; CLU_158602_2_3_6; -.
DR   OMA; IQYPQGQ; -.
DR   BioCyc; ECOL199310:C1386-MON; -.
DR   Proteomes; UP000001410; Chromosome.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.30.1660.10; -; 1.
DR   InterPro; IPR025543; Dodecin-like.
DR   InterPro; IPR036275; YdgH-like_sf.
DR   InterPro; IPR010854; YdgH/BhsA/McbA-like_dom.
DR   Pfam; PF07338; DUF1471; 1.
DR   SUPFAM; SSF159871; SSF159871; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Copper; Membrane; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..85
FT                   /note="Multiple stress resistance protein BhsA"
FT                   /id="PRO_0000042571"
SQ   SEQUENCE   85 AA;  8815 MW;  BB5122FE73E72181 CRC64;
     MKNVKTLIAA AILSSMSFAS FAAVEVQSTP EGQQKVGTIS ANAGTNLGSL EEQLAQKADE
     MGAKSFRITS VTGPNTLHGT AVIYK