ID   SLA_OPHHA               Reviewed;          20 AA.
AC   P0C8J0;
DT   25-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT   25-NOV-2008, sequence version 1.
DT   25-MAY-2022, entry version 27.
DE   RecName: Full=Snaclec ophioluxin subunit alpha;
DE   Flags: Fragment;
OS   Ophiophagus hannah (King cobra) (Naja hannah).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX   NCBI_TaxID=8665;
RN   [1]
RP   PROTEIN SEQUENCE, AND FUNCTION.
RC   TISSUE=Venom;
RX   PubMed=12130642; DOI=10.1074/jbc.m204372200;
RA   Du X.-Y., Clemetson J.M., Navdaev A., Magnenat E.M., Wells T.N.C.,
RA   Clemetson K.J.;
RT   "Ophioluxin, a convulxin-like C-type lectin from Ophiophagus hannah (King
RT   cobra) is a powerful platelet activator via glycoprotein VI.";
RL   J. Biol. Chem. 277:35124-35132(2002).
CC   -!- FUNCTION: Binds to the platelet and collagen receptor glycoprotein VI
CC       (GP6) and activates platelet aggregation.
CC       {ECO:0000269|PubMed:12130642}.
CC   -!- SUBUNIT: Heterodimer of subunits alpha and beta; disulfide-linked.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- MISCELLANEOUS: Does not agglutinate fixed platelets.
CC       {ECO:0000305|PubMed:12130642}.
CC   -!- SIMILARITY: Belongs to the snaclec family. {ECO:0000305}.
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DR   AlphaFoldDB; P0C8J0; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Hemostasis impairing toxin;
KW   Platelet aggregation activating toxin; Secreted; Toxin.
FT   CHAIN           1..>20
FT                   /note="Snaclec ophioluxin subunit alpha"
FT                   /id="PRO_0000355283"
FT   DOMAIN          11..>20
FT                   /note="C-type lectin"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT   DISULFID        4..15
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT   NON_TER         20
SQ   SEQUENCE   20 AA;  2552 MW;  AA91F569B400E66C CRC64;
     DFKCPSEWYA YDQHCYRIIN