ID   SLA_PROTO               Reviewed;          40 AA.
AC   Q7LZK6;
DT   25-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   25-MAY-2022, entry version 53.
DE   RecName: Full=Snaclec tokaracetin subunit alpha;
DE   Flags: Fragment;
OS   Protobothrops tokarensis (Tokara habu) (Trimeresurus tokarensis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Viperidae; Crotalinae; Protobothrops.
OX   NCBI_TaxID=61225;
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, AND SUBUNIT.
RC   TISSUE=Venom;
RX   PubMed=8948455; DOI=10.1042/bj3080947;
RA   Kawasaki T., Taniuchi Y., Hisamichi N., Fujimura Y., Suzuki M., Titani K.,
RA   Sakai Y., Kaku S., Satoh N., Takenaka T., Handa M., Sawai Y.;
RT   "Tokaracetin, a new platelet antagonist that binds to platelet glycoprotein
RT   Ib and inhibits von Willebrand factor-dependent shear-induced platelet
RT   aggregation.";
RL   Biochem. J. 308:947-953(1995).
CC   -!- FUNCTION: Platelet antagonist that specifically and reversibly binds to
CC       a site on platelet glycoprotein Ibalpha (GP1BA) close to or identical
CC       with the site for vWF binding. It inhibits the binding of vWF to
CC       platelets and vWF-dependent shear-induced platelet aggregation.
CC       {ECO:0000269|PubMed:8948455}.
CC   -!- SUBUNIT: Heterodimer of subunits alpha and beta; disulfide-linked.
CC       {ECO:0000269|PubMed:8948455}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- SIMILARITY: Belongs to the snaclec family. {ECO:0000305}.
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DR   PIR; S56006; S56006.
DR   AlphaFoldDB; Q7LZK6; -.
DR   SMR; Q7LZK6; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.10.100.10; -; 1.
DR   InterPro; IPR016186; C-type_lectin-like/link_sf.
DR   InterPro; IPR016187; CTDL_fold.
DR   SUPFAM; SSF56436; SSF56436; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Hemostasis impairing toxin;
KW   Platelet aggregation inhibiting toxin; Secreted; Toxin.
FT   CHAIN           1..>40
FT                   /note="Snaclec tokaracetin subunit alpha"
FT                   /id="PRO_0000355287"
FT   DOMAIN          1..>40
FT                   /note="C-type lectin"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT   DISULFID        2..13
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT   NON_TER         40
SQ   SEQUENCE   40 AA;  4754 MW;  AF556281421D5DD8 CRC64;
     DCPSGWSSFK QYCYKPFKQL KTWEDAERFC LEQVKGAHLV