ID   SLA_TROWA               Reviewed;           9 AA.
AC   P0DMM6;
DT   03-SEP-2014, integrated into UniProtKB/Swiss-Prot.
DT   03-SEP-2014, sequence version 1.
DT   26-FEB-2020, entry version 8.
DE   RecName: Full=Snaclec trowaglerix subunit alpha;
DE   Flags: Fragment;
OS   Tropidolaemus wagleri (Wagler's pit viper) (Trimeresurus wagleri).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Viperidae; Crotalinae; Tropidolaemus.
OX   NCBI_TaxID=8770;
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, SUBUNIT, AND MASS SPECTROMETRY.
RC   TISSUE=Venom;
RX   PubMed=18221359; DOI=10.1111/j.1538-7836.2008.02914.x;
RA   Chang C.H., Chung C.H., Kuo H.L., Hsu C.C., Huang T.F.;
RT   "The highly specific platelet glycoprotein (GP) VI agonist trowaglerix
RT   impaired collagen-induced platelet aggregation ex vivo through matrix
RT   metalloproteinase-dependent GPVI shedding.";
RL   J. Thromb. Haemost. 6:669-676(2008).
CC   -!- FUNCTION: Potently induces platelet aggregation of washed human
CC       platelet and platelet-rich plasma in a concentration-dependent manner.
CC       It acts by binding to GPVI (GP6), leading to kinases-dependent exposure
CC       of functional alpha-IIb/beta-3 and platelet aggregation, and also
CC       induces metalloproteinase-dependent GP6 shedding from platelets.
CC       {ECO:0000269|PubMed:18221359}.
CC   -!- SUBUNIT: Hexamer of heterodimers of subunits alpha and beta
CC       (alphabeta)(6); disulfide-linked. {ECO:0000269|PubMed:18221359}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- MASS SPECTROMETRY: Mass=16700; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:18221359};
CC   -!- MISCELLANEOUS: Does not bind to GPIb and alpha-2 integrin. Does not
CC       agglutinate the formalin-fixed platelets, even at high concentrations
CC       (PubMed:18221359). {ECO:0000305|PubMed:18221359}.
CC   -!- SIMILARITY: Belongs to the snaclec family. {ECO:0000305}.
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DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Hemostasis impairing toxin;
KW   Platelet aggregation activating toxin; Secreted; Toxin.
FT   CHAIN           1..>9
FT                   /note="Snaclec trowaglerix subunit alpha"
FT                   /id="PRO_0000430180"
FT   DISULFID        3..?
FT   NON_TER         9
SQ   SEQUENCE   9 AA;  1279 MW;  52B5437B05B69EB3 CRC64;
     FKCMSEWYW