ID   BHUA_BRUAB              Reviewed;         661 AA.
AC   Q576D7;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Heme transporter BhuA;
DE   Flags: Precursor;
GN   Name=bhuA; OrderedLocusNames=BruAb2_1126;
OS   Brucella abortus biovar 1 (strain 9-941).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX   NCBI_TaxID=262698;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=9-941;
RX   PubMed=15805518; DOI=10.1128/jb.187.8.2715-2726.2005;
RA   Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z.,
RA   Li L.-L., Kapur V., Alt D.P., Olsen S.C.;
RT   "Completion of the genome sequence of Brucella abortus and comparison to
RT   the highly similar genomes of Brucella melitensis and Brucella suis.";
RL   J. Bacteriol. 187:2715-2726(2005).
CC   -!- FUNCTION: Heme transporter. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000250}.
CC   -!- INDUCTION: Induced in absence of iron. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TonB-dependent receptor family.
CC       {ECO:0000305}.
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DR   EMBL; AE017224; AAX76497.1; -; Genomic_DNA.
DR   RefSeq; WP_002966591.1; NC_006933.1.
DR   AlphaFoldDB; Q576D7; -.
DR   SMR; Q576D7; -.
DR   EnsemblBacteria; AAX76497; AAX76497; BruAb2_1126.
DR   KEGG; bmb:BruAb2_1126; -.
DR   HOGENOM; CLU_008287_19_4_5; -.
DR   OMA; KFMDESA; -.
DR   Proteomes; UP000000540; Chromosome II.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 2.170.130.10; -; 1.
DR   Gene3D; 2.40.170.20; -; 1.
DR   InterPro; IPR039426; BtuB-like.
DR   InterPro; IPR012910; Plug_dom.
DR   InterPro; IPR037066; Plug_dom_sf.
DR   InterPro; IPR000531; TonB-dep_rcpt_b-brl.
DR   InterPro; IPR036942; TonB_rcpt_b-brl_sf.
DR   PANTHER; PTHR30069; PTHR30069; 1.
DR   Pfam; PF07715; Plug; 1.
DR   Pfam; PF00593; TonB_dep_Rec; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Membrane; Receptor; Signal; TonB box; Transmembrane;
KW   Transmembrane beta strand.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..661
FT                   /note="Heme transporter BhuA"
FT                   /id="PRO_0000325856"
SQ   SEQUENCE   661 AA;  72903 MW;  77A68704B28FE01F CRC64;
     MKFTRTLVLA STSLLATVAT SQAQEVKRDT KKQGEVVLKP ITIISHGKDN IEATGGTVLT
     YKDIEKLQPA NVSELFSRQS SIAVSGGGGP SKRIHVLGME QSNLAVSVDG VPQTATSWHH
     TGSNVIDPAF LKRVEVEAGA AAADSGFGAA AGAIRYETVN ALDLLEPGKT FGARIIGSYG
     TNGRGFSGST AAYGLKDGFD WLLMLHGTSG HNYKNGDGTE ILGTEPAARN ILGKAGYEFD
     GNRIDIGYER SRDKADRLIK MNMGLPGDTE YPLEVARDSV NIKYTRTDAT DMWDPEVQFY
     YNRNDYWRND YQNRTNGNMI LKEDLYGGKL QNTFTIDYGK ITAGIDFGKH DYNTDNYGHN
     DRRYRKFNTQ QVGAFTQGRF EFDNGFSLST GARYDYSRFA DWNDEVFSDS GASVNGTLSY
     KFNEHIEVFA GASRTWLGYV LGDYGYVHAR NNAFYTDPTF SPGRARNYKA GVNFGGADWS
     AGITLFDTRI AGLPNYDSQK LGNDPEEYRS RGFTLNARYI WNYTTIGATF TKAKVTAGDD
     PVLPNSGSFM PIGDMATLFI DQEIPDYNMK VGATLAWAGR ISDEAATAAN FYDQPAYTVV
     NAYAEWNPPA VKNMTLRVGV ENLFNENYYE RTSFAPSQNR GGIDAVWAPG RTFTFQTAFK
     F