SLBP_CAEEL
ID SLBP_CAEEL Reviewed; 367 AA.
AC Q09599;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Histone RNA hairpin-binding protein;
DE AltName: Full=Histone stem-loop-binding protein;
GN Name=cdl-1; ORFNames=R06F6.1;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=9049306; DOI=10.1093/emboj/16.4.769;
RA Martin F., Schaller A., Eglite S., Schuemperli D., Mueller B.;
RT "The gene for histone RNA hairpin binding protein is located on human
RT chromosome 4 and encodes a novel type of RNA binding protein.";
RL EMBO J. 16:769-778(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RC STRAIN=Bristol N2;
RX PubMed=11782412; DOI=10.1242/dev.129.1.187;
RA Kodama Y., Rothman J.H., Sugimoto A., Yamamoto M.;
RT "The stem-loop binding protein CDL-1 is required for chromosome
RT condensation, progression of cell death and morphogenesis in Caenorhabditis
RT elegans.";
RL Development 129:187-196(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [4]
RP UBIQUITINATION.
RX PubMed=28118078; DOI=10.1080/15384101.2017.1284715;
RA Dankert J.F., Pagan J.K., Starostina N.G., Kipreos E.T., Pagano M.;
RT "FEM1 proteins are ancient regulators of SLBP degradation.";
RL Cell Cycle 16:556-564(2017).
CC -!- FUNCTION: Involved in histone pre-mRNA 3' processing (PubMed:11782412).
CC Required for chromosome condensation, progression of cell death and
CC morphogenesis (PubMed:11782412). {ECO:0000269|PubMed:11782412}.
CC -!- PTM: Ubiquitinated by the CBC(fem-1) (Cul2-ElonginB-ElonginC) E3
CC ubiquitin-protein ligase complex, leading to its degradation.
CC {ECO:0000269|PubMed:28118078}.
CC -!- SIMILARITY: Belongs to the SLBP family. {ECO:0000305}.
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DR EMBL; Y10114; CAA71200.1; -; mRNA.
DR EMBL; AB060649; BAB83255.1; -; mRNA.
DR EMBL; Z46794; CAA86782.1; -; Genomic_DNA.
DR PIR; T23983; T23983.
DR RefSeq; NP_496320.4; NM_063919.7.
DR AlphaFoldDB; Q09599; -.
DR SMR; Q09599; -.
DR BioGRID; 39972; 5.
DR IntAct; Q09599; 2.
DR STRING; 6239.R06F6.1; -.
DR iPTMnet; Q09599; -.
DR EPD; Q09599; -.
DR PaxDb; Q09599; -.
DR PeptideAtlas; Q09599; -.
DR EnsemblMetazoa; R06F6.1.1; R06F6.1.1; WBGene00000411.
DR GeneID; 174659; -.
DR KEGG; cel:CELE_R06F6.1; -.
DR UCSC; R06F6.1.1; c. elegans.
DR CTD; 174659; -.
DR WormBase; R06F6.1; CE51537; WBGene00000411; cdl-1.
DR eggNOG; KOG3934; Eukaryota.
DR GeneTree; ENSGT00940000170890; -.
DR HOGENOM; CLU_724098_0_0_1; -.
DR InParanoid; Q09599; -.
DR OMA; EYCGEEP; -.
DR OrthoDB; 1039552at2759; -.
DR Reactome; R-CEL-159230; Transport of the SLBP Dependant Mature mRNA.
DR Reactome; R-CEL-73856; RNA Polymerase II Transcription Termination.
DR Reactome; R-CEL-77588; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs.
DR PRO; PR:Q09599; -.
DR Proteomes; UP000001940; Chromosome II.
DR Bgee; WBGene00000411; Expressed in embryo and 4 other tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0071204; C:histone pre-mRNA 3'end processing complex; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; TAS:WormBase.
DR GO; GO:0071207; F:histone pre-mRNA stem-loop binding; IBA:GO_Central.
DR GO; GO:0003730; F:mRNA 3'-UTR binding; IDA:WormBase.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0006915; P:apoptotic process; IMP:WormBase.
DR GO; GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.
DR GO; GO:0007076; P:mitotic chromosome condensation; IMP:WormBase.
DR GO; GO:0006398; P:mRNA 3'-end processing by stem-loop binding and cleavage; IBA:GO_Central.
DR GO; GO:0051028; P:mRNA transport; IBA:GO_Central.
DR Gene3D; 1.10.8.1120; -; 1.
DR InterPro; IPR026502; SLBP1/SLBP2.
DR InterPro; IPR029344; SLBP_RNA_bind.
DR InterPro; IPR038294; SLBP_RNA_bind_sf.
DR PANTHER; PTHR17408; PTHR17408; 1.
DR Pfam; PF15247; SLBP_RNA_bind; 1.
PE 1: Evidence at protein level;
KW mRNA processing; Reference proteome; RNA-binding; Ubl conjugation.
FT CHAIN 1..367
FT /note="Histone RNA hairpin-binding protein"
FT /id="PRO_0000100360"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 49..200
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 206..275
FT /note="RNA-binding"
FT /evidence="ECO:0000250"
FT REGION 342..367
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 49..77
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 78..108
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 124..158
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 343..367
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 367 AA; 41481 MW; F5E4EFF4E7B01FBE CRC64;
MAQKTPTKGT RSSPRKKAWG SPIKATAKFQ SDIFSVEDFA DLSNRSWAEV TEEDDELASR
LEEERRCKSE SRRKGQPKRA QNSQNKPKFV RSLELTNEVF QSTSSRRSQR SKSRTRNGDT
ITTVEEHTET VVMESSSGPI SRKRCLSNAS TINEGASPSK RRPETGKSNR KAPRGRLFTN
GGSDSSSVAS SPSRRDHWEE PTLGWCTDEA VLKRRSREID RAKEKAVYQR YTSEVPLRDR
IKGQHPRTPN KLINFSRRSW DTQIKKWKRS LYEYCGEEPS DSVNTSFCYS DSDALSEAGD
NDKEIENRSV LRDLVIPVTM RPEVDSMASL LGKFDVDSQM GMDESTLKAS TNTDPSAPTD
FSKMSSH
