ID   BHUA_BRUO2              Reviewed;         661 AA.
AC   A5VW32;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   18-MAR-2008, sequence version 2.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Heme transporter BhuA;
DE   Flags: Precursor;
GN   Name=bhuA; OrderedLocusNames=BOV_A1093;
OS   Brucella ovis (strain ATCC 25840 / 63/290 / NCTC 10512).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX   NCBI_TaxID=444178;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25840 / 63/290 / NCTC 10512;
RX   PubMed=19436743; DOI=10.1371/journal.pone.0005519;
RA   Tsolis R.M., Seshadri R., Santos R.L., Sangari F.J., Lobo J.M.,
RA   de Jong M.F., Ren Q., Myers G., Brinkac L.M., Nelson W.C., Deboy R.T.,
RA   Angiuoli S., Khouri H., Dimitrov G., Robinson J.R., Mulligan S.,
RA   Walker R.L., Elzer P.E., Hassan K.A., Paulsen I.T.;
RT   "Genome degradation in Brucella ovis corresponds with narrowing of its host
RT   range and tissue tropism.";
RL   PLoS ONE 4:E5519-E5519(2009).
CC   -!- FUNCTION: Heme transporter. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000250}.
CC   -!- INDUCTION: Induced in absence of iron. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TonB-dependent receptor family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABQ62341.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CP000709; ABQ62341.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_006014867.1; NC_009504.1.
DR   AlphaFoldDB; A5VW32; -.
DR   SMR; A5VW32; -.
DR   EnsemblBacteria; ABQ62341; ABQ62341; BOV_A1093.
DR   GeneID; 45126449; -.
DR   KEGG; bov:BOV_A1093; -.
DR   HOGENOM; CLU_008287_19_4_5; -.
DR   PhylomeDB; A5VW32; -.
DR   Proteomes; UP000006383; Chromosome II.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 2.170.130.10; -; 1.
DR   Gene3D; 2.40.170.20; -; 1.
DR   InterPro; IPR039426; BtuB-like.
DR   InterPro; IPR012910; Plug_dom.
DR   InterPro; IPR037066; Plug_dom_sf.
DR   InterPro; IPR000531; TonB-dep_rcpt_b-brl.
DR   InterPro; IPR036942; TonB_rcpt_b-brl_sf.
DR   PANTHER; PTHR30069; PTHR30069; 1.
DR   Pfam; PF07715; Plug; 1.
DR   Pfam; PF00593; TonB_dep_Rec; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Membrane; Receptor; Signal; TonB box; Transmembrane;
KW   Transmembrane beta strand.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..661
FT                   /note="Heme transporter BhuA"
FT                   /id="PRO_0000325859"
SQ   SEQUENCE   661 AA;  72895 MW;  2F2AF672EE7C2D03 CRC64;
     MKFTRTLVLA STSLLATVAT SQAQEVKRDT KKQGEVVLKP ITIISHGKDN IEATGGTVLT
     YKDIEKLQPA NVSELFSRQS SIAVSGGGGP SKRIHVLGME QSNLAVSVDG VPQTATSWHH
     TGSNVIDPAF LKRVEVEAGA AAADSGFGAA AGAIRYETVN ALDLLEPGKT FGARIIGSYG
     TNGRGFSGST AAYGLKDGFD WLLMLHGTSG HNYKNGDGTE ILGTEPAARN ILGKAGYEFD
     GNRIDIGYER SRDKADRLIK MNMGLPGDTE YPLEVARDSV NIKYTRTDAT DMWDPEVQLY
     YNRNDYWRND YQNRTNGNMI LKEDLYGGKL QNTFTIDYGK ITAGIDFGKH DYNTDNYGHN
     DRRYRKFNTQ QVGAFTQGRF EFDNGFSLST GARYDYSRFA DWNDEVFSDS GASVNGTLSY
     KFNEHIEVFA GASRTWLGYV LGDYGYVHAR NNAFYTDPTF SPGRARNYKA GVNFGGADWS
     AGITLFDTRI AGLPNYDSQK LGNDPEEYRS RGFTLNARYI WNYTTIGATF TKAKVTAGDD
     PVLPNSGSFM PIGDMATLFI DQEIPDYNMK VGATLAWAGR ISDEAATAAN FYDQPAYTVV
     NAYAEWNPPA VKNMTLRVGV ENLFNENYYE RTSFAPSQNR GGIDPVWAPG RTFTFQTAFK
     F