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SLB_OPHHA
ID   SLB_OPHHA               Reviewed;          13 AA.
AC   P0C8J1;
DT   25-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT   25-NOV-2008, sequence version 1.
DT   26-FEB-2020, entry version 21.
DE   RecName: Full=Snaclec ophioluxin subunit beta;
DE   Flags: Fragment;
OS   Ophiophagus hannah (King cobra) (Naja hannah).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX   NCBI_TaxID=8665;
RN   [1]
RP   PROTEIN SEQUENCE, AND FUNCTION.
RC   TISSUE=Venom;
RX   PubMed=12130642; DOI=10.1074/jbc.m204372200;
RA   Du X.-Y., Clemetson J.M., Navdaev A., Magnenat E.M., Wells T.N.C.,
RA   Clemetson K.J.;
RT   "Ophioluxin, a convulxin-like C-type lectin from Ophiophagus hannah (King
RT   cobra) is a powerful platelet activator via glycoprotein VI.";
RL   J. Biol. Chem. 277:35124-35132(2002).
CC   -!- FUNCTION: Binds to the platelet and collagen receptor glycoprotein VI
CC       (GP6) and activates platelet aggregation.
CC       {ECO:0000269|PubMed:12130642}.
CC   -!- SUBUNIT: Heterodimer of subunits alpha and beta; disulfide-linked.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- PTM: May be glycosylated.
CC   -!- MISCELLANEOUS: Does not agglutinate fixed platelets.
CC       {ECO:0000305|PubMed:12130642}.
CC   -!- SIMILARITY: Belongs to the snaclec family. {ECO:0000305}.
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DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Glycoprotein;
KW   Hemostasis impairing toxin; Platelet aggregation activating toxin;
KW   Secreted; Toxin.
FT   CHAIN           1..>13
FT                   /note="Snaclec ophioluxin subunit beta"
FT                   /id="PRO_0000355284"
FT   DOMAIN          11..>13
FT                   /note="C-type lectin"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT   NON_TER         13
SQ   SEQUENCE   13 AA;  1413 MW;  B439D8748E386406 CRC64;
     GLCCPMRWSS SEG
 
 
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