SLB_OPHHA
ID SLB_OPHHA Reviewed; 13 AA.
AC P0C8J1;
DT 25-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT 25-NOV-2008, sequence version 1.
DT 26-FEB-2020, entry version 21.
DE RecName: Full=Snaclec ophioluxin subunit beta;
DE Flags: Fragment;
OS Ophiophagus hannah (King cobra) (Naja hannah).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX NCBI_TaxID=8665;
RN [1]
RP PROTEIN SEQUENCE, AND FUNCTION.
RC TISSUE=Venom;
RX PubMed=12130642; DOI=10.1074/jbc.m204372200;
RA Du X.-Y., Clemetson J.M., Navdaev A., Magnenat E.M., Wells T.N.C.,
RA Clemetson K.J.;
RT "Ophioluxin, a convulxin-like C-type lectin from Ophiophagus hannah (King
RT cobra) is a powerful platelet activator via glycoprotein VI.";
RL J. Biol. Chem. 277:35124-35132(2002).
CC -!- FUNCTION: Binds to the platelet and collagen receptor glycoprotein VI
CC (GP6) and activates platelet aggregation.
CC {ECO:0000269|PubMed:12130642}.
CC -!- SUBUNIT: Heterodimer of subunits alpha and beta; disulfide-linked.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC -!- PTM: May be glycosylated.
CC -!- MISCELLANEOUS: Does not agglutinate fixed platelets.
CC {ECO:0000305|PubMed:12130642}.
CC -!- SIMILARITY: Belongs to the snaclec family. {ECO:0000305}.
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DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Disulfide bond; Glycoprotein;
KW Hemostasis impairing toxin; Platelet aggregation activating toxin;
KW Secreted; Toxin.
FT CHAIN 1..>13
FT /note="Snaclec ophioluxin subunit beta"
FT /id="PRO_0000355284"
FT DOMAIN 11..>13
FT /note="C-type lectin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT NON_TER 13
SQ SEQUENCE 13 AA; 1413 MW; B439D8748E386406 CRC64;
GLCCPMRWSS SEG