ID   SLD2_ASHGO              Reviewed;         379 AA.
AC   Q75DR2;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=DNA replication regulator SLD2;
GN   Name=SLD2; OrderedLocusNames=ABL045W;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Has a role in the initiation of DNA replication. Required at
CC       S-phase checkpoint (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SLD2 family. {ECO:0000305}.
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DR   EMBL; AE016815; AAS50726.1; -; Genomic_DNA.
DR   RefSeq; NP_982902.1; NM_208255.1.
DR   AlphaFoldDB; Q75DR2; -.
DR   SMR; Q75DR2; -.
DR   STRING; 33169.AAS50726; -.
DR   EnsemblFungi; AAS50726; AAS50726; AGOS_ABL045W.
DR   GeneID; 4618985; -.
DR   KEGG; ago:AGOS_ABL045W; -.
DR   eggNOG; ENOG502SCF7; Eukaryota.
DR   HOGENOM; CLU_057728_0_0_1; -.
DR   InParanoid; Q75DR2; -.
DR   OMA; GPTPQIY; -.
DR   Proteomes; UP000000591; Chromosome II.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0031261; C:DNA replication preinitiation complex; IBA:GO_Central.
DR   GO; GO:0003688; F:DNA replication origin binding; IBA:GO_Central.
DR   GO; GO:0003697; F:single-stranded DNA binding; IBA:GO_Central.
DR   GO; GO:0006270; P:DNA replication initiation; IBA:GO_Central.
DR   GO; GO:0000727; P:double-strand break repair via break-induced replication; IBA:GO_Central.
DR   GO; GO:0033314; P:mitotic DNA replication checkpoint signaling; IEA:EnsemblFungi.
DR   GO; GO:1902977; P:mitotic DNA replication preinitiation complex assembly; IBA:GO_Central.
DR   GO; GO:0031333; P:negative regulation of protein-containing complex assembly; IEA:EnsemblFungi.
DR   InterPro; IPR021110; DNA_rep_checkpnt_protein.
DR   InterPro; IPR040203; Sld2.
DR   PANTHER; PTHR28124; PTHR28124; 1.
DR   Pfam; PF11719; Drc1-Sld2; 2.
PE   3: Inferred from homology;
KW   Cell cycle; Cytoplasm; DNA replication; Nucleus; Reference proteome.
FT   CHAIN           1..379
FT                   /note="DNA replication regulator SLD2"
FT                   /id="PRO_0000278428"
FT   REGION          60..79
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          263..292
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          322..379
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        63..77
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        264..278
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        322..343
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   379 AA;  42509 MW;  C7C4881F2CA314C8 CRC64;
     MSRTSAGELD VLKVQLKTWE RQFLEENGRS PIKEDIKAHP EIRRKYKEYT SLKKLLSKGN
     AAVTGQKHGS PSRATHPTPQ KHIDAEIELG PTPQIYGKVV SLFEMHISPL KKVPVRQLDA
     DSSETCISPD LHSQDVAQSE LLTDISCQAK RQLDFSVTPH ASPVKAVQPL LLNAPDLRFE
     AIPHARTKYG PNSPVKFDGD VTLTLSQTPL QAKLAQASEG YSPSPLIKRP AKPLSQLAKE
     YEDIVEELKE VDHAAAVRNL GGLLQQEEEN TQEAEAAEPS ATRSDRKRRK NKVRPALVTL
     EEEIPQGNLH EQLVKLRQKA LDKFNGNDPN DSSDEEKKTS ATSAKPAKAR KRKYNTVSDN
     FRRLKLPTKN TRNGRWRRR