SLD2_ASPFU
ID SLD2_ASPFU Reviewed; 535 AA.
AC Q4WXD3;
DT 20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2005, sequence version 1.
DT 25-MAY-2022, entry version 73.
DE RecName: Full=DNA replication regulator sld2;
GN Name=sld2; ORFNames=AFUA_3G09100;
OS Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS A1100) (Aspergillus fumigatus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=330879;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX PubMed=16372009; DOI=10.1038/nature04332;
RA Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA Barrell B.G., Denning D.W.;
RT "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT Aspergillus fumigatus.";
RL Nature 438:1151-1156(2005).
CC -!- FUNCTION: Has a role in the initiation of DNA replication. Required at
CC S-phase checkpoint (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SLD2 family. {ECO:0000305}.
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DR EMBL; AAHF01000002; EAL92670.1; -; Genomic_DNA.
DR RefSeq; XP_754708.1; XM_749615.1.
DR AlphaFoldDB; Q4WXD3; -.
DR SMR; Q4WXD3; -.
DR STRING; 746128.CADAFUBP00003920; -.
DR PRIDE; Q4WXD3; -.
DR EnsemblFungi; EAL92670; EAL92670; AFUA_3G09100.
DR GeneID; 3511945; -.
DR KEGG; afm:AFUA_3G09100; -.
DR VEuPathDB; FungiDB:Afu3g09100; -.
DR eggNOG; ENOG502SCF7; Eukaryota.
DR HOGENOM; CLU_033089_0_0_1; -.
DR InParanoid; Q4WXD3; -.
DR OMA; EAHANYR; -.
DR OrthoDB; 1077953at2759; -.
DR Proteomes; UP000002530; Chromosome 3.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0031261; C:DNA replication preinitiation complex; IBA:GO_Central.
DR GO; GO:0003688; F:DNA replication origin binding; IBA:GO_Central.
DR GO; GO:0003697; F:single-stranded DNA binding; IBA:GO_Central.
DR GO; GO:0006270; P:DNA replication initiation; IBA:GO_Central.
DR GO; GO:0000727; P:double-strand break repair via break-induced replication; IBA:GO_Central.
DR GO; GO:1902977; P:mitotic DNA replication preinitiation complex assembly; IBA:GO_Central.
DR InterPro; IPR021110; DNA_rep_checkpnt_protein.
DR InterPro; IPR040203; Sld2.
DR PANTHER; PTHR28124; PTHR28124; 1.
DR Pfam; PF11719; Drc1-Sld2; 1.
PE 3: Inferred from homology;
KW Cell cycle; Cytoplasm; DNA replication; Nucleus; Reference proteome.
FT CHAIN 1..535
FT /note="DNA replication regulator sld2"
FT /id="PRO_0000278429"
FT REGION 58..156
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 170..221
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 249..302
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 358..535
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 71..89
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 91..125
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 133..147
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 275..295
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 361..375
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 436..469
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 489..511
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 518..535
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 535 AA; 58919 MW; 5081B845F04D45E6 CRC64;
MASVAISEIV TQSANLRAEL KEWERAFAAQ NGGRKAERKD IKKVPEIAAK YKEYSRLKAL
ESSSPNPDDP KSVQLEERPK KRKRAFKDGP DAIQNSSTPR KTAKGALETP SKNRLSSSHP
SQVDPYISPT ALRRLFSPST HRTPLKTAIG PTPQRDGKAL GLFDLLSESG GSTATPSADR
VASVRAANVR TPSKRKTMDT IMEEDEDGEE ESPRLGRTPA SSGKKWMLSA LFATPTTLRY
SAMVEDGNHI TERNLGPPTD PEGTARDVAG PETPSFLRRS NSARYATSHS ANPSLSPIAV
RKPPQFVGKG LSALVQGLRD MEEERLEDDL DVLREIEAEQ AALNVEVADS QAPAEIIGRH
WKKKGQKRTT RRVRMKPVIS KPASKPQSAS DDENRHQAAG EEPAEPAAVP ETQQPRALDA
VFSEKQNEEF DDEDDQVSLH TISEPDLDSD PEYGEDIKPV TKSKSFSEKM KEAIGVAQPQ
PTEDPAKPSK PVIEAEETKK VRARKVNPEA HANYRSLKIR NKNSKGRGAG RFRRR
