ID   SLD2_ASPOR              Reviewed;         527 AA.
AC   Q2UQ97;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=DNA replication regulator sld2;
GN   Name=sld2; ORFNames=AO090005001340;
OS   Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=510516;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 42149 / RIB 40;
RX   PubMed=16372010; DOI=10.1038/nature04300;
RA   Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K.,
RA   Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H.,
RA   Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.,
RA   Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D.,
RA   Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A.,
RA   Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y.,
RA   Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H.,
RA   Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T.,
RA   Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O.,
RA   Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y.,
RA   Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N.,
RA   Kikuchi H.;
RT   "Genome sequencing and analysis of Aspergillus oryzae.";
RL   Nature 438:1157-1161(2005).
CC   -!- FUNCTION: Has a role in the initiation of DNA replication. Required at
CC       S-phase checkpoint (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SLD2 family. {ECO:0000305}.
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DR   EMBL; AP007151; BAE56268.1; -; Genomic_DNA.
DR   RefSeq; XP_001818270.2; XM_001818218.2.
DR   AlphaFoldDB; Q2UQ97; -.
DR   SMR; Q2UQ97; -.
DR   STRING; 510516.Q2UQ97; -.
DR   EnsemblFungi; BAE56268; BAE56268; AO090005001340.
DR   GeneID; 5990215; -.
DR   KEGG; aor:AO090005001340; -.
DR   VEuPathDB; FungiDB:AO090005001340; -.
DR   HOGENOM; CLU_033089_0_0_1; -.
DR   OMA; EAHANYR; -.
DR   Proteomes; UP000006564; Chromosome 1.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR   InterPro; IPR021110; DNA_rep_checkpnt_protein.
DR   InterPro; IPR040203; Sld2.
DR   PANTHER; PTHR28124; PTHR28124; 1.
DR   Pfam; PF11719; Drc1-Sld2; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cytoplasm; DNA replication; Nucleus; Reference proteome.
FT   CHAIN           1..527
FT                   /note="DNA replication regulator sld2"
FT                   /id="PRO_0000278430"
FT   REGION          60..226
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          244..303
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          340..527
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        60..101
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        132..151
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        253..267
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        275..295
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        343..357
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        445..464
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        477..502
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        509..527
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   527 AA;  57971 MW;  0E8BEA0451656DFC CRC64;
     MASLDVSDIA AQSAQLRAEL KEWERAFAAA NEGRKAERSD IKQAPEIAAK YKEYSRLKSL
     EKSVRYEKKH NPNSVNLEER PKKRKHASPP GSHEARLEST PRKAAKGPFT TPSKPRGHPS
     EFDPYDSPSA LRRLFSPSTH QQSSSPLKTA IGPTPQRDGK ALGLFDLLSE SGGSTATPTA
     ARLASVRGAA AQTPSKRKTL DTIAEEEEEE DGPRGDRTPA SASKSYMLSA LFATPTTWRY
     ATMMDNRNDA IRREPSPQPS ANDAGQGAPE SETPAFLRRS NSARYAASNP NGEGLSPINV
     RKRPRFVGKG LSALVQGLRD MEEEHLDNEL DVLREIEAEQ AGMNTEATDS QAVEQDTVPT
     FKKKGQKRTT RRVRMKPVIS KPKCESQLPA SEDEDNTDNV DQSDDELAAV PETQQPGASG
     DETNGVPDAA SLHSISEPEL DSDSDYEEQS KPPARSKSFS ERIRDAIGVV EPPPAEKQEK
     PQPKVKEKQT KPRERKVNPE AHANYRSLKL RNKNSKGRGA GRFGRRR