ID   SLD2_CANAL              Reviewed;         354 AA.
AC   Q59UH5; A0A1D8PSF0;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=DNA replication regulator SLD2;
GN   Name=SLD2; OrderedLocusNames=CAALFM_CR03340CA;
GN   ORFNames=CaO19.2389, CaO19.9925;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- FUNCTION: Has a role in the initiation of DNA replication. Required at
CC       S-phase checkpoint (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SLD2 family. {ECO:0000305}.
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DR   EMBL; CP017630; AOW31072.1; -; Genomic_DNA.
DR   RefSeq; XP_713222.1; XM_708129.1.
DR   AlphaFoldDB; Q59UH5; -.
DR   SMR; Q59UH5; -.
DR   BioGRID; 1228169; 1.
DR   STRING; 237561.Q59UH5; -.
DR   PRIDE; Q59UH5; -.
DR   GeneID; 3645144; -.
DR   KEGG; cal:CAALFM_CR03340CA; -.
DR   CGD; CAL0000193696; orf19.9925.
DR   VEuPathDB; FungiDB:CR_03340C_A; -.
DR   eggNOG; ENOG502SCF7; Eukaryota.
DR   HOGENOM; CLU_667493_0_0_1; -.
DR   InParanoid; Q59UH5; -.
DR   OrthoDB; 1357089at2759; -.
DR   PRO; PR:Q59UH5; -.
DR   Proteomes; UP000000559; Chromosome R.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0031261; C:DNA replication preinitiation complex; IBA:GO_Central.
DR   GO; GO:0003688; F:DNA replication origin binding; IBA:GO_Central.
DR   GO; GO:0003697; F:single-stranded DNA binding; IBA:GO_Central.
DR   GO; GO:0006270; P:DNA replication initiation; IBA:GO_Central.
DR   GO; GO:0000727; P:double-strand break repair via break-induced replication; IBA:GO_Central.
DR   GO; GO:1902977; P:mitotic DNA replication preinitiation complex assembly; IBA:GO_Central.
DR   InterPro; IPR021110; DNA_rep_checkpnt_protein.
DR   InterPro; IPR040203; Sld2.
DR   PANTHER; PTHR28124; PTHR28124; 1.
DR   Pfam; PF11719; Drc1-Sld2; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cytoplasm; DNA replication; Nucleus; Reference proteome.
FT   CHAIN           1..354
FT                   /note="DNA replication regulator SLD2"
FT                   /id="PRO_0000278431"
FT   REGION          47..133
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          159..184
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          220..277
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        47..74
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        160..184
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        220..251
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   354 AA;  40672 MW;  C33BB20DF8972C44 CRC64;
     MDIVEIKSKI KEWEYAFRKQ HNKLPSKADI KDDVEIHKLY SLYKSIKSGQ QQKPSKQETV
     NEPASVQSSP VKRNDYSPRG ELGPTPQANG RVLSIFDLKM TPPDSSPLKH KSDKASPSAF
     AMPPPQSPVK NIIETPTKSK NKSFVTPIKG RKIVFETPSY LNKHRQNPQT PDSHNNNNNN
     NNNTVINFSV SPSPFKTQRS IGKRLTEVYN TSLKEAEDLK SFNLEEEFQS HEEQESEETE
     TTTNNDRKIA PRSKRTQKRS TRRVKMAPRP VNSKPSLENV NLQDHITKLE EGERKQLVAY
     MDSDEDDENR DGEVGIASVF ESPTKKTRMP VSNNFKRLKI NDPRSRRFKQ RMRR