ID   SLD2_CANGA              Reviewed;         350 AA.
AC   Q6FME9;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=DNA replication regulator SLD2;
GN   Name=SLD2; OrderedLocusNames=CAGL0K08602g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Has a role in the initiation of DNA replication. Required at
CC       S-phase checkpoint (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SLD2 family. {ECO:0000305}.
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DR   EMBL; CR380957; CAG61558.1; -; Genomic_DNA.
DR   RefSeq; XP_448595.1; XM_448595.1.
DR   AlphaFoldDB; Q6FME9; -.
DR   SMR; Q6FME9; -.
DR   STRING; 5478.XP_448595.1; -.
DR   EnsemblFungi; CAG61558; CAG61558; CAGL0K08602g.
DR   GeneID; 2890322; -.
DR   KEGG; cgr:CAGL0K08602g; -.
DR   CGD; CAL0134727; CAGL0K08602g.
DR   VEuPathDB; FungiDB:CAGL0K08602g; -.
DR   eggNOG; ENOG502SCF7; Eukaryota.
DR   HOGENOM; CLU_057728_0_0_1; -.
DR   InParanoid; Q6FME9; -.
DR   OMA; GPTPQIY; -.
DR   Proteomes; UP000002428; Chromosome K.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0031261; C:DNA replication preinitiation complex; IEA:EnsemblFungi.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:EnsemblFungi.
DR   GO; GO:0003697; F:single-stranded DNA binding; IEA:EnsemblFungi.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:EnsemblFungi.
DR   GO; GO:0071163; P:DNA replication preinitiation complex assembly; IEA:EnsemblFungi.
DR   GO; GO:0000727; P:double-strand break repair via break-induced replication; IEA:EnsemblFungi.
DR   GO; GO:0033314; P:mitotic DNA replication checkpoint signaling; IEA:EnsemblFungi.
DR   GO; GO:0031333; P:negative regulation of protein-containing complex assembly; IEA:EnsemblFungi.
DR   InterPro; IPR021110; DNA_rep_checkpnt_protein.
DR   InterPro; IPR040203; Sld2.
DR   PANTHER; PTHR28124; PTHR28124; 2.
DR   Pfam; PF11719; Drc1-Sld2; 2.
PE   3: Inferred from homology;
KW   Cell cycle; Cytoplasm; DNA replication; Nucleus; Reference proteome.
FT   CHAIN           1..350
FT                   /note="DNA replication regulator SLD2"
FT                   /id="PRO_0000278432"
FT   REGION          52..73
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          97..128
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          234..255
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          290..350
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        110..128
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        240..255
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        335..350
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   350 AA;  40992 MW;  2F4248227148DC03 CRC64;
     MDMDVQQVKL KIKRWEHAFI AEHNRPPDKD DIRPLTEMKQ LYKLYSVLKS KERKAEPIQK
     QQTPRKDSNM VLGPTPQIYG KAVSIFEMKV SPLKVEETPT TEVEEDIESE IESSVNRRNS
     DEASANEEKL GIHSVKKRLF ESPKKTENTT HLAVPQVTRY GPNSPLKLAQ TVSIRQHLLT
     PKKKKAEPKS LYTPSPLLKR NSSKTLYELA HEHLQYVEEI KELDQQFKSE IVPIRHGNGQ
     DIGDESDEVP EKKKRRTGVL RRLQFDEDEN DRTIKKDLHK ELLKLKSRKV KEFLGKEDNE
     PSEEEEEEQQ KSEPLPVKKK KPKKYNLVSN NFRRLKLPKK NRNPRFGRRR