ID   SLD2_DEBHA              Reviewed;         459 AA.
AC   Q6BXN9;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 2.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=DNA replication regulator SLD2;
GN   Name=SLD2; OrderedLocusNames=DEHA2B01474g;
OS   Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS   / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX   NCBI_TaxID=284592;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Has a role in the initiation of DNA replication. Required at
CC       S-phase checkpoint (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SLD2 family. {ECO:0000305}.
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DR   EMBL; CR382134; CAG85016.2; -; Genomic_DNA.
DR   RefSeq; XP_457030.2; XM_457030.1.
DR   AlphaFoldDB; Q6BXN9; -.
DR   SMR; Q6BXN9; -.
DR   STRING; 4959.XP_457030.2; -.
DR   EnsemblFungi; CAG85016; CAG85016; DEHA2B01474g.
DR   GeneID; 2913723; -.
DR   KEGG; dha:DEHA2B01474g; -.
DR   VEuPathDB; FungiDB:DEHA2B01474g; -.
DR   eggNOG; ENOG502SCF7; Eukaryota.
DR   HOGENOM; CLU_667493_0_0_1; -.
DR   InParanoid; Q6BXN9; -.
DR   OMA; GPTPQIY; -.
DR   OrthoDB; 1357089at2759; -.
DR   Proteomes; UP000000599; Chromosome B.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR   InterPro; IPR021110; DNA_rep_checkpnt_protein.
DR   InterPro; IPR040203; Sld2.
DR   PANTHER; PTHR28124; PTHR28124; 1.
DR   Pfam; PF11719; Drc1-Sld2; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cytoplasm; DNA replication; Nucleus; Reference proteome.
FT   CHAIN           1..459
FT                   /note="DNA replication regulator SLD2"
FT                   /id="PRO_0000278433"
FT   REGION          79..208
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          327..358
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          407..459
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        93..114
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        134..148
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        149..163
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        164..202
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        407..433
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   459 AA;  53188 MW;  A8AEA2E118E38B5C CRC64;
     MPHQESITQL KQAIKVWEHE FQRSNNRIPS RSDIKVDPKV YELYKTYKVL KAKTNNVRNI
     QDKRTLESAN IGIDINMSES QSDAEDVEEF NNENSDSSNN KLKNQDTELG PTPQANGKVL
     SILDIRLTPP DSSPLKNKVG SRSTDTYSNQ KDEAPEDTFK TPTKTRVNRI NLSELTPTNN
     RGPRNKSLMQ KLEQASSAKN TRIEMHTPER NKVSLLQNME TPQYLAKVNN KFNFDMDDDS
     NDKDNVVAED LHTNSSMKII SSIRSNIIDP ITPTKSPAPL KFQVSPSPLK PHRLFSFGNN
     RKLSDIFNDY KNIKEDPDLI NSIENEEEAA ELDDDDDTIE KDTATNGPKR KRITQKRTTR
     RWKIKPNTEE TKEDKLKNAN IHDEVKKLDD EARKNLVDYM EVNNMHEEDE TTSEEEYVHQ
     DPNHKDMKGK VKPVRMNYQR LKINDPRIKK FKKRMQNRR