SLD2_EMENI
ID SLD2_EMENI Reviewed; 569 AA.
AC Q5B8U0; C8VIT3;
DT 20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2005, sequence version 1.
DT 03-AUG-2022, entry version 71.
DE RecName: Full=DNA replication regulator sld2;
GN Name=sld2; ORFNames=AN3040;
OS Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 /
OS M139) (Aspergillus nidulans).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Nidulantes.
OX NCBI_TaxID=227321;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX PubMed=16372000; DOI=10.1038/nature04341;
RA Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S.,
RA Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V.,
RA Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S.,
RA Braus G.H., Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H.,
RA Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K.,
RA Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R.,
RA Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C.,
RA Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L.,
RA Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
RT "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT fumigatus and A. oryzae.";
RL Nature 438:1105-1115(2005).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
RA Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
RA Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H.,
RA Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M.,
RA Estrada C.G., Geysens S., Goldman G., de Groot P.W., Hansen K.,
RA Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G.,
RA Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L.,
RA Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M.,
RA van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P.,
RA Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J.,
RA Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A.,
RA Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X.,
RA Robson G., Seiboth B., van Solingen P., Specht T., Sun J.,
RA Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H.,
RA van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y.,
RA Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J.,
RA Oliver S.G., Turner G.;
RT "The 2008 update of the Aspergillus nidulans genome annotation: a community
RT effort.";
RL Fungal Genet. Biol. 46:S2-13(2009).
CC -!- FUNCTION: Has a role in the initiation of DNA replication. Required at
CC S-phase checkpoint (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SLD2 family. {ECO:0000305}.
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DR EMBL; AACD01000051; EAA63611.1; -; Genomic_DNA.
DR EMBL; BN001306; CBF83517.1; -; Genomic_DNA.
DR RefSeq; XP_660644.1; XM_655552.1.
DR AlphaFoldDB; Q5B8U0; -.
DR SMR; Q5B8U0; -.
DR STRING; 162425.CADANIAP00010039; -.
DR PRIDE; Q5B8U0; -.
DR EnsemblFungi; CBF83517; CBF83517; ANIA_03040.
DR EnsemblFungi; EAA63611; EAA63611; AN3040.2.
DR GeneID; 2873993; -.
DR KEGG; ani:AN3040.2; -.
DR VEuPathDB; FungiDB:AN3040; -.
DR eggNOG; ENOG502SCF7; Eukaryota.
DR HOGENOM; CLU_033089_0_0_1; -.
DR InParanoid; Q5B8U0; -.
DR OMA; EAHANYR; -.
DR OrthoDB; 1077953at2759; -.
DR Proteomes; UP000000560; Chromosome VI.
DR Proteomes; UP000005890; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0031261; C:DNA replication preinitiation complex; IBA:GO_Central.
DR GO; GO:0003688; F:DNA replication origin binding; IBA:GO_Central.
DR GO; GO:0003697; F:single-stranded DNA binding; IBA:GO_Central.
DR GO; GO:0006270; P:DNA replication initiation; IBA:GO_Central.
DR GO; GO:0000727; P:double-strand break repair via break-induced replication; IBA:GO_Central.
DR GO; GO:1902977; P:mitotic DNA replication preinitiation complex assembly; IBA:GO_Central.
DR InterPro; IPR021110; DNA_rep_checkpnt_protein.
DR InterPro; IPR040203; Sld2.
DR PANTHER; PTHR28124; PTHR28124; 1.
DR Pfam; PF11719; Drc1-Sld2; 1.
PE 3: Inferred from homology;
KW Cell cycle; Cytoplasm; DNA replication; Nucleus; Reference proteome.
FT CHAIN 1..569
FT /note="DNA replication regulator sld2"
FT /id="PRO_0000278434"
FT REGION 52..164
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 193..230
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 289..312
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 350..427
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 461..569
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 52..90
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 91..122
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 138..157
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 352..369
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 391..411
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 478..495
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 512..534
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 569 AA; 62156 MW; B9C5BDB38930F638 CRC64;
MATVTVSEIS NQAAILRAEL KEWERGFAAA NGGKKAERGD IKKVPEIAAK YKEYSRLKSQ
ESASSSKNDK SHSKPTDTQE RSKKRKHSSP NGPEQSQSHC QTTSTPRKSA AGIFQTPSKL
KTTHPADVDP YDSPSVLRRL FSPSTHMQTS SPLKTAIGPT PQRDGKALGL FDLLSESGGS
TATPTAARMA SLKGIAAQTP SKKRKMDTIR EEDEEEEDSP RVERTPASSG KKYMLSALFA
TPTAWKYSSI VDDGTSRGVI GNNDVTKQSP QATRNIDHAN ANLETPSFLR RSTSGLTGPD
PTDMSPLPVR KPQQFVGKGL SQLVQGLRDM EEERLEDEWD VLREIEIEQT GTGVDVPNSQ
AADPNSTGRT FKKKGQKRTT RLVKMRPVVQ AKPTTTRSQP QSLSQSEPRF EHNLVSAGGS
GDVDELGIDD NDLVAVAETQ ADGPPSGRVG IPAAFIDDDL DSLRSISEAE QDSDSDPDYD
ADSKPLGRSK SFSEKMKEAI GATGQGSDTK QAQERQKVKA KEKKEKENID TNAKKPSTRK
INPQAHANYR SLKIRNRGGG RNFGRFRRR
