SLD2_GIBZE
ID SLD2_GIBZE Reviewed; 450 AA.
AC Q4HW93; A0A0E0SLE2; V6RVG7;
DT 20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2005, sequence version 1.
DT 25-MAY-2022, entry version 69.
DE RecName: Full=DNA replication regulator SLD2;
GN Name=SLD2; ORFNames=FGRRES_10765, FGSG_10765;
OS Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084
OS / PH-1) (Wheat head blight fungus) (Fusarium graminearum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium.
OX NCBI_TaxID=229533;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1;
RX PubMed=17823352; DOI=10.1126/science.1143708;
RA Cuomo C.A., Gueldener U., Xu J.-R., Trail F., Turgeon B.G., Di Pietro A.,
RA Walton J.D., Ma L.-J., Baker S.E., Rep M., Adam G., Antoniw J., Baldwin T.,
RA Calvo S.E., Chang Y.-L., DeCaprio D., Gale L.R., Gnerre S., Goswami R.S.,
RA Hammond-Kosack K., Harris L.J., Hilburn K., Kennell J.C., Kroken S.,
RA Magnuson J.K., Mannhaupt G., Mauceli E.W., Mewes H.-W., Mitterbauer R.,
RA Muehlbauer G., Muensterkoetter M., Nelson D., O'Donnell K., Ouellet T.,
RA Qi W., Quesneville H., Roncero M.I.G., Seong K.-Y., Tetko I.V., Urban M.,
RA Waalwijk C., Ward T.J., Yao J., Birren B.W., Kistler H.C.;
RT "The Fusarium graminearum genome reveals a link between localized
RT polymorphism and pathogen specialization.";
RL Science 317:1400-1402(2007).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1;
RX PubMed=20237561; DOI=10.1038/nature08850;
RA Ma L.-J., van der Does H.C., Borkovich K.A., Coleman J.J., Daboussi M.-J.,
RA Di Pietro A., Dufresne M., Freitag M., Grabherr M., Henrissat B.,
RA Houterman P.M., Kang S., Shim W.-B., Woloshuk C., Xie X., Xu J.-R.,
RA Antoniw J., Baker S.E., Bluhm B.H., Breakspear A., Brown D.W.,
RA Butchko R.A.E., Chapman S., Coulson R., Coutinho P.M., Danchin E.G.J.,
RA Diener A., Gale L.R., Gardiner D.M., Goff S., Hammond-Kosack K.E.,
RA Hilburn K., Hua-Van A., Jonkers W., Kazan K., Kodira C.D., Koehrsen M.,
RA Kumar L., Lee Y.-H., Li L., Manners J.M., Miranda-Saavedra D.,
RA Mukherjee M., Park G., Park J., Park S.-Y., Proctor R.H., Regev A.,
RA Ruiz-Roldan M.C., Sain D., Sakthikumar S., Sykes S., Schwartz D.C.,
RA Turgeon B.G., Wapinski I., Yoder O., Young S., Zeng Q., Zhou S.,
RA Galagan J., Cuomo C.A., Kistler H.C., Rep M.;
RT "Comparative genomics reveals mobile pathogenicity chromosomes in
RT Fusarium.";
RL Nature 464:367-373(2010).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1;
RX PubMed=26198851; DOI=10.1186/s12864-015-1756-1;
RA King R., Urban M., Hammond-Kosack M.C.U., Hassani-Pak K.,
RA Hammond-Kosack K.E.;
RT "The completed genome sequence of the pathogenic ascomycete fungus Fusarium
RT graminearum.";
RL BMC Genomics 16:544-544(2015).
CC -!- FUNCTION: Has a role in the initiation of DNA replication. Required at
CC S-phase checkpoint (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SLD2 family. {ECO:0000305}.
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DR EMBL; DS231670; ESU18017.1; -; Genomic_DNA.
DR EMBL; HG970334; CEF87255.1; -; Genomic_DNA.
DR RefSeq; XP_011325639.1; XM_011327337.1.
DR AlphaFoldDB; Q4HW93; -.
DR SMR; Q4HW93; -.
DR STRING; 5518.FGSG_10765P0; -.
DR EnsemblFungi; ESU18017; ESU18017; FGSG_10765.
DR GeneID; 23557649; -.
DR KEGG; fgr:FGSG_10765; -.
DR VEuPathDB; FungiDB:FGRAMPH1_01G20413; -.
DR eggNOG; ENOG502SCF7; Eukaryota.
DR HOGENOM; CLU_033089_0_0_1; -.
DR InParanoid; Q4HW93; -.
DR Proteomes; UP000070720; Chromosome 3.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR InterPro; IPR021110; DNA_rep_checkpnt_protein.
DR InterPro; IPR040203; Sld2.
DR PANTHER; PTHR28124; PTHR28124; 2.
DR Pfam; PF11719; Drc1-Sld2; 1.
PE 3: Inferred from homology;
KW Cell cycle; Cytoplasm; DNA replication; Nucleus; Reference proteome.
FT CHAIN 1..450
FT /note="DNA replication regulator SLD2"
FT /id="PRO_0000278435"
FT REGION 59..137
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 150..223
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 288..413
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 428..450
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 79..94
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 117..134
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 150..164
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 174..210
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 303..317
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 394..413
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 450 AA; 49990 MW; 4529D02F22D8E5F2 CRC64;
MDEDTRAEYE STSQQLRIDL KTWETDWAKS HEGKKPGRGD IKANEDIAAK YKQYNKVRDI
LSGKISPPSK HAPKSTKRKS DGLSAQTPIK QNKHIETPAK NRTQNHDEDL MNTPAISRKL
FSPTSVTSVG PTPQRDGQVL GLFDLLVEKE LGTPSKKDSA TKTGSARKVD ATPSKRSAAT
DDDEDERLGR TPMSSSKRQR LDHFLTPLKN KDGNKDAATP SSVSKLQFDT PAFLKRNTLP
VLEENGDFDA PAPLRLPRKP FARGLSEIVA SLRKVEEESL DDDLDALRDI EDGGMGEPKP
KTLFPSKPKD DILVDDNEAR QLPLGGFDDE GVYDSPVEGD NPTRVYKKKG QKRTTRMAKM
RPVRVNRPEN MAANPQSDVE NDEIQAGGED AGSDFDDIVE KKPAQKKEGT VKKAARKVNE
LAHANFQRLK LRNHGAKGGP GINSRFRRRK
