ID   SLD2_KLULA              Reviewed;         379 AA.
AC   Q6CK38;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   20-FEB-2007, sequence version 2.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=DNA replication regulator SLD2;
GN   Name=SLD2; OrderedLocusNames=KLLA0F13794g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Has a role in the initiation of DNA replication. Required at
CC       S-phase checkpoint (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SLD2 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAG98409.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CR382126; CAG98409.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; XP_455701.1; XM_455701.1.
DR   AlphaFoldDB; Q6CK38; -.
DR   SMR; Q6CK38; -.
DR   STRING; 28985.XP_455701.1; -.
DR   EnsemblFungi; CAG98409; CAG98409; KLLA0_F13794g.
DR   GeneID; 2895818; -.
DR   KEGG; kla:KLLA0_F13794g; -.
DR   eggNOG; ENOG502SCF7; Eukaryota.
DR   HOGENOM; CLU_057728_0_0_1; -.
DR   InParanoid; Q6CK38; -.
DR   Proteomes; UP000000598; Chromosome F.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0031261; C:DNA replication preinitiation complex; IEA:EnsemblFungi.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:EnsemblFungi.
DR   GO; GO:0003697; F:single-stranded DNA binding; IEA:EnsemblFungi.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:EnsemblFungi.
DR   GO; GO:0071163; P:DNA replication preinitiation complex assembly; IEA:EnsemblFungi.
DR   GO; GO:0000727; P:double-strand break repair via break-induced replication; IEA:EnsemblFungi.
DR   GO; GO:0033314; P:mitotic DNA replication checkpoint signaling; IEA:EnsemblFungi.
DR   GO; GO:0031333; P:negative regulation of protein-containing complex assembly; IEA:EnsemblFungi.
DR   InterPro; IPR021110; DNA_rep_checkpnt_protein.
DR   InterPro; IPR040203; Sld2.
DR   PANTHER; PTHR28124; PTHR28124; 2.
DR   Pfam; PF11719; Drc1-Sld2; 2.
PE   3: Inferred from homology;
KW   Cell cycle; Cytoplasm; DNA replication; Nucleus; Reference proteome.
FT   CHAIN           1..379
FT                   /note="DNA replication regulator SLD2"
FT                   /id="PRO_0000278436"
FT   REGION          287..306
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          324..379
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        324..342
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   379 AA;  43088 MW;  8AB7247975022F82 CRC64;
     MNGIKETDTV NAPLLLVISS ASMDALKIEI KLWERAFEKE HGRLPEKDDI KKDKEVKRKY
     KQYAQLKKDA TVKPSVEVNV EQTPVKSHVN NTKAEFGPTP QMNGKLVSIF EMQVSAMKTH
     QSDQEDIVGS PVRSNDLVRR QLNFSITPNS SPMKQVPNLS ANIVVSRPKY GPNSPMRIGD
     IGLQLSETPK TLGRTLDLKS SPFSPSPLIK RPVKTLSQLA KEHAIIKDEF ESNPEDFSEF
     TAIRTLMEKL MQEEHMDIIE EGDEGTVGNE TESNYVRKVK TIKKRTKAKM RPAALNEKST
     NIPDKNVHEQ LAKLKEREYN KMLGKEVEES ESDSEQQSNP PVKKKQRKSK YNLVSNNFKR
     LNLPTKAGRN RASKWRGRR